Multi-component HIV Intervention Packages for Chinese MSM

描述（由申请人提供）：目前尚无针对男男性行为者（MSM）人群的有效预防干预措施。将部分措施捆绑在一起并优化干预措施组合可能对艾滋病毒血清发病率产生重大影响。本研究的目的是开发和试点测试一揽子基于测试和链接到护理（TLC）的干预措施，为未来的社区水平随机临床试验做准备。具体目的是：(1)对相关文献进行系统综述，建立数学模型，指导中国男男性行为者艾滋病预防干预措施的选择；(2)开展一项试点研究，评估多组分TLC干预包在中国男男性行为人群中的可行性、可接受性和初步效果；(3)完善和完善菜单驱动的HIV预防套餐，并在中国12个城市设计多地点随机临床试验，评估其对中国MSM人群HIV血清发病率的影响。作为一个由中美两国研究人员和社区成员组成的专家网络团队，我们拥有丰富的学科知识和在中国的丰富经验，我们将在项目结束时为中国的MSM开发一套具有文化能力和潜在有效性的干预方案。中国男男性接触者中艾滋病流行的迅速上升和中国的综合疾病预防网络为开展大规模社区临床试验提供了独特的环境。

DESCRIPTION (provided by applicant): There is no proven effective prevention intervention specifically for men who have sex with men (MSM) population. Bundling partial measures and optimize combinations of interventions may have a substantial impact on HIV seroincidence. The goal of this study is to develop and pilot test a package of Test and Link-to-Care (TLC)-based interventions for preparation of future community-level randomized clinical trial. The specific aims are: (1) To conduct a systematic review of the literature and mathematical modeling to guide the selection of HIV prevention interventions for MSM in China; (2) To conduct a pilot study to evaluate the feasibility, acceptability and initial efficacy of a multi-component TLC intervention packages among MSM in China; and (3) To refine and finalize menu-driven HIV prevention packages and design a multi-site randomized clinical trial in 12 Chinese cities to evaluate its impact on HIV seroincidence among Chinese MSM. As a team of an expert network of American and Chinese researchers and community members with rich knowledge in the subject domains and substantial experience in China, we will develop a culturally competent and potentially effective intervention packages for Chinese MSM at the end of this project. The rapid rise of HIV epidemic among Chinese MSM and the comprehensive disease prevention networks in China provide unique environment for conducting a large scale community-based clinical trial.