2013 Elastin, Elastic Fibers & Microfibrils Gordon Research Conference & Gordon R

描述（由申请人提供）：我们提议组织并支持2013年戈登研究研讨会（GRS）和戈登研究会议（GRC）关于弹性蛋白，弹性纤维和微纤维将于2013年7月20日至21日（GRS）和7月21日至26日（GRC）在缅因州比德福德的新英格兰大学举行。这个两年一次的会议代表了关于弹性纤维和微纤维系统的知识交流和研究传播的主要国际论坛，弹性纤维和微纤维系统是脉管系统、肺、骨骼、肌肉、皮肤和其他组织的关键组成部分。会议将为科学界和非学术利益相关者提供弹性纤维系统的新的基本机制，以及对源于弹性纤维/微纤维系统功能失调的获得性和遗传性结缔组织疾病的新的和改进的诊断和治疗策略。以弹性纤维系统及其组分为重点的研究高度适用于NHLBI和NIAMS的疾病靶点。弹性纤维成分和微原纤维的异常沉积和转换是获得性疾病的发病机制的核心，包括动脉粥样硬化、动脉瘤、慢性阻塞性肺疾病、全身和肺动脉高压的血管重塑以及皮肤老化机制。会议讨论的遗传疾病包括但不限于马凡氏综合征、比尔综合征、威廉姆斯-伯伦综合征、瓣上主动脉瓣狭窄、城市-里夫金-戴维斯综合征、洛伊斯-迪茨综合征、肢端畸形发育不良、皮肤松弛、皮肤僵硬综合征和影响心血管、肺和肌肉骨骼系统的系统性硬化症。这些后天和遗传性疾病影响着数百万美国人和全世界数亿人。2013年GRS/GRC联合会议的具体目标是：1)聚集不同（性别，国籍，职业阶段，少数民族，工作环境）的研究人员，来自患者权益团体的代表和其他来自多学科的非学术利益相关者，集中，全面的会议，展示弹性纤维相关研究的最新发现，创新理念和前沿研究。2)促进研究人员之间的国际合作机会，团队和网络，这将激励和促进多学科和转化方法来研究获得性和遗传性疾病

DESCRIPTION (provided by applicant): We propose to organize and support the 2013 Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) on Elastin, Elastic Fibers & Microfibrils to be held in conjunction from July 20th - 21st (GRS) and July 21st - 26th (GRC) 2013 at the University of New England in Biddeford, Maine. This biennial conference represents the leading international forum for knowledge exchange and dissemination of research on the elastic fiber and microfibril system, which are critical components of the vasculature, lung, bone, muscle skin and other tissues. The conference will provide the scientific community and non-academic stakeholders with new basic mechanisms of elastic fiber systems, as well as with new and improved diagnostic and therapeutic strategies for acquired and genetic connective tissue disorders originating from derailed functions of the elastic fiber/microfibril system. Research focusing on elastic fiber systems and its components is highly applicable to the disease targets of the NHLBI and NIAMS. Abnormal deposition and turnover of elastic fiber components and microfibrils is central to the pathogenesis of acquired diseases including atherosclerosis, aneurysms, chronic obstructive pulmonary disease, vascular remodeling in systemic and pulmonary hypertension, and skin aging mechanisms. Genetic disorders discussed in the conference include, but are not limited to Marfan syndrome, Beal's syndrome, Williams-Beuren syndrome, supravalvular aortic stenosis, Urban-Rifkin-Davis syndrome, Loeys-Dietz syndrome, acromelic dysplasias, cutis laxa, stiff skin syndrome and systemic sclerosis affecting the cardiovascular, pulmonary and musculoskeletal systems. These combined acquired and genetic diseases affect millions of Americans and hundreds of millions worldwide. The specific aims of the combined 2013 GRS/GRC conference are: 1) To gather diverse (gender, nationality, career stage, minorities, working environment) investigators, representatives from patient advocate groups and other non-academic stakeholders from multiple disciplines for a focused, comprehensive conference presenting the latest findings, innovative ideas and cutting edge research in elastic fiber related research. 2) To foster international collaborative opportunities, teams and networks between investigators which will inspire and facilitate multidisciplinary and translational approaches to investigating acquired and genetic elastic fiber and microfibril diseases. 3) To improve health by stimulating knowledge transfer and by giving the opportunity to basic scientists and clinicians to exchange with representatives of biotech and pharmaceutical industries. 4) To encourage and mentor new trainees through the new Gordon Research Seminar toward career success in elastic fiber-related research and support them through travel and excellence awards.