Independent Scientist: ARFI and RWI Ultrasound for Improved Atherosclerosis Imagi

独立科学家：ARFI 和 RWI 超声可改善动脉粥样硬化 Imagi

• 批准号: 8499407
• 负责人: Caterina M Gallippi
• 金额: $ 10.18万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8499407
• 关键词: Acoustics; Address; Adult; Arterial Fatty Streak; Arteries; Atherosclerosis; Award; Blood flow; Budgets; Calcium; Carotid Arteries; Carotid Endarterectomy; Cause of Death; Clinical; Clinical Trials Design; Collagen; Data; Data Analyses; Deposition; Detection; Diagnosis; Diagnostic Imaging; Discrimination; Disease; Dissection; Elastin; Electrical Engineering; Ethics; Family suidae; Feasibility Studies; Fibrin; Funding; Gold; Heart Diseases; Human; Image; Imaging Techniques; Imaging technology; Immunohistochemistry; Incidence; Intervention; Laboratories; Left; Lipids; Malignant Neoplasms; Mechanics; Methods; National Heart, Lung, and Blood Institute; Obstruction; Patients; Peripheral; Physics; Predictive Value; Property; Radiation; Research; Research Proposals; Risk; Risk Assessment; Rupture; Schedule; Scientist; Sensitivity and Specificity; Stroke; Structure; Technology; Testing; Tissues; Training; Translating; Translations; Ultrasonography; United States; Validation; Work; arterial remodeling; base; disability; electric impedance; iliac artery; imaging modality; improved; in vivo; novel; prevent; public health relevance; volunteer

DESCRIPTION (provided by applicant): While stroke remains the third leading cause of death behind heart disease and cancer and the primary cause of serious, long-term disability in the United States, decreasing incidence has been attributed to interventions including revascularization and statin therapy. However, administration of proper treatment is limited by inadequacies in modern diagnostic imaging technologies. These technologies are effective for detecting occlusive plaques associated with pronounced lumenal narrowing (occlusion) and/or blood flow obstruction, but their focus on lumenal features inhibits detection of nonocclusive plaques contained in arterial walls. Furthermore, their ability to predict plaque risk for causing cerebrovascular accident (CVA) is not established. There is a clear unmet need for a validated atherosclerosis imaging modality that can improve plaque detection and predict rupture risk. To address this need, our laboratory is developing novel acoustic radiation force-based images methods, which interrogate tissue composition and structure - features that indicate rupture risk. Our on-going R01 research involves developing one acoustic radiation force-based imaging methods, Acoustic Radiation Force Impulse (ARFI) ultrasound, for atherosclerosis diagnosis. We now propose to explore a new acoustic radiation force-based method, Relfected Wave Imaging (RWI), to improve ARFI's delineation of plaque composition and structure. We hypothesize that in vivo, transcutaneous ARFI and RWI ultrasound are capable of detecting occlusive and nonocclusive plaques in peripheral arteries and of assessing plaque composition and structure. The on-going R01 research pursues three specific aims: 1) Define the sensitivity and specificity of ARFI ultrasound for detecting plaques in familial hypercholesterolemic (FH) pigs, 2) Establish that ARFI imaging delineates plaque composition and structure in FH pigs, and 3) Establish that ARFI imaging delineates plaques and their composition and structure in humans. We now propose a new aim to develop RWI technology: 4) Exploit the reflections of acoustic radiation force-induced longitudinal and transverse waves to improve discrimination of plaque composition and structure in Reflected Wave Imaging (RWI). RWI alone and RWI as an adjunct to ARFI will be compared to ARFI alone for improvements in imaging sensitivity and specificity. The PI is trained in electrical engineering and ultrasound physics, but she proposes additional training in the physics of mechanical wave propagation in tissue to pursue aim #4 to her fullest capacity. In addition, the PI proposes training in clinical trials design, execution, and management as well as ethical conduct of research.

描述（由申请人提供）：虽然中风仍然是美国仅次于心脏病和癌症的第三大死亡原因，也是严重长期残疾的主要原因，但发病率下降归因于包括血运重建和他汀类药物治疗在内的干预措施。然而，适当治疗的管理受到现代诊断成像技术不足的限制。这些技术可有效检测与明显管腔狭窄（闭塞）和/或血流阻塞相关的闭塞性斑块，但其对管腔特征的关注抑制了对动脉壁中包含的非闭塞性斑块的检测。此外，他们的能力，以预测斑块的风险，导致脑血管意外（CVA）还没有建立。对于可以改善斑块检测和预测破裂风险的经验证的动脉粥样硬化成像模式，存在明显未满足的需求。为了满足这一需求，我们的实验室正在开发新的基于声辐射力的图像方法，该方法询问组织成分和结构-指示破裂风险的特征。我们正在进行的R 01研究涉及开发一种基于声辐射力的成像方法，声辐射力脉冲（ARFI）超声，用于动脉粥样硬化诊断。我们现在建议探索一种新的基于声辐射力的方法，反射波成像（RWI），以改善ARFI对斑块组成和结构的描绘。我们假设，在体内，经皮ARFI和RWI超声能够检测闭塞性和非闭塞性斑块在外周动脉和评估斑块的组成和结构。正在进行的R 01研究追求三个特定目标：1）确定ARFI超声检测家族性高胆固醇血症（FH）猪斑块的灵敏度和特异性，2）确定ARFI成像描绘FH猪斑块组成和结构，3）确定ARFI成像描绘人类斑块及其组成和结构。我们现在提出了一个新的目标，发展RWI技术：4）利用声辐射力引起的纵向和横向波的反射，以提高反射波成像（RWI）的斑块成分和结构的区分。将单独RWI和RWI作为ARFI的辅助治疗与单独ARFI进行比较，以改善成像灵敏度和特异性。PI接受过电气工程和超声物理学的培训，但她建议在组织中机械波传播的物理学方面进行额外培训，以充分发挥她的能力来实现目标4。此外，PI建议在临床试验设计、执行和管理以及研究伦理行为方面进行培训。