Admin Core

管理核心

• 批准号: 10404413
• 负责人: Marc Nathan Wein
• 金额: $ 22.61万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404413
• 关键词: Acceleration; Advisory Committees; Anabolic Agents; Award; Bioinformatics; Biology; Bone Formation Stimulation; Capsicum; Center for Translational Science Activities; Clinical; Communication; Communities; Data; Development; Genomics; Goals; Grant; Human; Human Resources; Infrastructure; Institution; International; Journals; Leadership; London; Mission; Molecular Mechanisms of Action; Mus; Osteoblasts; Osteocytes; Osteoporosis; Patient Recruitments; Reporting; Research; Research Personnel; Resources; Role; Scientist; Series; Structure; Teleconferences; Time; Trans-Omics for Precision Medicine; Translational Research; Travel; Visit; Work; bone; catalyst; college; improved; inter-institutional; knowledge translation; medical schools; meetings; multidisciplinary; novel therapeutic intervention; professor; progenitor; programs; response; skeletal; success; symposium; transcriptomics; translational research program

Project Summary – Administrative Core The goal of the CORT is to elucidate mechanisms of action of osteoporosis anabolic therapies, and to understand why they stop working over time. In doing so, the CORT will accelerate translation knowledge to improve our understanding of osteoporosis pathobiology. To achieve this goal, the overall focus of the CORT is to define the cellular and molecular mechanisms of action of currently-used osteoporosis anabolic agents in humans. A highly-collaborative, multi- disciplinary, international network of investigators based at several Harvard Medical School- based institutions and Imperial College London have come together to tackle this challenge. The goal of the Administrative Core is to provide administrative support for all aspects of the CORT and its scientific mission. To achieve this goal, three specific aims are proposed. First, the Administrative Core will support the scientific goals of the CORT via coordinating management across projects, supporting a pilot award program, supporting patient recruitment efforts, and facilitating scientific and regulatory reporting. Second, the Administrative Core will provide infrastructure and timely support to ‘unburden’ CORT investigators by coordinating teleconferencing, meeting planning, travel arrangements, and performing post-award grants management. Third, the Administrative Core will function as a ‘hub’ for engagement and dissemination of CORT scientific activities with the broader academic skeletal biology and osteoporosis research communities. These efforts will rely on integration with existing dissemination networks for translational science, a Visiting Professor series, and developing a robust series of platforms to publicize the CORT mission. The Administrative Core leadership structure will involve a director and associate director with appropriate expertise in fundamental, translational, and clinical skeletal biology research, with support from an appropriately-selected External Advisory Committee panel. In sum, the Administrative Core represent an integral component needed for the success of this collaborative, multi-disciplinary, inter-institutional translational research program.

项目摘要-行政核心 CORT的目的是阐明骨质疏松症合成代谢疗法的作用机制， 并理解为什么它们会随着时间的推移而停止工作。在这样做的过程中，CORT将加速 翻译知识，以提高我们对骨质疏松症病理生物学的理解。实现 为了实现这一目标，CORT的总体重点是确定细胞和分子机制， 目前使用的骨质疏松症合成代谢剂在人类中的作用。一个高度合作的，多- 学科，国际网络的研究人员设在几个哈佛医学院- 伦敦大学和伦敦帝国理工学院联合起来应对这一挑战。 行政核心的目标是为联合国系统的所有方面提供行政支助， CORT及其科学使命。为实现这一目标，提出了三个具体目标。第一、 行政核心将通过协调，支持CORT的科学目标 跨项目管理，支持试点奖励计划，支持患者招募 努力，并促进科学和监管报告。第二，行政核心将 提供基础设施和及时的支持，通过协调， 电话会议、会议规划、差旅安排和执行授标后赠款 管理第三，行政核心将作为参与的“枢纽”， 通过更广泛的学术骨骼生物学传播CORT科学活动， 骨质疏松症研究社区。这些努力将依赖于与现有的 传播网络的翻译科学，访问教授系列，并制定了一个 强大的一系列平台来宣传CORT使命。行政核心领导 结构将包括一名董事和一名副董事， 翻译和临床骨骼生物学研究，并得到适当选择的 外部咨询委员会小组。总而言之，行政核心是一个整体， 这一合作，多学科，机构间的成功所需的组成部分， 翻译研究计划。