Multi-component HIV Intervention Packages for Chinese MSM

描述（由申请人提供）：目前尚无针对男男性行为（MSM）人群的有效预防干预措施。将部分措施捆绑在一起并优化干预措施的组合可能会对艾滋病毒血清发病率产生重大影响。本研究的目的是开发和试点测试的测试和链接到护理（TLC）为基础的干预措施，为未来的社区水平的随机临床试验的准备包。具体目标是：（1）对文献进行系统回顾，并建立数学模型，以指导我国MSM人群艾滋病预防干预措施的选择;（2）开展多组分TLC干预方案在我国MSM人群中的可行性、可接受性和初步效果的初步研究;（3）完善并最终确定菜单驱动的HIV预防包，并在中国12个城市设计多中心随机临床试验，以评估其对中国MSM人群HIV血清学发病率的影响。作为一个由美国和中国的研究人员和社区成员组成的专家网络，他们在该领域拥有丰富的知识和在中国的丰富经验，我们将在本项目结束时为中国的MSM制定一个文化上有能力和潜在有效的干预方案。中国MSM人群中HIV流行的迅速上升和中国完善的疾病预防网络为开展大规模的社区临床试验提供了独特的环境。

DESCRIPTION (provided by applicant): There is no proven effective prevention intervention specifically for men who have sex with men (MSM) population. Bundling partial measures and optimize combinations of interventions may have a substantial impact on HIV seroincidence. The goal of this study is to develop and pilot test a package of Test and Link-to-Care (TLC)-based interventions for preparation of future community-level randomized clinical trial. The specific aims are: (1) To conduct a systematic review of the literature and mathematical modeling to guide the selection of HIV prevention interventions for MSM in China; (2) To conduct a pilot study to evaluate the feasibility, acceptability and initial efficacy of a multi-component TLC intervention packages among MSM in China; and (3) To refine and finalize menu-driven HIV prevention packages and design a multi-site randomized clinical trial in 12 Chinese cities to evaluate its impact on HIV seroincidence among Chinese MSM. As a team of an expert network of American and Chinese researchers and community members with rich knowledge in the subject domains and substantial experience in China, we will develop a culturally competent and potentially effective intervention packages for Chinese MSM at the end of this project. The rapid rise of HIV epidemic among Chinese MSM and the comprehensive disease prevention networks in China provide unique environment for conducting a large scale community-based clinical trial.