Aspen Lung Conference: The Lung Microbiome: A New Frontier in Pulmonary Medicine

阿斯彭肺会议：肺微生物组：肺医学的新领域

• 批准号: 8528307
• 负责人: RICHARD J MARTIN
• 金额: $ 1万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528307
• 关键词: Address; Bacterial Translocation; Basic Science; Birth; Blood Circulation; Breathing; Clinical Sciences; Diet; Disease; Environment; Genetic; Health; Immune system; International; Knowledge; Lead; Lung; Mothers; Mucous Membrane; Organ; Physicians; Population; Pulmonology; Research; Research Personnel; Respiration Disorders; Scientist; Site; Skin; Sterility; Surface; Testing; Translational Research; Vagina; frontier; interest; meetings; microbial; microbiome; particle; symposium

DESCRIPTION (provided by applicant): The theme of the 56th Annual Thomas L. Petty Lung Conference is "The Lung Microbiome: A New Frontier in Pulmonary Medicine." Emphasizing the integration of basic, translational and clinical sciences, the meeting will focus upon the lung microbiome and its interactions with the environment, genetics and diet in healthy states and disease. As an organ that is constantly exposed to the environment as well as the systemic circulation, the lung encounters inhaled particles that are certainly not sterile and an immune system that has to differentiate between self and non-self. Whether the lung has unique microbial populations that occupy specific niches is still a subject for debate. The 2013 Aspen Lung Conference will examine and discuss microbiota from well- studied mucosal surfaces (gut, skin) and the likely interplay with lung mucosa. Questions that remain to be answered and that will be addressed in this conference include: Is there crosstalk between the lung and the gut? Is there bacterial translocation from gut to lung? Is the lung microbiome established at birth? Does it reflect the mother's vaginal microbiome or is it a reflection of the microbiome in the upper airways? Are the interactions with the host primarily through the innate or adaptive immune systems? The overall objectives of this conference are: 1) To stimulate conversations and cross-pollination between pulmonary research scientists and physicians and basic scientists whose main focus is the identification and testing of microbiomes in various anatomical sites 2) To initiate a dialogue between microbiologists and researchers interested in pulmonary pathobiology. 3) To educate pulmonary scientists about the potential cross-talk between the microbiomes of the lung and various extrapulmonary sites 4) Provide an international forum for leading clinicians and researchers to exchange ideas relating to lung microbiome and its relationship to microbiomes at other anatomical sites 5) Fill a knowledge gap in the understanding of whether there is a unique lung microbiome 6) Stimulate new perspectives and further research in pulmonary microbiota in health and disease Determine if and how the alteration in the lung microbiome leads to or alters respiratory disorders 7) To create an environment that will lead to sustained interest among trainees

描述（由申请人提供）：第56届年度托马斯L。Petty肺部会议是“肺部微生物组：肺部医学的新前沿。“强调基础，转化和临床科学的整合，会议将重点关注肺部微生物组及其与健康状态和疾病中的环境，遗传学和饮食的相互作用。作为一个不断暴露于环境和体循环的器官，肺会遇到吸入的颗粒，这些颗粒肯定不是无菌的，免疫系统必须区分自我和非自我。肺是否具有占据特定生态位的独特微生物种群仍然是一个争论的主题。2013年白杨肺部会议将检查和讨论来自经过充分研究的粘膜表面（肠道、皮肤）的微生物群以及与肺粘膜可能的相互作用。仍有待回答的问题，并将在本次会议上解决包括：肺和肠道之间是否存在串扰？是否有细菌从肠道转移到肺部？肺部微生物组是在出生时建立的吗？它反映了母亲的阴道微生物组还是上呼吸道微生物组的反映？与宿主的相互作用主要是通过先天免疫系统还是适应性免疫系统？本次会议的总体目标是：1）促进肺部研究科学家和医生以及基础科学家之间的对话和交叉授粉，其主要重点是识别和测试各种解剖部位的微生物组2）启动微生物学家和对肺部病理学感兴趣的研究人员之间的对话。 3)教育肺部科学家关于肺部微生物组与各种肺外部位之间的潜在串扰4）为领先的临床医生和研究人员提供一个国际论坛，以交流与肺部微生物组及其与其他解剖部位微生物组的关系有关的想法5）填补了解是否存在独特的肺部微生物组的知识空白6）激发健康和疾病中肺部微生物群的新视角和进一步研究确定肺部微生物群的改变是否以及如何导致或改变呼吸系统疾病7）创造一个能引起学员持续兴趣的环境