2013 Elastin, Elastic Fibers & Microfibrils Gordon Research Conference & Gordon R

2013 弹性蛋白、弹性纤维

• 批准号: 8587282
• 负责人: ZSOLT URBAN
• 金额: $ 1.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8587282
• 关键词: Advocate; Affect; American; Aneurysm; Atherosclerosis; Award; Blood Vessels; Cardiovascular system; Chronic Obstructive Airway Disease; Communities; Connective Tissue; Connective Tissue Diseases; Cutis Laxa; Deposition; Diagnostic; Discipline; Disease; Drug Industry; Dysplasia; Elastic Fiber; Elastin; Fostering; Gender; Genetic; Health; Hereditary Disease; Hypertension; Inborn Genetic Diseases; Inherited; International; Knowledge; Loeys-Dietz Syndrome; Lung; Maine; Marfan Syndrome; Mentors; Microfibrils; Minority; Muscle; Musculoskeletal; Musculoskeletal System; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nationalities; New England; Pathogenesis; Patient Representative; Pulmonary Emphysema; Pulmonary Hypertension; Research; Research Personnel; Research Support; Scientist; Skin; Skin Aging; Staging; Stroke; Supravalvular aortic stenosis; Syndrome; System; Systemic Scleroderma; Therapeutic; Tissues; Travel; Universities; Vascular remodeling; Williams Syndrome; Workplace; bone; career; dissemination research; improved; innovation; interdisciplinary approach; public health relevance; success; symposium; translational approach; ultraviolet damage

DESCRIPTION (provided by applicant): We propose to organize and support the 2013 Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) on Elastin, Elastic Fibers & Microfibrils to be held in conjunction from July 20th - 21st (GRS) and July 21st - 26th (GRC) 2013 at the University of New England in Biddeford, Maine. This biennial conference represents the leading international forum for knowledge exchange and dissemination of research on the elastic fiber and microfibril system, which are critical components of the vasculature, lung, bone, muscle skin and other tissues. The conference will provide the scientific community and non-academic stakeholders with new basic mechanisms of elastic fiber systems, as well as with new and improved diagnostic and therapeutic strategies for acquired and genetic connective tissue disorders originating from derailed functions of the elastic fiber/microfibril system. Research focusing on elastic fiber systems and its components is highly applicable to the disease targets of the NHLBI and NIAMS. Abnormal deposition and turnover of elastic fiber components and microfibrils is central to the pathogenesis of acquired diseases including atherosclerosis, aneurysms, chronic obstructive pulmonary disease, vascular remodeling in systemic and pulmonary hypertension, and skin aging mechanisms. Genetic disorders discussed in the conference include, but are not limited to Marfan syndrome, Beal's syndrome, Williams-Beuren syndrome, supravalvular aortic stenosis, Urban-Rifkin-Davis syndrome, Loeys-Dietz syndrome, acromelic dysplasias, cutis laxa, stiff skin syndrome and systemic sclerosis affecting the cardiovascular, pulmonary and musculoskeletal systems. These combined acquired and genetic diseases affect millions of Americans and hundreds of millions worldwide. The specific aims of the combined 2013 GRS/GRC conference are: 1) To gather diverse (gender, nationality, career stage, minorities, working environment) investigators, representatives from patient advocate groups and other non-academic stakeholders from multiple disciplines for a focused, comprehensive conference presenting the latest findings, innovative ideas and cutting edge research in elastic fiber related research. 2) To foster international collaborative opportunities, teams and networks between investigators which will inspire and facilitate multidisciplinary and translational approaches to investigating acquired and genetic elastic fiber and microfibril diseases. 3) To improve health by stimulating knowledge transfer and by giving the opportunity to basic scientists and clinicians to exchange with representatives of biotech and pharmaceutical industries. 4) To encourage and mentor new trainees through the new Gordon Research Seminar toward career success in elastic fiber-related research and support them through travel and excellence awards.

描述（由申请人提供）：我们建议组织和支持2013年戈登研究研讨会（GRS）和戈登研究会议（GRC）的弹性蛋白，弹性纤维和微纤维将于2013年7月20日至21日（GRS）和7月21日至26日（GRC）在新英格兰比德福德，缅因州的大学举行。这个两年一次的会议代表了关于弹性纤维和微纤维系统研究的知识交流和传播的领先国际论坛，这些系统是血管系统，肺，骨骼，肌肉皮肤和其他组织的关键组成部分。该会议将为科学界和非学术利益相关者提供弹性纤维系统的新的基本机制，以及新的和改进的诊断和治疗策略，用于源于弹性纤维/微纤维系统脱轨功能的获得性和遗传性结缔组织疾病。侧重于弹性纤维系统及其组分的研究非常适用于NHLBI和NIAMS的疾病目标。弹性纤维组分和微纤维的异常沉积和周转是获得性疾病（包括动脉粥样硬化、动脉瘤、慢性阻塞性肺病、全身性和肺动脉高压中的血管重塑以及皮肤老化机制）的发病机制的核心。会议中讨论的遗传性疾病包括但不限于马凡氏综合征、比尔氏综合征、威廉斯-博伦综合征、瓣上主动脉狭窄、乌尔班-里夫金-戴维斯综合征、洛伊-迪茨综合征、肢端发育不良、皮肤拉克萨、皮肤僵硬综合征和影响心血管、肺和肌肉骨骼系统的系统性硬化症。这些合并获得性和遗传性疾病影响数百万美国人和全世界数亿人。2013年GRS/GRC联合会议的具体目标是：1）聚集不同（性别，国籍，职业阶段，少数民族，工作环境）的研究人员，来自患者倡导团体的代表和来自多个学科的其他非学术利益相关者，举办一次集中，全面的会议，介绍弹性纤维相关研究的最新发现，创新思想和前沿研究。2)促进研究者之间的国际合作机会、团队和网络，这将激励和促进多学科和转化方法，以调查获得的和 遗传性弹性纤维和微纤维疾病。3)通过促进知识转让和为基础科学家和临床医生提供与生物技术和制药行业代表交流的机会来改善健康。4)通过新的戈登研究研讨会鼓励和指导新学员在弹性纤维相关研究中取得职业成功，并通过旅行和卓越奖支持他们。