FASEB SRC on Molecular Mechanism and Physiological Consequences of Protein Aggreg

FASEB SRC 关于蛋白质聚集体的分子机制和生理后果

• 批准号: 8597867
• 负责人: TRICIA R. SERIO
• 金额: $ 4.18万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597867
• 关键词: Address; Affect; Alzheimer' s Disease; Amyloid; Amyloid deposition; Amyloidosis; Amyotrophic Lateral Sclerosis; Appearance; Area; Biochemical; Biological Models; Biological Phenomena; Bovine Spongiform Encephalopathy; Brain; Cell physiology; Cells; Complex; Cytoskeleton; Development; Diagnostic; Disease; Disease Progression; Economic Burden; Employee Strikes; Etiology; Event; Familial Amyloid Neuropathies; Fostering; Goals; Hormones; Human; Huntington Disease; In Vitro; Individual; Link; Modeling; Molecular; Montana; Nature; Nerve Degeneration; Non-Insulin-Dependent Diabetes Mellitus; Parkinson Disease; Participant; Pathology; Pathway interactions; Physicians; Physiological; Physiology; Prion Diseases; Process; Property; Proteins; Publications; Quality Control; Research; Research Personnel; Scientist; Series; Structural Biologist; Synapses; System; Therapeutic; Thermodynamics; Triage; Ursidae Family; Work; amyloid formation; amyloid structure; amyloidogenesis; cell type; design; effective therapy; experience; flexibility; human disease; in vivo; innovation; mathematical model; nervous system disorder; programs; protein aggregate; protein aggregation; protein folding; protein misfolding; public health relevance; symposium

DESCRIPTION (provided by applicant): While the association of amyloid with a variety of human diseases has been long appreciated, the precise molecular pathways governing amyloid appearance and amplification, the causality of these events in disease initiation and progression, and the sensitivity of these processes to therapeutic disruption remain significant open questions that are the subject of wide-ranging, cross-disciplinary research. This R13 proposal seeks core support for a FASEB Summer Research Conference on "Molecular Mechanisms and Physiological Consequences of Protein Aggregation." The ninth conference in a series that began in 1995, our program seeks to leverage the breadth of proteins, systems, and approaches available to advance our understanding of the full range of biological phenomena linked to amyloidogenesis with the goal of ultimately intervening in these processes. The conference, to be held in Big Sky, Montana from June 23-28, 2013, will provide a forum for the presentation and discussion of newly arising advances and for establishing collaborative relationships to address the grand challenges in the field. The small size (typically 150 participants) of this conference and its innovative representation of the full range of research on amyloidogenesis provides a unique opportunity to capture and integrate the complexity of this process and synergistically advance the field.

描述（由申请人提供）： 虽然淀粉样蛋白与多种人类疾病的关联早已被认识到，但控制淀粉样蛋白出现和扩增的精确分子途径、这些事件在疾病起始和进展中的因果关系以及这些过程对治疗中断的敏感性仍然是重要的开放性问题，这些问题是广泛的跨学科研究的主题。这个R13提案寻求FASEB夏季研究会议“蛋白质聚集的分子机制和生理后果”的核心支持。“在1995年开始的系列会议中的第九次会议，我们的计划旨在利用蛋白质，系统和方法的广度，以促进我们对与淀粉样蛋白生成相关的全方位生物现象的理解，最终干预这些过程。会议将于2013年6月23日至28日在蒙大拿州的大天空举行，将为介绍和讨论新出现的进展以及建立合作关系以应对该领域的重大挑战提供一个论坛。小尺寸（通常 150名与会者）及其对淀粉样蛋白生成全方位研究的创新代表性，为捕捉和整合这一过程的复杂性并协同推进该领域提供了独特的机会。