Aspen Lung Conference: The Lung Microbiome: A New Frontier in Pulmonary Medicine

描述(申请人提供)：第56届托马斯·L·佩蒂肺部年会的主题是“肺微生物组：肺部医学的新前沿”。会议强调基础、翻译和临床科学的整合，将重点讨论肺微生物组及其与健康状态和疾病的环境、遗传和饮食的相互作用。作为一个不断暴露在环境和全身循环中的器官，肺遇到了肯定不是无菌的吸入颗粒，以及必须区分自我和非我的免疫系统。肺部是否有独特的微生物种群占据着特定的生态位，这仍然是一个争论的话题。2013年的阿斯彭肺脏会议将研究和讨论来自研究良好的粘膜表面(肠道、皮肤)的微生物区系，以及可能与肺粘膜的相互作用。有待回答的问题和将在这次会议上解决的问题包括：肺和肠道之间是否存在交叉？有没有细菌从肠道移位到肺部？肺部微生物群是在出生时就建立起来的吗？它是反映了母亲的阴道微生物群，还是反映了上呼吸道的微生物群？与宿主的相互作用主要是通过先天免疫系统还是获得性免疫系统？这次会议的总体目标是：1)促进肺部研究科学家与内科医生和基础科学家之间的对话和交叉授粉，他们的主要重点是鉴定和测试不同解剖部位的微生物群2)发起微生物学家和对肺部病理生物学感兴趣的研究人员之间的对话。3)教育肺部科学家了解肺和肺外各部位微生物群之间的潜在相互作用4)为临床医生和研究人员提供一个国际论坛，交流有关肺微生物群及其与其他解剖部位微生物群的关系5)填补了解是否存在独特的肺微生物群的知识空白6)激发对健康和疾病中肺微生物区系的新视角和进一步研究，确定肺微生物群的改变是否和如何导致或如何导致或改变呼吸系统疾病7)创造一个环境，使受训者持续感兴趣

DESCRIPTION (provided by applicant): The theme of the 56th Annual Thomas L. Petty Lung Conference is "The Lung Microbiome: A New Frontier in Pulmonary Medicine." Emphasizing the integration of basic, translational and clinical sciences, the meeting will focus upon the lung microbiome and its interactions with the environment, genetics and diet in healthy states and disease. As an organ that is constantly exposed to the environment as well as the systemic circulation, the lung encounters inhaled particles that are certainly not sterile and an immune system that has to differentiate between self and non-self. Whether the lung has unique microbial populations that occupy specific niches is still a subject for debate. The 2013 Aspen Lung Conference will examine and discuss microbiota from well- studied mucosal surfaces (gut, skin) and the likely interplay with lung mucosa. Questions that remain to be answered and that will be addressed in this conference include: Is there crosstalk between the lung and the gut? Is there bacterial translocation from gut to lung? Is the lung microbiome established at birth? Does it reflect the mother's vaginal microbiome or is it a reflection of the microbiome in the upper airways? Are the interactions with the host primarily through the innate or adaptive immune systems? The overall objectives of this conference are: 1) To stimulate conversations and cross-pollination between pulmonary research scientists and physicians and basic scientists whose main focus is the identification and testing of microbiomes in various anatomical sites 2) To initiate a dialogue between microbiologists and researchers interested in pulmonary pathobiology. 3) To educate pulmonary scientists about the potential cross-talk between the microbiomes of the lung and various extrapulmonary sites 4) Provide an international forum for leading clinicians and researchers to exchange ideas relating to lung microbiome and its relationship to microbiomes at other anatomical sites 5) Fill a knowledge gap in the understanding of whether there is a unique lung microbiome 6) Stimulate new perspectives and further research in pulmonary microbiota in health and disease Determine if and how the alteration in the lung microbiome leads to or alters respiratory disorders 7) To create an environment that will lead to sustained interest among trainees