Project 2

项目2 酵母菌落发育的多尺度时空动态 导言。 在生命系统中，个体的特征，包括对疾病的敏感性或对治疗的反应等特征，是由在不同组织规模上运作的过程的耦合决定的。例如，一个人的DNA序列限制了控制其细胞状态和行为的分子网络，这反过来又决定了多细胞结构的形式和功能。微生物，包括酵母，传统上被用作在单细胞水平上研究基本细胞过程的模型。然而，单细胞生物体可以形成多细胞群落，并分化成专门的结构，以造福于种群。在一些野生的酿酒酵母分离株中，菌落(从单个细胞开始分裂，有丝分裂成为-10[8]细胞的结构)经历了形态转变，其特征是复杂的

Project 2 Multiscale spatial and temporal dynamics of yeast colony development Introduction. In living systems, the characteristics of an individual, including traits such as susceptibility to disease or response to therapy, are determined by the coupling of processes that function at different scales of organization. For example, an individual's DNA sequence constrains the molecular networks that govern its cellular states and behaviors, which in turn determine the form and functions of multi-cellular structures. Microorganisms, including the yeast Saccharomyces cerevisiae, are traditionally used as models for investigating basic cellular processes at the unicellular level. However, unicellular organisms can form multi-cellular communities and differentiate into specialized structures to benefit the population. In some wild isolates of S. cerevisiae colonies (which start from a single cell and divide mitotically to become a structure of -10[8] cells) undergo a morphological transition characterized by complex patterns of