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Biostatistics Core

生物统计学核心

基本信息

批准号：
8588552
负责人：
Matthew D Ringel
金额：
$ 14.08万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-25 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8588552
关键词：
Address Adherence Biological Biological Markers Biometry Biostatistics Core Cancer Center Clinical Clinical Research Clinical Trials Clinical Trials Design Collaborations Communication Complex Conduct Clinical Trials Data Data Analyses Data Display Data Quality Development Drug Formulations Ensure Experimental Designs Inferior Instruction Investigation Laboratories Lead Literature Maintenance Malignant neoplasm of thyroid Mentors Methodology Methods Observational Study Ohio Online Systems Pilot Projects Play Procedures Prospective Studies Quality Control Randomized Reporting Research Research Infrastructure Research Methodology Research Personnel Resources Retrospective Studies Role Sample Size Security Services Staging Statistical Methods Statistical Models Statistical Study Statistical sensitivity TNFRSF5 gene Testing Thinking Training Universities Validation Visual base biobank data integration data integrity data management design expectation experience meetings predictive modeling quality assurance repository research study success

项目摘要

The principal objective of the Biostatistics Core will be to provide project investigators a centralized resource for biostatistics expertise. Statistical issues will be addressed at all levels of investigation: from the design of clinical trials and laboratory experiments, to the maintenance of data quality; and from conclusions based on formal hypothesis testing, to important leads discovered by thorough data exploration. In support of this objective, the specific aims of the Core include: 1. Design: collaborate with project investigators in the design of clinical studies and laboratory experiments, formulation of unambiguous hypotheses and hypothesis testing strategies, and development and validation of predictive models. Analysis: provide support with: formal hypothesis tests in clinical and experimental data that ensure strong conclusions; statistical modeling and sensitivity analyses of prospective and retrospective studies; integrated analyses for discovery, training, and validation of predictive models; exploratory analyses that lead to further studies and experiments; and visual displays of data that clarify conclusions and uncover leads. Oversight and Infrastructure: provide oversight for the clinical trials, including design adherence and interim analyses, web based randomization, and data coordination services. Data Quality Assurance: manage data and coordinate services with the Integrated Clinicopathology and Biorepository Core to ensure high quality, security and investigator accessibility for all clinical and experimental data. Methods Research: Investigate new methodologies to directly address difficult data or design problems. Pilot projects: provide design and data analytic support for pilot projects. RELEVANCE (See instructions): The Biostatistics Core will provide critical support for planning and design of experiments and studies, statistical analyses and display of data, and data management and integrity. This support is designed to ensure that studies yield reliable conclusions, resources are efficiently used, and exploratory analyses uncover important leads.

生物统计核心的主要目标是为项目研究人员提供一个集中的资源