Multi-component HIV Intervention Packages for Chinese MSM

针对中国男男性行为者的多组分艾滋病毒干预方案

• 批准号: 8241895
• 负责人: STEN H. VERMUND
• 金额: $ 85.15万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8241895
• 关键词: AIDS prevention; Accounting; Acquired Immunodeficiency Syndrome; Adherence; Adopted; Alcohol consumption; Anti-Retroviral Agents; Area; Asians; Awareness; Behavior Therapy; Behavioral; Bundling; Caring; China; Chinese American; Chinese People; Cities; Clinical Trials; Clinical Trials Design; Communities; Counseling; Data; Development; Early identification; Environment; Epidemic; Event; Future; Goals; Grant; HIV; HIV Infections; HIV Seropositivity; HIV vaccine; Health Promotion; Human immunodeficiency virus test; Incidence; Infection; Intervention; Knowledge; Link; Literature; Male Circumcision; Measures; Meta-Analysis; Methods; Modeling; Persons; Pilot Projects; Population; Preparation; Prevention; Prevention approach; Preventive Intervention; Protocols documentation; Provider; Public Health; Publishing; Randomized Clinical Trials; Randomized Controlled Clinical Trials; Research Personnel; Research Priority; Review Literature; Risk; Risk Reduction; Services; Site; Testing; Thailand; Viral Load result; Virus; Western Europe; Work; alcohol abuse therapy; alcohol risk reduction; antiretroviral therapy; base; behavior change; community consultation; design; disorder prevention; effective intervention; efficacy testing; experience; high risk; improved; innovation; man; mathematical model; member; men; men who have sex with men; peer; prevent; programs; public health relevance; rectal microbicide; service intervention; sex; systematic review; theories; transmission process; trend

DESCRIPTION (provided by applicant): There is no proven effective prevention intervention specifically for men who have sex with men (MSM) population. Bundling partial measures and optimize combinations of interventions may have a substantial impact on HIV seroincidence. The goal of this study is to develop and pilot test a package of Test and Link-to-Care (TLC)-based interventions for preparation of future community-level randomized clinical trial. The specific aims are: (1) To conduct a systematic review of the literature and mathematical modeling to guide the selection of HIV prevention interventions for MSM in China; (2) To conduct a pilot study to evaluate the feasibility, acceptability and initial efficacy of a multi-component TLC intervention packages among MSM in China; and (3) To refine and finalize menu-driven HIV prevention packages and design a multi-site randomized clinical trial in 12 Chinese cities to evaluate its impact on HIV seroincidence among Chinese MSM. As a team of an expert network of American and Chinese researchers and community members with rich knowledge in the subject domains and substantial experience in China, we will develop a culturally competent and potentially effective intervention packages for Chinese MSM at the end of this project. The rapid rise of HIV epidemic among Chinese MSM and the comprehensive disease prevention networks in China provide unique environment for conducting a large scale community-based clinical trial. PUBLIC HEALTH RELEVANCE: These sustainable intervention packages, if proven feasible and effective, will be adopted in future research and public health programs for preventing new HIV infections and improving the lives of HIV-infected MSM. This MP3 grant is to develop and pilot test a multi-components prevention intervention package of Test and Link-to-Care (TLC) strategy to reduce HIV transmission by engaging expanded HIV testing with prompt initiation of risk reduction intervention and optimal antiretroviral treatment among a HIV high risk but largely ignored population-men who have sex with men (MSM) in China. These sustainable intervention packages, if proven feasible and effective, will be adopted in future research and public health programs for preventing new HIV infections and improving the lives of HIV-infected MSM in China and other parts of the world.

说明(申请人提供)：没有被证明有效的预防干预措施，专门针对男男性行为(MSM)人群。捆绑部分措施和优化干预措施组合可能会对艾滋病毒血清发病率产生重大影响。这项研究的目标是开发和中试一套基于测试和链接护理(TLC)的干预措施，为未来的社区水平随机临床试验做准备。本研究的具体目的是：(1)对文献进行系统的回顾和数学建模，以指导中国地区男男性接触者艾滋病预防措施的选择；(2)开展初步研究，评价中国男男性接触者多组分TLC干预方案的可行性、可接受性和初步效果；(3)提炼和最终确定菜单驱动的艾滋病预防方案，并在中国12个城市设计一项多点随机临床试验，以评估其对中国男男性接触者艾滋病血清发病率的影响。作为一个由中美研究人员和社区成员组成的专家网络团队，他们在学科领域拥有丰富的知识和在中国方面的丰富经验，我们将在本项目结束时为中国MSM开发一套具有文化能力和潜在有效的干预方案。艾滋病在中国男男性接触者中的迅速流行和中国完善的疾病预防网络为开展大规模社区临床试验提供了独特的环境。 公共卫生相关性：如果这些可持续干预方案被证明是可行和有效的，将被用于未来的研究和公共卫生计划，以防止新的艾滋病毒感染和改善感染艾滋病毒的男男性行为者的生活。 这笔MP3拨款是为了开发和试行测试和联系护理(TLC)战略的多成分预防干预方案，通过对中国艾滋病高危但基本上被忽视的男男性行为者(MSM)进行扩大艾滋病毒检测，迅速启动降低风险干预和最佳抗逆转录病毒治疗来减少艾滋病毒传播。这些可持续的干预方案如果被证明是可行和有效的，将被用于未来的研究和公共卫生项目，以防止新的艾滋病毒感染，并改善中国和世界其他地区感染艾滋病毒的男男性行为者的生活。