Malaria Research Training in South India

印度南部的疟疾研究培训

• 批准号: 8475399
• 负责人: CHANNE D GOWDA
• 金额: $ 13.28万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8475399
• 关键词: 6H,8H-3,4-dihydropyrimido(4,5-c)(1,2)oxazin-7-one; Applications Grants; Benign; Cities; Clinical; Doctor of Philosophy; Drug resistance; Educational workshop; Fostering; Goals; Health; India; Infection; Instruction; Laboratory Research; Malaria; Parasites; Pregnant Women; Principal Investigator; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Training; Resources; Students; Training; Vivax Malaria; Work; cytokine; epidemiology study; experience; field study; programs; response; symposium

Program Director/Principal Investigator (Last, First, Middle): GOWDA, Channe D PROJECT SUMMARY (See instructions): Although P. vivax infection has been commonly considered to be benign, in recent years it has been associated with severe malaria with significant fatalities. Like in other parts of the world, P. vivax malaha infection predominates in India, including South India. Despite the enormity of P. vivax associated malaria health burden, research efforts to understand the pathophysiological and immunological basis for P. vivax severe malaria have been meager. So far very little or no malaria research, especially on P. vivax, is being undertaken in South India, particularly in the Karnataka State. This Is due to lack of resources and scarcity of skilled and experienced malaria investigators. The overall goal of this grant application is to train young and meritorious PhD students from India on P. vivax malaria in Mangalore city of Southwestern Karnataka. The training will be given by a group of expert Indian and US investigators recruited to this program. Four PhD students will be trained on P. vivax malaria so that they become expert investigators and are able to take up independent studies on aspects of malaria that are relevant to the study region. The training will be imparted through field studies, laboratory research work, and by organizing symposia and workshops. Specific research aspects for training include: (i) to study the epidemiology of malaria infection and parasite drug resistance, (ii) to gain information on the clinical presentations of P. vivax malaria and cytokine responses, and (iii) to understand the impact of P. vivax infection in pregnant women. The long-term goals are to support and foster research projects taken up by trainees as independent investigators, conducting research on malaria in the Southwestern region of India.

项目主任/首席调查员(最后、第一、中间)：Gowda，Channe D 项目总结(见说明)： 虽然间日疟原虫感染通常被认为是良性的，但近年来它与严重的疟疾有关，并导致大量死亡。与世界其他地区一样，间日疟原虫感染在印度占主导地位，包括南印度。尽管间日疟与疟疾相关的健康负担巨大，但了解间日疟严重疟疾的病理生理学和免疫学基础的研究工作一直很少。到目前为止，印度南部，特别是卡纳塔克邦，很少或根本没有开展疟疾研究，特别是关于间日疟原虫的研究。这是由于缺乏资源，缺乏熟练和有经验的疟疾调查员。这项资助申请的总体目标是在卡纳塔克邦西南部的芒格洛尔市培训来自印度的年轻而有价值的博士生关于间日疟原虫的知识。 培训将由一组被招募到该项目的印度和美国专家调查人员提供。四名博士生将接受关于间日疟原虫的培训，使他们成为专家调查人员，并能够就与研究区域有关的疟疾方面进行独立研究。培训将通过实地考察、实验室研究工作以及组织研讨会和讲习班来传授。 培训的具体研究方面包括：(1)研究疟疾感染和寄生虫耐药性的流行病学；(2)获得关于间日疟原虫临床表现和细胞因子反应的信息；(3)了解间日疟原虫感染对孕妇的影响。长期目标是支持和促进由受训人员作为独立调查人员参与的研究项目，进行 印度西南部地区的疟疾研究。