4D MRI Development for Cardiovascular Imaging

心血管成像 4D MRI 开发

• 批准号: 8550806
• 负责人: Jing Liu
• 金额: $ 16.84万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550806
• 关键词: 4D Imaging; Adrenergic beta-Antagonists; Anatomy; Angiography; Blood Vessels; Breathing; Cardiac; Caring; Catheters; Complex; Contrast Media; Coronary; Coronary Angiography; Coronary Arteriosclerosis; Coronary Stenosis; Coronary artery; Coronary heart disease; Development; Diastole; Dimensions; Disease; Dose; Echocardiography; Elements; Evaluation; Exposure to; Fatty acid glycerol esters; Functional disorder; Goals; Gold; Health; Health Benefit; Healthcare Systems; Heart; Image; Imaging Techniques; Injection of therapeutic agent; Ionizing radiation; Left; Left ventricular structure; Lung Transplantation; Magnetic Resonance Imaging; Measurement; Measures; Methods; Morbidity - disease rate; Morphology; Motion; Musculoskeletal; Myocardial Ischemia; Nitroglycerin; Patients; Phase; Positioning Attribute; Protocols documentation; Radial; Radiation; Reproducibility; Research; Resistance; Resolution; Right Ventricular Dysfunction; Right Ventricular Function; Right ventricular structure; Risk; Roentgen Rays; Sampling; Scanning; Slice; Structure; System; Testing; Time; Training; United States National Institutes of Health; Ventricular; Ventricular Function; Water; X-Ray Computed Tomography; artery stenosis; cardiovascular imaging; data space; fetal; heart motion; image reconstruction; imaging modality; improved; interest; method development; nephrotoxicity; novel; novel strategies; patient population; respiratory; two-dimensional

DESCRIPTION (provided by applicant): Assessments of coronary artery disease and ventricular function are crucial elements for heart health evaluation. The goal of this research is to develop 4D magnetic resonance imaging (MRI) techniques that provide a non-invasive and effective cardiac imaging examination, including assessing coronary artery disease (CAD) and both left (LV) and right ventricular (RV) function. Echocardiography (ECHO) is widely used to assess function but is limited to 2D views of the anatomy. It has poor ability to measure RV dimensions given the position, trabeculations, and complex anatomy of the RV. CT angiography (CTA) provides non-invasive assessment of CAD and ventricular function, however it involves exposure to ionizing radiation and risk of nephrotoxicity from iodinated contrast agents. Adequate CTA generally requires the use of beta blockers and is improved by the administration of nitroglycerin, both of which are contraindicated for certain patients. Coronary angiography (CA) is the definitive study for identifying the presence of CAD, but it is invasive, costly in bot dollar terms and patient morbidity, and provides no assessment of ventricular function. Cardiac magnetic resonance imaging (MRI) offers several powerful capabilities. It is the gold standard for quantitating ventricular function with 2D breath-hold cine acquisitions. Whole-heart coronary MRA centered on mid-diastole has also been demonstrated without contrast injection. However, both applications are limited by the challenges posed by cardiac and breathing motion. Cardiac function quantitation on 2D MRI suffers from breathing inconsistencies and consequent slice-to-slice spatial misregistration, particularly when patients, such as lung transplantation candidates, are unable to perform even a short breath-hold. Inconsistent breathing and selection of a fixed window at mid-diastole results in unacceptable scan times and reduces image quality in coronary studies since some coronary segments are not quiescent at that time. In this research we aim to: 1) develop self-gated free-breathing 4D cardiac MRI with novel self-gating, motion correction, and advanced image reconstruction methods; 2) optimize a 4D MRI protocol for cardiac function imaging and coronary artery imaging; and 3) implement the optimized methods in assessment of cardiac patients. Successful implementation of the proposed 4D cardiac MRI will not only be important for assessing CAD and ventricular function, but will be generalizable to conditions requiring similar capabilities, such as evaluation of valve disease, enhanced imaging of ischemic myocardium and assessment of vascular compliance. This will offer improved care for the vast population of patients with these conditions and financial benefits for the health car system.

描述（由申请人提供）：冠状动脉疾病和心室功能评估是心脏健康评估的关键要素。本研究的目的是 开发4D磁共振成像（MRI）技术，提供非侵入性和有效的心脏成像检查，包括评估冠状动脉疾病（CAD）以及左（LV）和右心室（RV）功能。 超声心动图（ECHO）广泛用于评估功能，但仅限于解剖结构的2D视图。考虑到右心室的位置、小梁和复杂解剖结构，其测量右心室尺寸的能力较差。CT血管造影术（CTA）提供了CAD和心室功能的非侵入性评估，但它涉及暴露于电离辐射和碘化造影剂的肾毒性风险。充分的CTA通常需要使用β受体阻滞剂，并通过给予硝酸甘油来改善，这两种药物都是某些患者的禁忌症。冠状动脉造影（CA）是确定CAD存在的决定性研究，但它是侵入性的，成本高，患者发病率高，并且不能评估心室功能。 心脏磁共振成像（MRI）提供了一些强大的功能。它是通过2D屏气电影采集定量心室功能的金标准。以心脏中段为中心的全心冠状动脉MRA也已被证明无需注射造影剂。然而，这两种应用都受到心脏和呼吸运动带来的挑战的限制。2D MRI上的心脏功能定量遭受呼吸不一致和随之而来的切片到切片空间配准不良，特别是当患者，例如肺移植候选人， 甚至连短暂的屏气都做不到不一致的呼吸和在中间时间点选择固定窗口会导致不可接受的扫描时间，并降低冠状动脉研究中的图像质量，因为此时某些冠状动脉节段不是静止的。 在本研究中，我们的目标是：1）开发具有新型自门控、运动校正和先进图像重建方法的自门控自由呼吸4D心脏MRI; 2）优化心脏功能成像和冠状动脉成像的4D MRI协议;和3）实施心脏病患者评估的优化方法。成功实施拟议的4D心脏MRI不仅对评估CAD和心室功能很重要，而且可推广到 需要类似功能的条件，例如瓣膜疾病的评价、缺血心肌的增强成像和血管顺应性的评估。这将为患有这些疾病的广大患者提供更好的护理，并为医疗保健系统带来经济利益。