Five Year Outcomes from Acute Lung Injury

急性肺损伤的五年结果

• 批准号: 8523195
• 负责人: Peter J. Pronovost
• 金额: $ 19.33万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-11 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8523195
• 关键词: Acute; Acute Lung Injury; Adrenal Cortex Hormones; Adult Respiratory Distress Syndrome; Anxiety; Blood capillaries; Caring; Cessation of life; Clinical Research; Cohort Studies; Critical Illness; Death Rate; Delirium; Diffuse; Epidemiology; Frequencies; Funding; Future; Goals; Grant; HIV Infections; Hypoxia; Incidence; Intensive Care; Intensive Care Units; Intervention; Intervention Studies; Knowledge; Lead; Learning; Left; Longitudinal Studies; Lung; Mechanical ventilation; Medical; Mental Depression; Mental Health; Mental disorders; Mentors; Mid-Career Clinical Scientist Award (K24); Morbidity - disease rate; Muscle Weakness; Outcome; Patients; Persons; Physical Function; Post-Traumatic Stress Disorders; Prevalence; Psyche structure; Public Health; Quality of life; Recovery; Research; Research Design; Research Infrastructure; Research Proposals; Respiratory Failure; Risk Factors; Sampling; Sepsis; Severities; Survivors; Symptoms; Syndrome; United States National Institutes of Health; capillary; cohort; design; epidemiology study; experience; follow-up; functional status; improved; malignant breast neoplasm; mortality; nutrition; patient oriented research; physical conditioning; prospective; randomized trial; research study

Acute Lung Injury (ALI) is a syndrome characterized by acute, diffuse pulmonary capillary leak resulting in hypoxic respiratory failure. ALI imposes a significant public health burden with an incidence of 86 per 100,000 person years and a total number of deaths similar to breast cancer or HIV infection. Due to advances in medical care, the mortality rate for ALI has decreased from -70% to -40%. Patients who previously may have died now survive ALI; however, their recovery is often long and complicated. Research studying the long-term outcomes of these ALI survivors has become increasingly important. The present application is a third submission for a K24 award. The PI is a leader is patient -oriented research in critically ill patients especially those with ALI, and has an outstanding record of mentoring trainees. The goal of this proposal is to learn how existing ICU therapies can be used to minimize long-term physical and mental health morbidities and improve patients' functional status and quality of life after ALI. We propose to extend our existing NIH funded cohort study, which follows patients for 2 years after ALI, to allow 5-year follow-up. Specifically, we will study the epidemiology of muscle weakness, and symptoms of anxiety, depression and post-traumatic stress disorder at up to 5 years after ALI [Aims 1a and 2a] and the association of these sequelae with limitations in patients' physical function and quality of life. We will then determine the association of nutrition and corticosteroids in the ICU with long-term muscle weakness[Aim 1b]. We also will determine the association of delirium and corticosteroids in the ICU with long-term symptoms of post-traumatic stress disorder [Aim 2b]. A number of research opportunities exist for trainees. This research proposal describes a new cohort study of ALI patients who will be followed for 5 years. This research will provide new knowledge regarding the frequency of morbidities after ALI, their consequences for patients, and how nutrition, corticosteroids and delirium in the ICU may reduce or exacerbate these morbidities up to 5 years after ALI. The study will add to our infrastructure for trainees to participate in clinical research and to design future studies, including intervention studies, to improve outcomes in ALI patients.

急性肺损伤（ALI）是一种以急性弥漫性肺毛细血管渗漏导致缺氧呼吸衰竭为特征的综合征。急性呼吸道感染对公共卫生造成了沉重负担，发病率为每10万人每年86例，死亡总人数与乳腺癌或艾滋病毒感染相似。由于医疗保健的进步，急性呼吸道感染的死亡率已从-70%下降到-40%。以前可能已经死亡的患者现在可以存活；然而，他们的恢复往往是漫长而复杂的。研究这些急性脑损伤幸存者的长期预后变得越来越重要。

项目成果

Evaluating Safety Initiatives in Healthcare.

评估医疗保健领域的安全举措。

• DOI: 10.1007/s40140-014-0059-4
• 发表时间: 2014
• 期刊: Current anesthesiology reports
• 影响因子: 1.3
• 作者: Latif,Asad;Holzmueller,ChristineG;Pronovost,PeterJ
• 通讯作者: Pronovost,PeterJ

Hospital Readmission and Subsequent Decline in Long-Term Survivors of Acute Respiratory Distress Syndrome.

急性呼吸窘迫综合征长期幸存者的再入院和随后的下降。

• DOI: 10.4037/ajcc2019580
• 发表时间: 2019
• 期刊: American journal of critical care : an official publication, American Association of Critical-Care Nurses
• 作者: Wozniak,AmyW;Pfoh,ElizabethR;Dinglas,VictorD;Pronovost,PeterJ;Needham,DaleM;Colantuoni,Elizabeth
• 通讯作者: Colantuoni,Elizabeth