The Ohio State University and MD Anderson Cancer Center Thyroid Cancer SPORE

俄亥俄州立大学和 MD 安德森癌症中心甲状腺癌孢子

基本信息

  • 批准号:
    8548721
  • 负责人:
  • 金额:
    $ 215.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-09-25 至 2018-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION 3 OVERALL CRITIQUE 3 SPORE PROGRAM ORGANIZATION AND CAPABILITIES 6 SCIENTIFIC COLLABORATIONS 8 PROTECTION OF HUMAN SUBJECTS 10 VERTEBRATE ANIMALS 10 SCIENTIFIC REVIEW OFFICER'S NOTES 10 INDIVIDUAL PROJECTS AND CORES 11 PROJECT 1: Low-Penetrance Genes in the Predispositon to Papillary Thyroid Cancer 11 PROJECT 2: Preserving Salivary Gland Function after Radioiodine Therapy for Thyroid Cancer 15 PROJECT 3: Developing Combination Therapies for Medullary Thyroid Cancer 23 PROJECT 4: Development and Validation of Novel Circulating Medullary Thyroid Cancer Markers 29 CORE A/1: Integrated Clinicopathology and Biorespository Core 34 CORE B/2: Biostatistics Core 38 CORE C/3: Administrative Core 41 DEVELOPMENTAL RESEARCH PROGRAM 43 CAREER DEVELOPMENT PROGRAM 45 COMMITTEE BUDGET RECOMMENDATIONS 48 SPECIAL EMPHASIS PANEL ROSTER DESCRIPTION (provided by applicant): The primary goal of The Ohio State University / M.D. Anderson Thyroid Cancer SPORE is to improve the outcomes and lives of patients with thyroid cancer by identifying genetically "at-risk" individuals allowing for early diagnosis and prediction of tumor behavior, developing new approaches to minimize side effects of treatments, and developing better biomarkers and treatment options for progressive metastatic disease. Several factors support the importance of applying these efforts to thyroid cancer: 1) Thyroid cancer incidence is rising at the fastest rate of all malignancies in the United States and worldwide; it s now the 5th most common malignancy in women and 11th most common in men. 2) Thyroid cancer typically takes an indolent course, thus with the increasing incidence there is an ever enlarging population of individuals (-500,000) surviving long term, many of whom suffer from lifelong effects of initial therapy. 3) For patients with more aggressive forms of thyroid cancer, such as medullary cancer (MTC), there exist no curative therapies or biomarkers that accurately predict outcome from disease or response to particular treatments thereby limiting efforts to individualize therapeutic intensity. In order to achieve our goals, this SPORE application proposes to support a multi-institutional team of experienced investigators from two of the leading institutions in the field with a history of collaborative clinical trials. We have chosen t focus on critical areas of need for rapid translation into clinical practice for thyroid cancer patients with the following four Projects supported by outstanding Cores: 1) Low-penetrance genes in the predisposition to papillary thyroid carcinoma; 2) Biomarker discovery and personalized intervention of radioiodine induced salivary gland damage in thyroid cancer patients; 3) Developing combination therapies for Medullary Thyroid Cancer; and 4) Development and validation of novel circulating medullary thyroid cancer markers. Through these translational Projects, as well as Career Developmental and Developmental Research Programs, we aim to impact on critical areas of need in thyroid cancer clinical management for all forms of thyroid cancer. RELEVANCE: Thyroid cancer incidence is rising. Key issues in clinical care related to predictive testing for more aggressive disease, improving survivorship as many patients live for decades after their diagnosis, improving treatment for patients with aggressive forms of thyroid cancer and improving detection and monitoring of metastases This SPORE addresses these critical areas to improve the outcomes of patients with thyroid cancer.
描述3

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Matthew D Ringel其他文献

Matthew D Ringel的其他文献

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{{ truncateString('Matthew D Ringel', 18)}}的其他基金

RCAN 1.4 metastasis suppressor in thyroid cancer
RCAN 1.4 甲状腺癌转移抑制因子
  • 批准号:
    9973560
  • 财政年份:
    2020
  • 资助金额:
    $ 215.05万
  • 项目类别:
RCAN 1.4 metastasis suppressor in thyroid cancer
RCAN 1.4 甲状腺癌转移抑制因子
  • 批准号:
    10604328
  • 财政年份:
    2020
  • 资助金额:
    $ 215.05万
  • 项目类别:
RCAN 1.4 metastasis suppressor in thyroid cancer
RCAN 1.4 甲状腺癌转移抑制因子
  • 批准号:
    10400004
  • 财政年份:
    2020
  • 资助金额:
    $ 215.05万
  • 项目类别:
Role of p21-activated kinases in thyroid cancer
p21 激活激酶在甲状腺癌中的作用
  • 批准号:
    10377551
  • 财政年份:
    2018
  • 资助金额:
    $ 215.05万
  • 项目类别:
The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health
俄勒冈州立大学临床和转化科学中心:推进当今的发现以改善健康
  • 批准号:
    10414809
  • 财政年份:
    2018
  • 资助金额:
    $ 215.05万
  • 项目类别:
The Ohio State University and MD Anderson Cancer Center Thyroid Cancer SPORE
俄亥俄州立大学和 MD 安德森癌症中心甲状腺癌孢子
  • 批准号:
    8741949
  • 财政年份:
    2013
  • 资助金额:
    $ 215.05万
  • 项目类别:
Developing Combination Therapies for Medullary Thyroid Cancer
开发甲状腺髓样癌的联合疗法
  • 批准号:
    8588547
  • 财政年份:
    2013
  • 资助金额:
    $ 215.05万
  • 项目类别:
Integrated Clinicopathology and Biorespository Core
综合临床病理学和生物仓库核心
  • 批准号:
    8588551
  • 财政年份:
    2013
  • 资助金额:
    $ 215.05万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8588554
  • 财政年份:
    2013
  • 资助金额:
    $ 215.05万
  • 项目类别:
Biostatistics Core
生物统计学核心
  • 批准号:
    8588552
  • 财政年份:
    2013
  • 资助金额:
    $ 215.05万
  • 项目类别:

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