Neuronal Pathways for Social Rejection: fMRI Studies

社交拒绝的神经元通路：功能磁共振成像研究

• 批准号: 8461696
• 负责人: David Tai Hsu
• 金额: $ 12.44万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-21 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8461696
• 关键词: American Psychiatric Association; Amygdaloid structure; Animal Experimentation; Anterior; Anxiety; Anxiety Disorders; Atypical depressive disorder; Behavior; Behavioral; Biological; Brain; Cognitive; DSM-IV; Data; Diagnosis; Emotional; Emotions; Family member; Feedback; Functional Magnetic Resonance Imaging; Goals; Human; Individual; Laboratories; Lead; Macaca; Magnetic Resonance Imaging; Major Depressive Disorder; Maps; Measures; Mentored Research Scientist Development Award; Mentors; Modeling; Monkeys; Mood Disorders; Neurons; Nucleus Accumbens; Pathway interactions; Patients; Preventive; Price; Process; Psychologist; Rattus; Research; Research Design; Research Methodology; Research Personnel; Rest; Rewards; Risk-Taking; Signal Transduction; Stimulus; Stress; Structure; Substance abuse problem; Testing; Thalamic structure; Training; Translational Research; Violence; base; biological adaptation to stress; blood oxygenation level dependent response; cingulate cortex; depressive symptoms; design; disorder risk; impression; improved; innovation; interest; midbrain central gray substance; neuroimaging; peer; positive emotional state; psychologic; public health relevance; research study; response; self esteem; social; virtual

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development Award will support the candidate in transitioning into an independent investigator in translational research with a focus on mood disorders. With a background in animal research, the candidate proposes training in human functional magnetic resonance imaging (fMRI) to investigate brain activity associated with social rejection and acceptance. Social rejection (an explicit declaration that an individual is not liked) has powerful effects on emotion and behavior including lowered self- esteem, major depression, risk-taking behavior, substance abuse, and violence. A few fMRI studies have found increased activity in the anterior cingulate cortex using different paradigms for social rejection. The first aim of the project is to test experimental manipulations for social rejection, explore its parameters, and adapt a stimulus presentation for use in fMRI experiments. The second aim is to use fMRI to examine neuronal pathways involved in social rejection. Based on anatomical pathways found in rats and monkeys, it is hypothesized that in addition to the anterior cingulate cortex, activation will be found in the periaqueductal gray, thalamus, amygdala, nucleus accumbens, and subgenual cortex. These structures are known to be involved in stress responses and major depression, as well as responding to rewards. An exploratory aim will assess behavioral responses to social rejection in patients with Major Depressive Disorder (MDD) without fMRI. Once the behavioral responses are studied, my long-term goal is to examine abnormal neuronal responses to social rejection in MDD with neuroimaging. Atypical depression, for example, is uniquely characterized by intense social rejection sensitivity. Identifying a unique biological profile for a depressive subtype may improve its definition, diagnosis, and treatment.

描述(由申请者提供)：这个指导性研究科学家发展奖将支持候选人转变为专注于情绪障碍的翻译研究的独立调查员。有动物研究背景的候选人建议接受人类功能磁共振成像(FMRI)方面的培训，以调查与社会拒绝和接受相关的大脑活动。社交排斥(一个人不受欢迎的明确声明)对情绪和行为有强大的影响，包括自尊降低、严重抑郁、冒险行为、滥用药物和暴力。一些功能磁共振研究发现，使用不同的社交排斥范式，前扣带回皮质的活动增加。该项目的第一个目标是测试社会拒绝的实验操作，探索其参数，并将刺激呈现调整为用于功能磁共振实验。第二个目标是使用功能磁共振成像来检查与社会排斥有关的神经元通路。根据在大鼠和猴子身上发现的解剖通路，假设除扣带回前皮质外，中脑导水管周围灰质、丘脑、杏仁核、伏隔核和膝下皮质也有激活。众所周知，这些结构与压力反应、严重抑郁以及对奖励的反应有关。一个探索性的目的是评估没有功能磁共振成像的严重抑郁障碍(MDD)患者对社会排斥的行为反应。一旦研究了行为反应，我的长期目标是用神经成像检查MDD患者对社会排斥反应的异常神经元反应。例如，非典型抑郁症的独特特征是强烈的社会排斥敏感性。确定抑郁症亚型的独特生物学特征可能会改善其定义、诊断和治疗。

项目成果

Common neural responses to romantic rejection and acceptance in healthy adults.

• DOI: 10.1080/17470919.2020.1801502
• 发表时间: 2020-10
• 期刊: Social neuroscience
• 影响因子: 2
• 作者: Hsu DT;Sankar A;Malik MA;Langenecker SA;Mickey BJ;Love TM
• 通讯作者: Love TM

Abnormal emotional and neural responses to romantic rejection and acceptance in depressed women.

抑郁女性对浪漫拒绝和接受的异常情绪和神经反应。

• DOI: 10.1016/j.jad.2018.02.083
• 发表时间: 2018
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Yttredahl,AshleyA;McRobert,Erin;Sheler,Benjamin;Mickey,BrianJ;Love,TiffanyM;Langenecker,ScottA;Zubieta,Jon-Kar;Hsu,DavidT
• 通讯作者: Hsu,DavidT