Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging

描述(由申请人提供)：线粒体是重要的细胞器，长期以来一直以其在ATP生产中的中心功能而闻名，以及许多其他合成代谢和分解代谢途径。近年来，在我们对线粒体的基本生物学和功能的理解上取得了令人兴奋的新突破。新的研究发现，线粒体在细胞生物学和疾病的许多方面都发挥着关键作用，远远超出了它们在新陈代谢中的核心角色，包括控制细胞生长和分化、氧气感应和ROS信号，以及作为先天免疫和炎症反应的枢纽。这些进展使人们认识到，线粒体对人类疾病和衰老的贡献是多方面的，比之前预期的更深远。因此，本提案寻求支持的2013年FASEB会议“线粒体生物发生和动力学在健康、疾病和老龄化中的作用”的重要性是显而易见的。越来越有必要在了解和研究细胞器基本生物学的研究人员与从事这些线粒体新前沿的研究人员之间建立互动，目的是将这些活动融入更好地理解线粒体功能障碍如何导致人类疾病和衰老。这一领域无疑是当代生物学和医学中最令人兴奋的研究课题之一。本次会议的主要议题是：1)基础线粒体生物学；2)线粒体疾病；3)线粒体与衰老和长寿；4)线粒体生物学和医学的新前沿。这次会议将汇集具有广泛专业知识的科学家，从老牌研究人员到研究生，介绍和讨论线粒体生物学及其与疾病和衰老的联系的最新进展。会议将促进基础和生物医学科学的讨论，并激发翻译研究机会。目标是：1)组织和支持线粒体生物学和功能障碍领域的会议。会议将于2013年6月16日至21日在蒙大拿州Big Sky的FASEB会议地点举行；2)促进对线粒体生物学和线粒体功能障碍在人类疾病和衰老中的不同方面感兴趣的基础科学家和翻译科学家之间的科学思想交流，重点是刺激协作方法和跨领域刺激；3)鼓励和促进初级研究人员、妇女和少数群体的参与，目的是将他们整合到这个重要且快速增长的领域。

DESCRIPTION (provided by applicant): Mitochondria are essential cellular organelles, long noted for their central function in ATP production, as well as many other anabolic and catabolic pathways. Exciting new breakthroughs in our understanding of basic biology and function of mitochondria have taken place in recent years. New research has identified mitochondria as key players in many aspects of cell biology and disease, well beyond their central role in metabolism, including control of cell growth and differentiation, oxygen sensing and ROS signaling, and as hubs of the innate immune and inflammatory responses. These advances have led to realization that the contribution of mitochondria to human disease and aging is multifaceted and more far-reaching than previously anticipated. Therefore, the importance of the 2013 FASEB conference "Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging", for which this proposal seeks support, is clear. There is a growing need to create interactions between investigators that understand and study the basic biology of the organelle with those engaged at these new frontiers of mitochondria, with the goal of melding these activities into a better understanding of how mitochondrial dysfunction contributes to human disease and aging. This area is undoubtedly one of the most exciting research topics in contemporary biology and medicine. The major topics that will be covered in this meeting are: 1) Basic Mitochondrial Biology, 2) Mitochondrial Diseases; 3) Mitochondria in Aging and Longevity; 4) New Frontiers in Mitochondrial Biology and Medicine. The meeting will bring together scientists with a broad range of expertise, ranging from established investigators to graduate students, to present and discuss the most recent advances in the biology of mitochondria and its links to disease and aging. The conference will facilitate discussion of basic and biomedical science as well as stimulate translational research opportunities. The goals will be: 1) to organize and support a conference in the field of mitochondrial biology and dysfunction. The conference will be held June 16-21, 2013, at the FASEB conference site in Big Sky, Montana; 2) to promote the exchange of scientific ideas among basic and translational scientists interested in diverse aspects of mitochondrial biology and mitochondrial dysfunction in human disease and in aging, with a focus on stimulate collaborative approaches and cross-field stimulation; 3) to encourage and promote participation by junior investigators, women and minorities, with the goal of integrating them in this important and rapidly growing field.