Inflammatory mediators of liver injury in chronic hepatitis C

慢性丙型肝炎肝损伤的炎症介质

• 批准号: nhmrc : 1032096
• 负责人: A/Pr Amany Zekry
• 金额: $ 23.29万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inflammatory-mediators-liver-hepatitis-c/110840
• 关键词: Inflammatory; mediators; liver; injury; chronic

Presently, liver disease from chronic hepatitis C and obesity represents a major health problem. Overall, approximately 50% of Australians with chronic hepatitis C are obese and these patients are at significantly increased risk of rapidly progressing to liver failure. It is now recognized that fat derived factors play an important role in regulating inflammatory responses. This grant proposal aims to gain insight into how liver and fat derived inflammatory factors interact to promote increased liver damage in chronic hepatitis C and obesity.

目前，慢性丙型肝炎和肥胖引起的肝脏疾病是一个主要的健康问题。总体而言，大约50%的澳大利亚慢性丙型肝炎患者肥胖，这些患者迅速发展为肝衰竭的风险显著增加。现在已经认识到脂肪衍生因子在调节炎症反应中起着重要作用。这项拨款提案旨在深入了解肝脏和脂肪源性炎症因子如何相互作用，促进慢性丙型肝炎和肥胖患者肝损伤的增加。