Admin Core

项目摘要-管理核心 CORT的目标是阐明骨质疏松症合成代谢疗法的作用机制， 并理解他们为什么会随着时间的推移而停止工作。在此过程中，CORT将加速 翻译知识，提高我们对骨质疏松症病理生物学的认识。要实现 这一目标，CORT的总体焦点是定义细胞和分子机制 目前使用的骨质疏松症合成代谢药对人体的作用。高度协作、多 纪律，国际调查网络，总部设在几个哈佛医学院- 总部设在伦敦的机构和伦敦帝国理工学院携手应对了这一挑战。 行政核心的目标是为以下各方面提供行政支助 CORT及其科学任务。为了实现这一目标，提出了三个具体目标。第一, 行政核心将通过协调支持CORT的科学目标 跨项目管理，支持试点奖励计划，支持患者招募 努力，并促进科学和监管报告。第二，行政核心意志 通过协调为CORT调查人员提供基础设施和及时支持 电话会议、会议规划、旅行安排和执行获奖后赠款 管理层。第三，行政核心将作为接触和 通过更广泛的学术骨骼生物学传播CORT科学活动和 骨质疏松症研究社区。这些努力将依赖于与现有的 翻译科学传播网络，客座教授系列，并开发 宣传CORT任务的一系列强有力的平台。行政核心领导 结构将包括一名董事和副董事，他们在基础、 翻译和临床骨骼生物学研究，由适当选择的 外部咨询委员会小组。总而言之，行政核心是一个完整的 此协作、多学科、跨机构的成功所需的组件 翻译研究计划。

Project Summary – Administrative Core The goal of the CORT is to elucidate mechanisms of action of osteoporosis anabolic therapies, and to understand why they stop working over time. In doing so, the CORT will accelerate translation knowledge to improve our understanding of osteoporosis pathobiology. To achieve this goal, the overall focus of the CORT is to define the cellular and molecular mechanisms of action of currently-used osteoporosis anabolic agents in humans. A highly-collaborative, multi- disciplinary, international network of investigators based at several Harvard Medical School- based institutions and Imperial College London have come together to tackle this challenge. The goal of the Administrative Core is to provide administrative support for all aspects of the CORT and its scientific mission. To achieve this goal, three specific aims are proposed. First, the Administrative Core will support the scientific goals of the CORT via coordinating management across projects, supporting a pilot award program, supporting patient recruitment efforts, and facilitating scientific and regulatory reporting. Second, the Administrative Core will provide infrastructure and timely support to ‘unburden’ CORT investigators by coordinating teleconferencing, meeting planning, travel arrangements, and performing post-award grants management. Third, the Administrative Core will function as a ‘hub’ for engagement and dissemination of CORT scientific activities with the broader academic skeletal biology and osteoporosis research communities. These efforts will rely on integration with existing dissemination networks for translational science, a Visiting Professor series, and developing a robust series of platforms to publicize the CORT mission. The Administrative Core leadership structure will involve a director and associate director with appropriate expertise in fundamental, translational, and clinical skeletal biology research, with support from an appropriately-selected External Advisory Committee panel. In sum, the Administrative Core represent an integral component needed for the success of this collaborative, multi-disciplinary, inter-institutional translational research program.