Cardiomyocyte Proliferation and Ventricular Morphogenesis
Cardiomyocyte Proliferation and Ventricular Morphogenesis
批准号:
8610438
负责人:
Henry M Sucov
金额:
$2.22万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-07-01 至 2016-04-30
关键词:
AccountingAddressAdultBiological AssayBlood VesselsCXCL12 geneCardiac MyocytesCause of DeathCell CountCoculture TechniquesCommunicationCoronaryCouplesDataDevelopmentEmbryoEmbryonic HeartEndocardiumEndothelial CellsEpicardiumErythropoietinFetal LiverGeneticGenetically Engineered MouseGrowthHeartHeart DiseasesHepaticIGF2 geneIn VitroInsulin-Like Growth Factor ReceptorInterleukin-2Knock-outLengthLigandsLiverMitogensModelingMorphogenesisMusMutagenesisMyocardiumNatural regenerationProcessProliferatingReceptor GeneRecruitment ActivityResearchRetinoic Acid ReceptorRoleSignal TransductionSourceSurfaceTestingTimeTissuesTretinoinTubeVascular blood supplyVentricularWestern WorldWorkascending aortabasecardiogenesiscell typechemokinegenetic manipulationin vitro Assayin vivomouse developmentmutantreceptorreceptor functionrepairedresearch studytissue/cell culturevasculogenesis
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): The broad objective of this work is to understand the basis of formation of the ventricular chamber of the heart. This project specifically considers two
distinct processes: how do cardiac muscle cells (cardiomyocytes) expand in number (proliferate), and how do coronary blood vessels form. These processes are related by virtue of being controlled by signals from the outer layer of the heart, a cell type called the epicardium. This project seeks to understand the role and mechanistic basis of these signals, primarily utilizing genetically engineered mice, explanted embryonic mouse tissue, and tissue culture cells to conduct this research.
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Cardiomyocyte Proliferation and Ventricular Morphogenesis
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批准号:9927738
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项目类别:
-
资助金额:$38.89万
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财政年份:2019
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负责人:Henry M Sucov
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依托单位:
The complex genetics of heart regeneration
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批准号:10343771
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项目类别:
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资助金额:$52.1万
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财政年份:2019
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负责人:Henry M Sucov
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依托单位:
The complex genetics of heart regeneration
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批准号:9891094
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项目类别:
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资助金额:$52.1万
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财政年份:2019
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte heterogeneity and aging
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批准号:8883067
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项目类别:
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资助金额:$24.75万
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财政年份:2015
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte heterogeneity and aging
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批准号:9065465
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项目类别:
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资助金额:$20.63万
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财政年份:2015
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负责人:Henry M Sucov
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依托单位:
TGFb and Cardiac Neural Crest Cell Fate and Function
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批准号:7101433
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项目类别:
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资助金额:$40.72万
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财政年份:2006
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负责人:Henry M Sucov
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依托单位:
TGFb and Cardiac Neural Crest Cell Fate and Function
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批准号:7599183
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项目类别:
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资助金额:$39.57万
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财政年份:2006
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负责人:Henry M Sucov
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依托单位:
TGFb and Cardiac Neural Crest Cell Fate and Function
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批准号:7195088
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项目类别:
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资助金额:$39.57万
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财政年份:2006
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负责人:Henry M Sucov
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依托单位:
TGFb and Cardiac Neural Crest Cell Fate and Function
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批准号:7386751
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项目类别:
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资助金额:$39.57万
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财政年份:2006
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation and Ventricular Morphogenesis
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批准号:9175947
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项目类别:
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资助金额:$44.74万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation and Ventricular Morphogenesis
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批准号:8845591
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项目类别:
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资助金额:$41.68万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation and Ventricular Morphogenesis
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批准号:8452050
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项目类别:
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资助金额:$48.5万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation and Ventricular Morphogenesis
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批准号:7662958
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项目类别:
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资助金额:$40.75万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation and Ventricular Morphogenesis
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批准号:7860574
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项目类别:
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资助金额:$40.33万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation & Ventricular Morphogenesis
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批准号:6754366
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项目类别:
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资助金额:$36.56万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation and Ventricular Morphogenesis
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批准号:8295358
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项目类别:
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资助金额:$42.05万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation and Ventricular Morphogenesis
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批准号:8657082
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项目类别:
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资助金额:$43.7万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation & Ventricular Morphogenesis
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批准号:6893374
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项目类别:
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资助金额:$36.56万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation & Ventricular Morphogenesis
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批准号:7068515
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项目类别:
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资助金额:$35.7万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
Cardiomyocyte Proliferation & Ventricular Morphogenesis
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批准号:6465622
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项目类别:
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资助金额:$36.56万
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财政年份:2002
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负责人:Henry M Sucov
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依托单位:
海外基金