Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging

描述（由申请人提供）：线粒体是重要的细胞器，长期以来以其在ATP产生以及许多其他合成代谢和分解代谢途径中的中心功能而闻名。近年来，我们对线粒体的基本生物学和功能的理解取得了令人兴奋的新突破。新的研究已经确定线粒体是细胞生物学和疾病许多方面的关键参与者，远远超出了它们在代谢中的核心作用，包括控制细胞生长和分化，氧传感和ROS信号传导，以及作为先天免疫和炎症反应的中心。这些进展使人们认识到，线粒体对人类疾病和衰老的贡献是多方面的，比以前预期的更深远。因此，2013年FASEB会议“健康，疾病和衰老中的线粒体生物发生和动力学”的重要性是显而易见的，本提案寻求支持。越来越需要在了解和研究细胞器基本生物学的研究人员与从事线粒体这些新前沿的研究人员之间建立互动，目的是将这些活动融合到更好地了解线粒体功能障碍如何导致人类疾病和衰老中。这一领域无疑是当代生物学和医学中最令人兴奋的研究课题之一。本次会议将涉及的主要议题是：1）基本线粒体生物学，2）线粒体疾病; 3）衰老和长寿中的线粒体; 4）线粒体生物学和医学的新前沿。会议将汇集具有广泛专业知识的科学家，从知名研究人员到研究生，介绍和讨论线粒体生物学的最新进展及其与疾病和衰老的联系。会议将促进基础和生物医学科学的讨论，并刺激转化研究的机会。目标是：1）组织和支持线粒体生物学和功能障碍领域的会议。会议将于2013年6月16日至21日在蒙大拿州Big Sky的FASEB会议现场举行; 2）促进对人类疾病和衰老中线粒体生物学和线粒体功能障碍的各个方面感兴趣的基础和翻译科学家之间的科学思想交流，重点是激励协作方法和跨领域刺激; 3）鼓励和促进初级调查员、妇女和少数民族的参与，目标是将他们纳入这一重要和迅速发展的领域。

DESCRIPTION (provided by applicant): Mitochondria are essential cellular organelles, long noted for their central function in ATP production, as well as many other anabolic and catabolic pathways. Exciting new breakthroughs in our understanding of basic biology and function of mitochondria have taken place in recent years. New research has identified mitochondria as key players in many aspects of cell biology and disease, well beyond their central role in metabolism, including control of cell growth and differentiation, oxygen sensing and ROS signaling, and as hubs of the innate immune and inflammatory responses. These advances have led to realization that the contribution of mitochondria to human disease and aging is multifaceted and more far-reaching than previously anticipated. Therefore, the importance of the 2013 FASEB conference "Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging", for which this proposal seeks support, is clear. There is a growing need to create interactions between investigators that understand and study the basic biology of the organelle with those engaged at these new frontiers of mitochondria, with the goal of melding these activities into a better understanding of how mitochondrial dysfunction contributes to human disease and aging. This area is undoubtedly one of the most exciting research topics in contemporary biology and medicine. The major topics that will be covered in this meeting are: 1) Basic Mitochondrial Biology, 2) Mitochondrial Diseases; 3) Mitochondria in Aging and Longevity; 4) New Frontiers in Mitochondrial Biology and Medicine. The meeting will bring together scientists with a broad range of expertise, ranging from established investigators to graduate students, to present and discuss the most recent advances in the biology of mitochondria and its links to disease and aging. The conference will facilitate discussion of basic and biomedical science as well as stimulate translational research opportunities. The goals will be: 1) to organize and support a conference in the field of mitochondrial biology and dysfunction. The conference will be held June 16-21, 2013, at the FASEB conference site in Big Sky, Montana; 2) to promote the exchange of scientific ideas among basic and translational scientists interested in diverse aspects of mitochondrial biology and mitochondrial dysfunction in human disease and in aging, with a focus on stimulate collaborative approaches and cross-field stimulation; 3) to encourage and promote participation by junior investigators, women and minorities, with the goal of integrating them in this important and rapidly growing field.