Abnormal emotional and neural responses to romantic rejection and acceptance in depressed women.
Abnormal emotional and neural responses to romantic rejection and acceptance in depressed women.
复制标题
抑郁女性对浪漫拒绝和接受的异常情绪和神经反应。
DOI：
10.1016/j.jad.2018.02.083
复制
发表时间：
2018
影响因子：
6.6
通讯作者：
Hsu,DavidT
中科院分区：
文献类型：
--
作者：
Yttredahl,AshleyA;McRobert,Erin;Sheler,Benjamin;Mickey,BrianJ;Love,TiffanyM;Langenecker,ScottA;Zubieta,Jon-Kar;Hsu,DavidT
前言对社会环境的适应性反应是预测抑郁症病程的关键因素。社交拒绝事件可能会加剧抑郁症状，而社交接受事件可以改善抑郁症状。神经反应拒绝和接受在MDD.MethodsWe使用功能磁共振成像（fMRI）来衡量神经反应浪漫的拒绝和接受诊断为目前的MDD（n = 19）和一组匹配的健康对照（HC）（n = 19）的妇女。在功能磁共振成像，参与者收到拒绝，接受，和中立的反馈，从自我选择的潜在的浪漫partners.ResultsIn女性抑郁症，但不HC，拒绝显着增加活动在右前额叶相对于中立的反馈。更大的激活在排斥反应中被发现在背侧前扣带皮层在MDD相比，HC。MDD的女性比HC更强烈的情绪反应，拒绝和接受。此外，左，右核脑桥（NAcc）的活动介导的特质奖励反应和增加评级的感觉“快乐和接受”接受后，在HC之间的关系，但不是MDD group.DiscussionWomen与MDD的行为和神经过敏的拒绝。虽然两组都对接受有行为反应，但在MDD中，这与NAcc活性无关。这些研究结果突出了异常的行为和神经反应的社会线索，在抑郁症，疾病的预后和发展的新的和敏感的生物标志物的抑郁症集中在神经通路的社会情感processing.LimitationsConclusions可能仅限于抑郁症的女性在浪漫的背景下。
IntroductionResponding adaptively to one's social environment is a key factor predicting the course of major depressive disorder (MDD). Socially rejecting events can exacerbate, whereas socially accepting events can ameliorate depressive symptoms. The neural responses to rejection and acceptance in MDD are relatively unexplored.MethodsWe used functional magnetic resonance imaging (fMRI) to measure neural responses to romantic rejection and acceptance in women diagnosed with current MDD (n = 19) and a matched group of healthy controls (HCs) (n = 19). During fMRI, participants received rejecting, accepting, and neutral feedback from self-selected potential romantic partners.ResultsIn women with MDD but not HCs, rejection significantly increased activity in the right anterior insula relative to neutral feedback. Greater activation during rejection was found in the dorsal anterior cingulate cortex in MDD compared to HCs. Women with MDD reported stronger emotional responses than HCs to both rejection and acceptance. In addition, left and right nucleus accumbens (NAcc) activity mediated the relationship between trait reward responsiveness and increased ratings of feeling “happy and accepted” following acceptance in HCs, but not the MDD group.DiscussionWomen with MDD were behaviorally and neurally hyperresponsive to rejection. Although both groups were behaviorally responsive to acceptance, in MDD this was dissociated from NAcc activity. These findings highlight abnormal behavioral and neural responses to social cues in MDD, with implications for disease prognosis and the development of novel and sensitive biomarkers for MDD focused on neural pathways for social-affective processing.LimitationsConclusions may be limited to depressed women in a romantic context.
登录
查看更多内容
影响因子：
5.4
作者：
Richman, Laura Smart;Leary, Mark R.
通讯作者：
Leary, Mark R.
影响因子：
--
作者：
Kendler, KS;Hettema, JM;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
17.7
作者：
Kendler, KS;Myers, J;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
7.4
作者：
Kumar, Poornima;Waiter, Gordon D.;Steele, J. Douglas
通讯作者：
Steele, J. Douglas
影响因子：
3.7
作者：
Somerville, Leah H.;Kelley, William M.;Heatherton, Todd F.
通讯作者：
Heatherton, Todd F.