4D Statistical Atlas from Multimodal Tongue MR Images

多模态舌 MR 图像的 4D 统计图谱

基本信息

  • 批准号:
    8510213
  • 负责人:
  • 金额:
    $ 9.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-03-01 至 2015-02-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The tongue is the gateway to the body and is critical in eating, speaking, and breathing. Its function is compromised by disease and also by treatment, such as surgery or radiation for tongue cancer. A key to understanding the relationship between the structure and function of the tongue is to analyze motion changes in localized tongue regions and map them to anatomy. The use of three types of magnetic resonance (MR) images (i.e., high-resolution, cine, and tag) offers new and enhanced capabilities for exploring normal and diseased tongue behavior, advancing our knowledge on a wide variety of speech-related disorders. Quantitative measures derived from MR images, such as tissue compression, expansion, principle strain, and muscle mechanics play a crucial role to characterize normal and abnormal motion of the tongue. However, the critical hurdle currently faced in this field is a lack of tools for accurate, reproducible, and fully automated quantitative characterization of 4D (3D space with time) tongue motion in a normalized space in order to compare and contrast subjects despite their variable tongue sizes, shapes, and motion patterns. A powerful way to measure changes and compromises in tongue structure and function is via a 4D statistical atlas and associated image analysis techniques. Atlases integrate diverse imaging information for individuals and groups, by correlating images with quantitative measurements, and constructing diagnostic tools. The proposed study examines structural and functional changes in the tongues of post- glossectomy patients. In future, this atlas can be applied to any normal or disordered population. The K99 Mentored Phase allows me to transition to a career that studies tongue anatomy, speech science, and vocal tract-related disorders. In addition, I will execute Aim 1: to develop an MRI registration framework and an interactive visualization tool for tongue image analysis using multiple MRI methods. In the R00 Independent Phase, I will pursue Aim 2: to establish a 4D statistical atlas of the tongue that represents the relationship between tongue motion, mechanics, and speech, and Aim 3: to assess the effects of tongue cancer surgery on tongue tip, blade, and body interaction. A mentoring committee has been assembled to guide the research in the K99 phase and facilitate my training. Dr. Stone, who is an expert in speech science and imaging, will provide primary mentorship and guidance in the overall study design. Co- mentor, Dr. Prince, is a world expert in MR image analysis. He will guide me in image analysis. The opportunities provided by this award will not only allow me to pursue potentially ground-breaking research, but will also provide me with valuable mentorship and training for my career as an independent investigator.
描述(由申请人提供):舌头是通往身体的门户,在进食,说话和呼吸中至关重要。它的功能会受到疾病和治疗的影响,例如舌癌的手术或放射治疗。了解舌的结构和功能之间的关系的关键是分析局部舌区域的运动变化并将其映射到解剖学上。使用三种类型的磁共振(MR)图像(即,高分辨率、电影和标签)提供了新的和增强的能力,用于探索正常和患病的舌头行为,推进了我们对各种各样的语言相关障碍的认识。来自MR图像的定量测量,例如组织压缩、膨胀、主应变和肌肉力学,对于表征舌的正常和异常运动起着至关重要的作用。然而,该领域目前面临的关键障碍是缺乏准确、可重复和全自动定量的工具。 在一个实施例中,本发明提供了在归一化空间中表征4D(3D空间与时间)舌头运动的方法,以便比较和对比受试者,尽管他们的舌头大小、形状和运动模式可变。测量舌头结构和功能的变化和妥协的一种有效方法是通过4D统计图谱和相关的图像分析技术。通过将图像与定量测量相关联,并构建诊断工具,影像学整合了个人和群体的各种成像信息。这项研究旨在探讨舌切除术后患者舌的结构和功能变化。在未来,这个地图集可以应用于任何正常或紊乱的人群。K99指导阶段允许我过渡到研究舌头解剖学,言语科学和声道相关疾病的职业生涯。此外,我将 执行目标1:开发MRI配准框架和交互式可视化工具,用于使用多种MRI方法进行舌图像分析。在R00独立阶段,我将追求目标2:建立舌头的4D统计图谱,代表舌头运动,力学和语言之间的关系,目标3:评估舌癌手术对舌尖,刀片和身体相互作用的影响。一个指导委员会已经成立,以指导K99阶段的研究,并促进我的培训。斯通博士是言语科学和成像方面的专家,他将在整个研究设计中提供主要的指导和指导。共同导师,博士王子,是一个世界级的专家在磁共振图像分析。他将指导我进行图像分析。该奖项提供的机会不仅使我能够从事潜在的开创性研究,而且还将为我作为独立调查员的职业生涯提供宝贵的指导和培训。

项目成果

期刊论文数量(0)
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Jonghye Woo其他文献

Jonghye Woo的其他文献

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{{ truncateString('Jonghye Woo', 18)}}的其他基金

A holistic approach to identifying functional units of tongue motion during speech
识别言语过程中舌头运动功能单位的整体方法
  • 批准号:
    10376818
  • 财政年份:
    2020
  • 资助金额:
    $ 9.72万
  • 项目类别:
A holistic approach to identifying functional units of tongue motion during speech
识别言语过程中舌头运动功能单位的整体方法
  • 批准号:
    10604272
  • 财政年份:
    2020
  • 资助金额:
    $ 9.72万
  • 项目类别:
4D Statistical Atlas from Multimodal Tongue MR Images
多模态舌 MR 图像的 4D 统计图谱
  • 批准号:
    9187001
  • 财政年份:
    2013
  • 资助金额:
    $ 9.72万
  • 项目类别:
4D Statistical Atlas from Multimodal Tongue MR Images
多模态舌 MR 图像的 4D 统计图谱
  • 批准号:
    8617263
  • 财政年份:
    2013
  • 资助金额:
    $ 9.72万
  • 项目类别:

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