Resistance and Cardiorespiratory Time-matched Exercise Training in Youth: A Rando

青少年阻力和心肺时间匹配运动训练：A Rando

• 批准号: 8503821
• 负责人: SoJung Lee
• 金额: $ 109万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8503821
• 关键词: 17 year old; 19 year old; 25-hydroxyvitamin D; Abdomen; Adipose tissue; Adolescence; Adolescent; Adult; Aerobic; Aerobic Exercise; Age; American; Caloric Restriction; Carbohydrates; Cardiovascular Diseases; Cardiovascular system; Central obesity; Child; Childhood; Comorbidity; Control Groups; Development; Diet; Epidemic; Exercise; Fatty acid glycerol esters; Female Adolescents; Gender; Guidelines; Health; High Density Lipoproteins; High Prevalence; Insulin Resistance; Intervention; Lipids; Lipoproteins; Literature; Liver; Long-Term Effects; Low-Density Lipoproteins; Male Adolescents; Measures; Metabolic syndrome; Modality; Monitor; Muscle; National Health and Nutrition Examination Survey; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome Study; Overweight; Physical activity; Physiologic pulse; Plasma; Predisposing Factor; Premature aging syndrome; Proteins; Public Health; Randomized; Randomized Controlled Trials; Recruitment Activity; Regimen; Reporting; Resistance; Risk; Risk Factors; Skeletal Muscle; Sleep Apnea Syndromes; Staging; Testing; Thick; Time; Training; United States Dept. of Health and Human Services; Very low density lipoprotein; Visceral; Weight Gain; Work; Youth; abdominal fat; adiponectin; aged; arterial stiffness; boys; effective intervention; energy balance; girls; glucose tolerance; glycemic control; group intervention; improved; in vivo; insulin sensitivity; intima media; intrahepatic; muscle form; obesity in children; prevent; public health relevance; sedentary; treatment strategy; weight maintenance

DESCRIPTION (provided by applicant): The current epidemic rate of childhood obesity is a leading health concern as overweight/obese youth may suffer from comorbid conditions, once considered exclusive to adults. It has been suggested that physical inactivity is a major determinant of obesity and obesity-related health risk in children and adolescents. Recent studies in adults report that the combination of aerobic and resistance exercise is a better strategy than aerobic or resistance exercise alone for reducing risk factors for type 2 diabetes. Currently, the most effective exercise modality for concurrent reductions of [adiposity], in particular abdominal fat, and risk factors for type 2 diabetes and cardiovascular disease (CVD) is unknown in adolescents. Therefore, we will employ, for the first time, a randomized controlled trial to examine the effects of a long-term aerobic exercise, resistance exercise, and a combination of both exercise regimens on: 1) in vivo insulin sensitivity, glucose tolerance and risk for type 2 diabetes; 2) total adiposity, skeletal muscle mass, visceral adiposity and ectopic fat in the liver and skeletal muscle; 3) traditional and non-traditional risk factors/markers for CD in overweight boys and girls. We will recruit [168] sedentary overweight (BMI >85th percentile) adolescent boys and girls aged 12-[17] years old and randomly assign them to one of four 6-month intervention groups (n = [42] each group): 1) aerobic exercise (180 min/week), 2) resistance exercise (180 min/week), 3) [combined] aerobic and resistance exercise (180 min/week) or 4) non-exercising control group. A weight maintenance diet (55-60% carbohydrate, 15-20% protein, and 25-30% fat) will be prescribed and monitored for all groups, so that any changes in energy balance will be induced by exercise intervention alone (e.g., no calorie restriction). We believe that this proposed application will have a significant implication that is directly relevant for one in three American adolescents who are at increased risk of developing obesity-related co-morbidities.

描述（由申请人提供）：目前儿童肥胖症的流行率是一个主要的健康问题，因为超重/肥胖青少年可能患有共病，曾经被认为是成年人独有的。研究表明，缺乏身体活动是儿童和青少年肥胖和肥胖相关健康风险的主要决定因素。最近的成人研究报告说，有氧运动和阻力运动的结合是一个更好的策略比有氧运动或阻力运动单独减少2型糖尿病的危险因素。目前，在青少年中，同时减少[肥胖]，特别是腹部脂肪，以及2型糖尿病和心血管疾病（CVD）风险因素的最有效的运动方式尚不清楚。因此，我们将首次采用随机对照试验来检查长期有氧运动、抗阻运动以及两种运动方案的组合对以下方面的影响：1）体内胰岛素敏感性、葡萄糖耐量和2型糖尿病风险; 2）总肥胖、骨骼肌质量、内脏脂肪和肝脏和骨骼肌中的异位脂肪; 3）超重男孩和女孩中CD的传统和非传统危险因素/标志物。我们将招募[168]久坐超重（BMI >第85百分位数）12-[17]岁的青少年男孩和女孩，并将他们随机分配到四个6个月干预组之一（每组n = [42]）：1）有氧运动（180分钟/周），2）抗阻运动（180分钟/周），3）有氧运动和抗阻运动（180分钟/周）或4）非运动对照组。将为所有组规定并监测体重维持饮食（55-60%碳水化合物、15-20%蛋白质和25-30%脂肪），以便仅通过运动干预诱导能量平衡的任何变化（例如，无卡路里限制）。我们认为，这项拟议的申请将产生重大影响， 与三分之一的美国青少年直接相关，他们患肥胖相关共病的风险增加。