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Quorum Sensing Regulation of EHEC Virulence Genes

Quorum Sensing Regulation of EHEC Virulence Genes
肠出血性大肠杆菌毒力基因的群体感应调控
批准号：
10384063
负责人：
VANESSA SPERANDIO
金额：
$62.7万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
未结题
起止时间：
2023-01-01 至 2027-12-31
来源：
https://reporter.nih.gov/project-details/10384063
关键词：
2 year old2-arachidonylglycerolAdrenergic AgentsAnimalsAntibioticsApplications GrantsAttenuatedBeta-glucuronidaseBiochemicalCannabidiolCannabinoidsCarbonChildCitrobacter rodentiumColitisDiseaseDown-RegulationEndocannabinoidsEnterocytesEnzymesEpinephrineEpithelial CellsEquilibriumEscherichia coliEscherichia coli EHECFDA approvedGene ExpressionGene Expression RegulationGenesGeneticGlucuronatesGoalsGrantHormonesIn VitroInfectionInstructionIntestinesIsomeraseKnock-outKnowledgeLarge IntestineLesionLiposomesMapsMediatingMembraneMusNeurotransmittersNorepinephrineOxidopaminePathogenesisPathogenicity IslandPathway interactionsPlantsPrincipal InvestigatorProcessProductionProgress ReportsQuantitative Reverse Transcriptase PCRRegulationRegulonResearchRoleSignal TransductionSourceStressSugar AcidsSystemTranslatingUnited States National Institutes of HealthVirulenceWestern Blottingendogenous cannabinoid systemexperimental studymicrobiotamouse modelmutantnovel therapeutic interventionpathogenpharmacologicpreventprogramsprotein expressionprotein-histidine kinasequorum sensingreceptorreconstitutionresponsetranscriptomicsuronatevirulence gene

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英文摘要
See continuation page 24 for project summary. Per NIH instructions, submit a one-page abstract of the research plan for the entire extension period (3-5 years) RELEVANCE (See instructions): The goal of this project is to investigate how different host neurotransmitters impact the balance among microbiota-pathogen-host interactions. We will assess how the stress hormones epinephrine and norepinephrine have their impact on enterohemorrhagic E. coli (EHEC) virulence gene regulation counteracted by an endocannabi noi d. We will also investigate how the microbiota alters the availability of the active form of these neurotransmitters in the gut.
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  • 项目类别：
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
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  • 负责人：
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  • 依托单位：
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  • 批准号：
    10333398
  • 项目类别：
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  • 批准号：
    10219567
  • 项目类别：
  • 资助金额：
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  • 财政年份：
    2021
  • 负责人：
    VANESSA SPERANDIO
  • 依托单位：
    UT SOUTHWESTERN MEDICAL CENTER
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