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4D Statistical Atlas from Multimodal Tongue MR Images

多模态舌 MR 图像的 4D 统计图谱

基本信息

批准号：
9187001
负责人：
Jonghye Woo
金额：
$ 24.87万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-03-01 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9187001
关键词：
Affect Anatomy Apical Atlases Award Behavior Breathing Cine Magnetic Resonance Imaging Classification Computer software Data Data Set Deglutition Development Diagnosis Diagnostic Disease Eating Foundations Future Geese Generations Glossectomy Goals Health Human Image Image Analysis Individual Jaw Journals Knowledge Lateral Location Magnetic Resonance Imaging Maps Mastication Measurement Measures Mechanics Medical Research Mentors Mentorship Modality Motion Muscle Operative Surgical Procedures Patients Pattern Phase Play Population Positioning Attribute Procedures Process Production Publishing Quality of life Radiation Reproducibility Research Research Design Research Personnel Resolution Role Science Shapes Source Code Speech Speech Disorders Speech Intelligibility Speech Pathology Structure Surface Surgeon System Target Populations Techniques Testing Time Tissues Tongue Tongue Diseases Torsion Training Variant Visualization software Work base bioimaging cancer surgery career computerized tools forest image processing image registration imaging modality improved insight malignant tongue neoplasm motor control movie multimodality outcome forecast preference public health relevance spatiotemporal theories tongue apex tool

项目摘要

DESCRIPTION (provided by applicant): The tongue is the gateway to the body and is critical in eating, speaking, and breathing. Its function is compromised by disease and also by treatment, such as surgery or radiation for tongue cancer. A key to understanding the relationship between the structure and function of the tongue is to analyze motion changes in localized tongue regions and map them to anatomy. The use of three types of magnetic resonance (MR) images (i.e., high-resolution, cine, and tag) offers new and enhanced capabilities for exploring normal and diseased tongue behavior, advancing our knowledge on a wide variety of speech-related disorders. Quantitative measures derived from MR images, such as tissue compression, expansion, principle strain, and muscle mechanics play a crucial role to characterize normal and abnormal motion of the tongue. However, the critical hurdle currently faced in this field is a lack of tools for accurate, reproducible, and fully automated quantitative characterization of 4D (3D space with time) tongue motion in a normalized space in order to compare and contrast subjects despite their variable tongue sizes, shapes, and motion patterns. A powerful way to measure changes and compromises in tongue structure and function is via a 4D statistical atlas and associated image analysis techniques. Atlases integrate diverse imaging information for individuals and groups, by correlating images with quantitative measurements, and constructing diagnostic tools. The proposed study examines structural and functional changes in the tongues of post- glossectomy patients. In future, this atlas can be applied to any normal or disordered population. The K99 Mentored Phase allows me to transition to a career that studies tongue anatomy, speech science, and vocal tract-related disorders. In addition, I will execute Aim 1: to develop an MRI registration framework and an interactive visualization tool for tongue image analysis using multiple MRI methods. In the R00 Independent Phase, I will pursue Aim 2: to establish a 4D statistical atlas of the tongue that represents the relationship between tongue motion, mechanics, and speech, and Aim 3: to assess the effects of tongue cancer surgery on tongue tip, blade, and body interaction. A mentoring committee has been assembled to guide the research in the K99 phase and facilitate my training. Dr. Stone, who is an expert in speech science and imaging, will provide primary mentorship and guidance in the overall study design. Co- mentor, Dr. Prince, is a world expert in MR image analysis. He will guide me in image analysis. The opportunities provided by this award will not only allow me to pursue potentially ground-breaking research, but will also provide me with valuable mentorship and training for my career as an independent investigator.

描述(申请人提供)：舌头是通向身体的大门，在进食、说话和呼吸中起着至关重要的作用。它的功能受到疾病和治疗的影响，比如舌癌的手术或放射治疗。要了解舌的结构和功能之间的关系，关键是分析舌局部区域的运动变化，并将其映射到解剖学上。三种类型的磁共振(MR)图像(即高分辨率、电影和TAG)的使用为探索正常和疾病的舌部行为提供了新的和增强的能力，促进了我们对各种与言语相关的疾病的了解。从MR图像中提取的定量测量，如组织压缩、扩张、主应变和肌肉力学，在表征舌体的正常和异常运动方面起着至关重要的作用。然而，这一领域目前面临的关键障碍是缺乏准确、可重复和完全自动化的定量工具在归一化空间中描述4D(3D空间和时间)舌头运动，以便比较和对比受试者，尽管他们的舌头大小、形状和运动模式各不相同。通过4D统计图谱和相关的图像分析技术，是测量舌结构和功能变化和妥协的一种强有力的方法。地图集通过将图像与定量测量相关联，并构建诊断工具，为个人和群体整合了不同的成像信息。这项拟议的研究考察了舌切除术后患者舌头的结构和功能变化。将来，这份地图集可以适用于任何正常或无序的人群。K99指导阶段让我可以过渡到研究舌头解剖学、语音科学和声道相关疾病的职业。另外，我会执行目标1：开发用于多种MRI方法的舌象分析的MRI配准框架和交互式可视化工具。在R00独立阶段，我将追求目标2：建立代表舌头运动、力学和语音之间关系的舌头4D统计图谱，以及目标3：评估舌癌手术对舌尖、舌叶和身体互动的影响。已经成立了一个指导委员会来指导K99阶段的研究并促进我的培训。斯通博士是语音科学和成像方面的专家，他将在整个研究设计中提供主要的指导和指导。共同导师普林斯博士是磁共振图像分析方面的世界专家。他将指导我进行图像分析。这一奖项提供的机会不仅使我能够从事可能具有开创性的研究，还将为我作为一名独立调查员的职业生涯提供宝贵的指导和培训。