Malaria Research Training in South India

项目负责人/主要研究者（最后，第一，中间）：GOWDA，Channe D 项目总结（见说明）： 虽然间日疟原虫感染通常被认为是良性的，但近年来它与严重疟疾有关，死亡率很高。与世界其他地区一样，间日疟原虫malaha感染主要发生在印度，包括印度南部。尽管间日疟原虫与疟疾健康负担相关，但了解间日疟原虫严重疟疾的病理生理学和免疫学基础的研究工作很少。到目前为止，在印度南部，特别是在卡纳塔克邦，很少或根本没有进行疟疾研究，特别是关于间日疟原虫的研究。这是由于缺乏资源和缺乏熟练和有经验的疟疾调查人员。这项赠款申请的总体目标是在卡纳塔克邦西南部的芒格洛尔市培训来自印度的年轻和有价值的博士生。 培训将由一组被招募到该计划的印度和美国专家调查员提供。将对四名博士生进行间日疟原虫疟疾方面的培训，使他们成为专家调查员，并能够独立研究与研究区域有关的疟疾问题。培训将通过实地研究、实验室研究工作以及组织专题讨论会和讲习班进行。 培训的具体研究方面包括：㈠研究疟疾感染和寄生虫抗药性的流行病学; ㈡获得关于间日疟原虫疟疾临床表现和细胞因子反应的信息; ㈢了解间日疟原虫感染对孕妇的影响。长期目标是支持和促进学员作为独立调查员开展的研究项目， 印度西南部地区的疟疾研究。

Program Director/Principal Investigator (Last, First, Middle): GOWDA, Channe D PROJECT SUMMARY (See instructions): Although P. vivax infection has been commonly considered to be benign, in recent years it has been associated with severe malaria with significant fatalities. Like in other parts of the world, P. vivax malaha infection predominates in India, including South India. Despite the enormity of P. vivax associated malaria health burden, research efforts to understand the pathophysiological and immunological basis for P. vivax severe malaria have been meager. So far very little or no malaria research, especially on P. vivax, is being undertaken in South India, particularly in the Karnataka State. This Is due to lack of resources and scarcity of skilled and experienced malaria investigators. The overall goal of this grant application is to train young and meritorious PhD students from India on P. vivax malaria in Mangalore city of Southwestern Karnataka. The training will be given by a group of expert Indian and US investigators recruited to this program. Four PhD students will be trained on P. vivax malaria so that they become expert investigators and are able to take up independent studies on aspects of malaria that are relevant to the study region. The training will be imparted through field studies, laboratory research work, and by organizing symposia and workshops. Specific research aspects for training include: (i) to study the epidemiology of malaria infection and parasite drug resistance, (ii) to gain information on the clinical presentations of P. vivax malaria and cytokine responses, and (iii) to understand the impact of P. vivax infection in pregnant women. The long-term goals are to support and foster research projects taken up by trainees as independent investigators, conducting research on malaria in the Southwestern region of India.