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Host iNOS dictates gut dysbiosis, bacterial translocation and tissue insulin resistance in murine and human obesity

Host iNOS dictates gut dysbiosis, bacterial translocation and tissue insulin resistance in murine and human obesity
宿主 iNOS 决定小鼠和人类肥胖症的肠道菌群失调、细菌易位和组织胰岛素抵抗
批准号:
453491
负责人:
Marette Andr
金额:
$59.35万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2021
资助国家:
加拿大
项目状态:
未结题
起止时间:
2021-09-01 至 2026-09-01

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中文摘要
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英文摘要
Changes in the type of gut microbes (known of the microbiota) can promote obesity and diabetes. We showed that type 2 diabetes alters bacteria in adipose tissues and the liver in obese persons and we now propose that alterations in the immune system and h
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Nutrient sensing mechanisms underlying the metabolic effects of dietary proteins in obesity and type 2 diabetes
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    479374
  • 项目类别:
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  • 资助金额:
    $54.62万
  • 财政年份:
    2023
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Role of altered production of branched-chain hydroxy acids (BCHA) in the pathogenesis of type 2 diabetes (T2D) and fatty liver disease and its prevention by BCHA-supplemented yogurt
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    469858
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    $54.89万
  • 财政年份:
    2022
  • 负责人:
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Microbiome and liver mechanisms underlying the impact of dietary proteins on obesity and insulin resistance
  • 批准号:
    456675
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2021
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Dissecting host-microbiome modifiers of type 2 diabetes risk
  • 批准号:
    411921
  • 项目类别:
    Operating Grants
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    $145.7万
  • 财政年份:
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  • 负责人:
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  • 依托单位:
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