Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention

描述（由申请人提供）：在25年的癌症预防研究中，很少有干预措施对一种以上的癌症有影响。慢性炎症有助于多个器官的致癌作用，因此抗炎剂有可能降低几个部位的癌症风险。1999年，艾米丽白色博士获得了VITALTM和生活方式（VITAL）研究的资助，这是一项关于膳食补充剂使用和癌症风险的前瞻性队列研究。来自西部华盛顿州的77,738名年龄在50-76岁之间的男性和女性通过完成一份关于过去10年中使用38种补充剂、饮食和生活方式因素的详细问卷而进入该队列。超过54，000名参与者还提供了口腔细胞样本进行DNA检测。迄今为止，最强有力和最一致的发现是，只有抗炎补充剂（特别是葡萄糖胺，软骨素和鱼油/n-3脂肪酸）似乎可以降低几种癌症的风险。 白色博士的这一拟议的既定研究者奖（K 05）将为抗炎暴露和癌症风险领域的指导和研究以及她的学员感兴趣的其他主题提供保护时间。申请人有指导和指导培训计划的广泛历史，目前正在指导来自一系列领域的1名博士前，4名博士后和7名初级教师，并承诺在未来继续指导。来自大型VITAL队列的数据和样本的可用性，随着研究的成熟，癌症数量的增加（预计到2011年将有超过10，300种癌症），以及可以研究的癌症范围（前列腺、乳腺、肺、结直肠、黑色素瘤、膀胱、血液/淋巴）吸引年轻的研究人员与她合作。除了提供想法，除了提供指导和研究平台，为学员发表研究论文外，申请人还努力为学员开展独立研究提供指导。 该奖项将为白色博士提供额外的时间，以扩大她和她的学员的研究，以其他抗炎补充剂（例如，葡萄糖，MSM），抗炎药物，以及促炎和抗炎饮食因子（例如，n-6和n-3多不饱和脂肪酸）与多种癌症发病率、癌症总发病率和癌症死亡率的关系。此外，该奖项将提供试点数据，使她和她的学员分支到短期随机试验的影响，潜在的化学预防剂对生物标志物的炎症，并研究抗炎暴露的利益和生存从癌症。白色博士也是《流行病学中的暴露测量原理》一书的作者，这一奖项将为她提供专门的时间，在这一领域进行额外的方法学研究。为了实现这一目标，申请人将减少她的大量行政责任，包括辞去她作为华盛顿大学公共卫生学院研究副院长的职务。

DESCRIPTION (provided by applicant): In the 25 years of cancer prevention research, few interventions have been identified that have effects on more than one type of cancer. Chronic inflammation contributes to carcinogenesis in multiple organs, thus anti-inflammatory agents have the potential to reduce the risk of cancer at several sites. In 1999, Dr. Emily White was awarded funding for the VITamins And Lifestyle (VITAL) study, a prospective cohort study of dietary supplement use and cancer risk. 77,738 men and women in western Washington State, age 50-76, entered the cohort, by completing a detailed questionnaire on use of 38 supplements over the past 10 years, diet, and lifestyle factors. Over 54,000 participants also provided buccal cell specimens for DNA. The strongest and most consistent findings to date are that only the anti-inflammatory supplements (in particular glucosamine, chondroitin and fish oil/n-3 fatty acids) appear to reduce the risk of several cancers. This proposed Established Investigator Award (K05) for Dr. White would provide protected time for mentoring and research in the area of anti-inflammatory exposures and cancer risk, and other topics of interest to her trainees. The applicant has an extensive history of mentoring and directing training programs, is currently mentoring 1 pre-doctoral, 4 post-doctoral and 7 junior faculty members from a range of fields, and has a strong commitment to continue mentoring in the future. The availability of the data and specimens from the large VITAL cohort, the increasing numbers of cancers as the study matures (over 10,300 cancers expected by 2011), and the range of cancers that can be studied (prostate, breast, lung, colorectal, melanoma, bladder, blood/lymph) attract young investigators to work with her. In addition to providing ideas, guidance and the research platform for publishing research papers to her trainees, the applicant endeavors to provide guidance in developing their independent research as well. This award would provide additional time for Dr. White to expand her and her trainees' research to other anti-inflammatory supplements (e.g., grapeseed, MSM) which have not been ascertained by other cohorts, to anti-inflammatory drugs, and to pro- and anti-inflammatory dietary factors (e.g., n-6 and n-3 polyunsaturated fatty acids) in relation to incidence of multiple types of cancer, total cancer incidence and cancer mortality. In addition, the award would provide pilot data to allow her and her trainees to branch out into short-term randomized trials of the effects of potential chemopreventive agents on biomarkers of inflammation, and to studies of the anti-inflammatory exposures of interest and survival from cancer. Dr. White is also author of the book "Principles of Exposure Measurement in Epidemiology", and this award would provide dedicated time for her to pursue additional methodologic research in this area. To accomplish this, the applicant will reduce her large administrative responsibilities, including stepping down from her role as Associate Dean for Research in the University of Washington School of Public Health.