Physiology and Surgery

生理学和外科

• 批准号: 8452823
• 负责人: MARK ALAN SUSSMAN
• 金额: $ 22.52万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8452823
• 关键词: Adoptive Cell Transfers; Adoptive Transfer; Animals; Area; Biological Models; Cardiac; Cardiac Surgery procedures; Cardiology; Caring; Cells; Cellular biology; Collaborations; Complement; Complex; Core Facility; Data; Data Analyses; Dimensions; Doctor of Philosophy; Echocardiography; Ensure; Equipment; Failure; Follow-Up Studies; Funding; Generations; Genetic; Genomics; Healed; Health Status; Heart; Histology; Home environment; Housing; Human Resources; Hypertrophy; Image; Individual; Infarction; Injection of therapeutic agent; Institutes; Institution; Instruction; Intervention; Ischemia; Location; Modeling; Molecular; Monitor; Movement; Mus; Myocardial; Myocardial Infarction; Operative Surgical Procedures; Participant; Pathology; Performance; Persons; Physiological; Physiology; Positioning Attribute; Postoperative Period; Preparation; Procedures; Process; Property; Publications; Reperfusion Therapy; Research; Research Personnel; Resources; Scientist; Services; Specialist; Structure; Supervision; Surgeon; Technical Expertise; Techniques; Technology; Testing; Time; Training; United States National Institutes of Health; Work; base; constriction; design; electric impedance; experience; healing; heart function; hemodynamics; human disease; in vivo; in vivo Model; member; pressure; programs; research study; skills

The Physiology / Surgery Core (PSC; Core C), used by all of the Projects of this PPG, will offer integrated services for assessing heart function and structure in settings that mimic cardiac pathology in mice. Accordingly, Core C will maintain equipment and provide staffing to offer Projects the following services: 1) Physiology: echocardiography, invasive hemodynamics, isolated working heart preparation, and 2) Surgery: in vivo myocardial infarction, reperfusion, transaortic constriction, and intramyocardial adoptive transfer cell injection. The PSC is centrally located in the SDSU BioScience Center, which houses the SDSU Heart Institute labs and administrative offices. The PSC is composed of fully equipped surgery and physiology suites and dedicated mouse holding rooms. PPG investigators both institutions will be able to fully utilize PSC resources with "on demand" availability of two part-time trained cardiac surgeons, a physiology technician, and a mouse husbandry specialist. All required equipment including a Visualsonics Vevo 770 and Scisense hemodynamic assessment package are in place and operational in the PSC. The PSC is under the direction of Dr. Mark Sussman, who has a legacy of publications in the techniques offered by core and is well versed in administration of such services for Program participants. Dr. Glembotski brings his decades of experience in mouse physiology and surgery as co-Director of the PSC. An additional advantage of the PSC is that it adjoins the SDSU Heart Institute Mouse Genetics Center, which facilitates the generation and use of genetically modified mice by Projects. The PSC was designed specifically to serve this multi-institutional PPG; accordingly, it will maximize collaborations between projects, thus enhancing the synergy of this integrated research program. The PSC complements and integrates with the Cell Biology / Histology Core (CBHC) by serving as the location where principles discovered using cells generated with cells from the CBHC will be assessed in a pathophysiological in vivo context that mimics cardiomyopathic conditions. The PSC will be equally used by all four Projects of the Program

生理学/外科核心（PSC;核心C），用于本PPG的所有项目，将提供综合服务，用于在模拟小鼠心脏病理的环境中评估心脏功能和结构。因此，核心C将维护设备并提供人员，以向项目提供以下服务：1）生理学：超声心动图、侵入性血流动力学、离体工作心脏准备，以及2）手术：体内心肌梗死、再灌注、经主动脉缩窄和心肌内过继转移细胞注射。PSC位于SDSU生物科学中心的中心，该中心设有SDSU心脏研究所实验室和行政办公室。PSC由设备齐全的手术室和生理室以及专用小鼠饲养室组成。PPG研究人员和两个机构将能够充分利用PSC资源，“按需”提供两名兼职训练有素的心脏外科医生、一名生理学技术人员和一名小鼠饲养专家。所有所需设备（包括Visualsonics Vevo 770和Scisense血流动力学评估包）均已到位，并在PSC中运行。PSC由Mark Sussman博士领导，他在核心技术方面有着丰富的出版物，并且精通为计划参与者提供此类服务的管理。Glembotski博士带来了他在小鼠生理学和手术方面数十年的经验，担任PSC的联合主任。PSC的另一个优势是它毗邻SDSU心脏研究所小鼠遗传学中心，该中心促进了项目转基因小鼠的产生和使用。PSC是专门为服务于这个多机构PPG而设计的;因此，它将最大限度地提高项目之间的合作，从而增强这个综合研究计划的协同作用。PSC补充并整合了细胞生物学/组织学核心（CBHC），作为使用来自CBHC的细胞产生的细胞发现的原理将在模拟心肌病状况的病理生理学体内背景下进行评估的位置。PSC将被该计划的所有四个项目平等使用