FASEB SRC on Molecular Mechanism and Physiological Consequences of Protein Aggreg

描述(申请人提供)：虽然淀粉样蛋白与多种人类疾病的联系早已被认识到，但控制淀粉样蛋白出现和放大的确切分子途径，这些事件在疾病发生和发展中的因果关系，以及这些过程对治疗中断的敏感性，仍然是广泛的跨学科研究的主题的重大悬而未决的问题。这份R13提案寻求对FASEB夏季研究会议“蛋白质聚集的分子机制和生理后果”的核心支持。我们的计划是1995年开始的一系列会议中的第九次，我们的计划寻求利用可用的蛋白质、系统和方法的广度来促进我们对与淀粉样变相关的全面生物学现象的理解，目标是最终干预这些过程。会议将于2013年6月23日至28日在蒙大拿州的Big Sky举行，将提供一个论坛，介绍和讨论新出现的进展，并建立合作关系，以应对该领域的重大挑战。较小的尺寸(通常 这次会议及其对淀粉样蛋白发生的全方位研究的创新展示提供了一个独特的机会来捕捉和整合这一过程的复杂性，并协同推动该领域的发展。

DESCRIPTION (provided by applicant): While the association of amyloid with a variety of human diseases has been long appreciated, the precise molecular pathways governing amyloid appearance and amplification, the causality of these events in disease initiation and progression, and the sensitivity of these processes to therapeutic disruption remain significant open questions that are the subject of wide-ranging, cross-disciplinary research. This R13 proposal seeks core support for a FASEB Summer Research Conference on "Molecular Mechanisms and Physiological Consequences of Protein Aggregation." The ninth conference in a series that began in 1995, our program seeks to leverage the breadth of proteins, systems, and approaches available to advance our understanding of the full range of biological phenomena linked to amyloidogenesis with the goal of ultimately intervening in these processes. The conference, to be held in Big Sky, Montana from June 23-28, 2013, will provide a forum for the presentation and discussion of newly arising advances and for establishing collaborative relationships to address the grand challenges in the field. The small size (typically 150 participants) of this conference and its innovative representation of the full range of research on amyloidogenesis provides a unique opportunity to capture and integrate the complexity of this process and synergistically advance the field.