A new approach to restoring visual acuity and stereopsis in adults and children w

恢复成人和儿童视力和立体视觉的新方法

• 批准号: 8730801
• 负责人: Dennis Michael Levi
• 金额: $ 24.47万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8730801
• 关键词: Address; Adult; Affect; Age; Amblyopia; Anisometropia; Binocular Vision; Blindness; Child; Childhood; Clinic; Collaborations; Crossover Design; Cues; Data; Depth Perception; Development; Educational Intervention; Educational process of instructing; Enrollment; Ensure; Environment; Equilibrium; Evaluation; Eye; Feedback; General Population; Goals; Hand; Image; Infant; Intervention; Joints; Life; Measures; Mind; Movement; Outcome Measure; Patients; Performance; Play; Population; Quality of life; Randomized Clinical Trials; Recovery; Refractive Errors; Rehabilitation therapy; Rewards; Site; Strabismus; System; Testing; Training; Video Games; Vision; Visual; Visual Acuity; Work; base; critical period; early experience; effective intervention; improved; monocular; movie; novel; novel strategies; stereoscopic; therapy design; tool; virtual reality; visual cognition; visual motor; young adult

DESCRIPTION Amblyopia is considered to be a permanent reduction in vision that arises from abnormal visual experience early in life, affecting 2-3% of the general population. The primary treatment for amblyopia in children, for the last 250 years has consisted of patching the fellow eye. Patching is considered to be ineffective in adults and is seldom, if ever used. Our main aim is to develop new interventions that embed visual training in active and rewarding visuomotor tasks for restoring both visual acuity and stereopsis in adults and children with amblyopia and to compare it to the traditional treatment of patching. The first such intervention is action videogame playing. This activity enhances aspects of vision in young healthy eyes that are known to be deficient in amblyopic eyes. We ask whether action video game playing may be useful in restoring visual functions in amblyopic eyes. Specifically we will develop and test a customized videogame which enables the presentation of "designer" targets. An important goal is to promote coordination between the two eyes, therefore we will develop a new interface that uses filtering to degrade the image being sent to the fellow eye in order to match the level of the amblyopic eye. Training will therefore require patients to play an action video game with roughly balanced binocular input. While action games appear most effective in enhancing vision in young adults with normal vision, these games are not appropriate for pediatric populations, thus we also propose to develop and test a videogame that is "child friendly" using the same principles. The second intervention, focused directly on retraining stereopsis, is visually guided hand movements in a virtual-reality environment in which we can manipulate different cues to depth and in which patients receive implicit performance feedback embedded in the task. We ask whether this virtual reality training, which capitalizes on our previous work on how monocular and stereo cues combine to support depth perception, may promote fusion and stereopsis. A strength of this joint proposal between UC Berkeley and U of Rochester is in our outcome measures. We will evaluate and quantify a broad range of visual functions including stereopsis in amblyopic subjects. Our pilot data suggests that improving visual acuity and stereopsis is an achievable goal even in adult patients. A commercially available video game has been adapted to the needs of this project in collaboration with game designers, and will be made freely available to eye clinics for a randomized clinical trial if the project is successful.

描述 弱视被认为是一种永久性的视力下降，由异常的视觉体验引起 在生命早期，影响2-3%的总人口。儿童弱视的主要治疗方法， 在过去的250年里，我们一直在修补另一只眼睛。贴片被认为对成人无效， 很少，如果曾经使用过。我们的主要目标是开发新的干预措施，将视觉训练嵌入主动和 奖励视觉运动任务，以恢复成人和儿童的视力和立体视觉， 弱视，并将其与传统的修补治疗进行比较。 第一个这样的干预是动作视频游戏。这项活动提高了年轻人的视力 健康的眼睛，是已知的弱视眼的缺陷。我们会问玩动作游戏 可用于恢复弱视眼的视觉功能。具体来说，我们将开发和测试一个 定制的视频游戏，使“设计师”的目标的介绍。一个重要目标是促进 因此，我们将开发一个新的界面，使用过滤来降低 该图像被发送到对侧眼以匹配弱视眼的水平。培训将 要求患者玩具有大致平衡的双眼输入的动作视频游戏。虽然动作游戏 这些游戏似乎对视力正常的年轻人的视力增强最有效，但这些游戏并不 适合儿童人群，因此我们也建议开发和测试一个视频游戏，是“儿童” “友好”，用同样的原则。 第二个干预，直接集中在重新训练立体视觉，是视觉引导的手部运动， 虚拟现实环境，在其中我们可以操纵不同的线索，以深度和患者接收 任务中隐含的绩效反馈。我们问这种虚拟现实训练， 利用了我们先前关于单眼和立体提示如何结合联合收割机以支持深度感知的工作， 可以促进融合和立体视觉。 加州大学伯克利分校和罗切斯特大学联合提议的一个优点是我们的结果衡量标准。我们 将评估和量化广泛的视觉功能，包括弱视受试者的立体视觉。我们 试验数据表明，即使在成年患者中，改善视敏度和立体视觉也是可实现的目标。一 一个商业可用的视频游戏已经适应了这个项目的需要，与游戏合作， 设计师，并将免费提供给眼科诊所进行随机临床试验，如果该项目是 成功