Multi-component HIV Intervention Packages for Chinese MSM

说明(申请人提供)：没有被证明有效的预防干预措施，专门针对男男性行为(MSM)人群。捆绑部分措施和优化干预措施组合可能会对艾滋病毒血清发病率产生重大影响。这项研究的目标是开发和中试一套基于测试和链接护理(TLC)的干预措施，为未来的社区水平随机临床试验做准备。本研究的具体目的是：(1)对文献进行系统的回顾和数学建模，以指导中国地区男男性接触者艾滋病预防措施的选择；(2)开展初步研究，评价中国男男性接触者多组分TLC干预方案的可行性、可接受性和初步效果；(3)提炼和最终确定菜单驱动的艾滋病预防方案，并在中国12个城市设计一项多点随机临床试验，以评估其对中国男男性接触者艾滋病血清发病率的影响。作为一个由中美研究人员和社区成员组成的专家网络团队，他们在学科领域拥有丰富的知识和在中国方面的丰富经验，我们将在本项目结束时为中国MSM开发一套具有文化能力和潜在有效的干预方案。艾滋病在中国男男性接触者中的迅速流行和中国完善的疾病预防网络为开展大规模社区临床试验提供了独特的环境。

DESCRIPTION (provided by applicant): There is no proven effective prevention intervention specifically for men who have sex with men (MSM) population. Bundling partial measures and optimize combinations of interventions may have a substantial impact on HIV seroincidence. The goal of this study is to develop and pilot test a package of Test and Link-to-Care (TLC)-based interventions for preparation of future community-level randomized clinical trial. The specific aims are: (1) To conduct a systematic review of the literature and mathematical modeling to guide the selection of HIV prevention interventions for MSM in China; (2) To conduct a pilot study to evaluate the feasibility, acceptability and initial efficacy of a multi-component TLC intervention packages among MSM in China; and (3) To refine and finalize menu-driven HIV prevention packages and design a multi-site randomized clinical trial in 12 Chinese cities to evaluate its impact on HIV seroincidence among Chinese MSM. As a team of an expert network of American and Chinese researchers and community members with rich knowledge in the subject domains and substantial experience in China, we will develop a culturally competent and potentially effective intervention packages for Chinese MSM at the end of this project. The rapid rise of HIV epidemic among Chinese MSM and the comprehensive disease prevention networks in China provide unique environment for conducting a large scale community-based clinical trial.