Investigating the hair-bundle state space in an exploration of inner ear tuning

在内耳调谐探索中研究发束状态空间

• 批准号: 8591535
• 负责人: Joshua D Salvi
• 金额: $ 4.72万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8591535
• 关键词: Affect; American; Auditory; Behavior; Calibration; Characteristics; Data; Elasticity; Environment; Esthesia; Etiology; Feedback; Foundations; Frequencies; Functional disorder; Future; Glean; Hair; Hair Cells; Hearing; Human; Intervention; Investigation; Knowledge; Labyrinth; Lead; Locales; Location; Maps; Mechanics; Modeling; Noise; Pharmaceutical Preparations; Prevalence; Process; Property; Protocols documentation; Public Health; Relative (related person); Sensory Receptors; Stimulus; System; Time; arm; hearing impairment; improved; macula; operation; public health relevance; research study; tool; two-dimensional; young adult

DESCRIPTION (provided by applicant): Noise-induced, drug-induced, and congenital hearing loss results from damage to hair cells, the sensory receptors of the inner ear. With half of Americans over 75 afflicted by moderate to severe hearing impairment and a worldwide rise in the prevalence of hearing impairment in younger adults, hearing loss is a significant public-health concern. Knowledge of the normal operation of the hair cell-including that of its mechanical antenna, the hair bundle-will contribute to understanding the pathophysiology of hearing loss and developing treatments for it. The proposed study seeks to examine the dynamical properties of a hair bundle that underlie its ability to amplify mechanical stimuli. As a dynamical system, the activity of a hair bundle can be characterized by a state space that describes the bundle's behavior under various conditions. Included in the state space is a Hopf bifurcation, an instability that endows the hair bundle with the ability to self-tune near criticalty. This dynamical system can be readily explored by manipulation of two control parameters, offset force and stiffness. I will attempt to coerce the hair bundle to cross its critical point, demonstrating for the first time the presence of a Hopf bifurcation embedded in hair-bundle mechanics. This demonstration will provide a tool for further investigation of phenomena characteristic of the active process in hearing. Thus, by controlling mechanical properties, I shal elucidate the functions of hair bundles that endow humans with highly resolved auditory sensation.

描述（由申请人提供）：噪声性听力损失、药物性听力损失和先天性听力损失是由于内耳感觉感受器毛细胞受损所致。由于75岁以上的美国人中有一半患有中度至重度听力障碍，以及全球年轻人听力障碍患病率的上升，听力损失是一个重大的公共卫生问题。毛细胞的正常运作的知识，包括其机械天线，毛束，将有助于理解听力损失的病理生理学和开发治疗it.The拟议中的研究旨在研究毛束的动力学特性，其基础是它的能力，以放大机械刺激。作为 在动力系统中，发束的活动可以由描述发束在各种条件下的行为的状态空间来表征。包括在状态空间是一个霍普夫分岔，不稳定，赋予头发束的能力，自我调整近临界。这个动力系统可以很容易地探索两个控制参数，偏移力和刚度的操纵。我将试图迫使头发束越过其临界点，证明了第一次存在的霍普夫分叉嵌入头发束力学。这个演示将提供一个工具，进一步调查的现象特征的积极过程中的听力。因此，通过控制机械性能，我将阐明赋予人类高分辨听觉的毛束的功能。