Self- and Family-Management Intervention in HIV+ Chinese Women

描述（由申请人提供）：本K23申请，响应PA-11-194对NINR的要求，是一个为期3年的以患者为导向的指导研究项目，旨在开发、调整和测试针对中国艾滋病毒阳性妇女的自我和家庭管理干预措施，以改善艾滋病毒健康结果。PI在哥伦比亚大学、加州大学旧金山分校（UCSF）和华盛顿大学（UW）拥有丰富的培训经验，并在国内和国际环境中进行研究。她的长期职业目标是成为艾滋病毒自我和家庭管理领域的独立和富有成效的研究者，在设计和实施文化敏感干预措施方面具有特别的专业知识，并开发，测试，实施，并评估针对美国亚洲艾滋病毒感染者的自我和家庭管理干预措施。该奖项的培训目标是(a)获得定性数据分析方面的专业知识，用于网络文本挖掘目的以及人种学评估；(b)学习性别、性取向和文化适应技能，以便在文化敏感的研究设计中应用；(c)学习干预发展技能，并将其应用于制定针对中国艾滋病毒阳性妇女的行为干预。为实现这些目标而设计的培训活动将包括有指导的独立学习、正式课程作业、参加研究会议，以及在北京设计和实施一个研究项目，在艾滋病毒阳性妇女中试点测试自我和家庭干预管理。这个拟议的研究项目雄心勃勃，但却是可行的，因为它将与Simoni博士在北京正在进行的艾滋病毒阳性患者的工作相协调，并以PI之前在中国上海对艾滋病毒阳性妇女进行的工作为基础。研究项目的具体目标是：(a)对68个深度访谈进行二次定性分析，以进一步阐明中国HIV+妇女的社会文化和家庭背景；(b)制定和采用理论驱动、文化敏感和可行的干预措施，以改善中国HIV+妇女及其家庭的生活质量和临床结果；(c)对10名HIV+妇女及其家庭成员进行自我和家庭管理干预的可行性、依从性和可接受性研究。主要目标是采用格雷的自我和家庭管理框架，适应和发展一种基于证据的文化上适合的自我和家庭管理干预。这一干预措施将帮助艾滋病毒阳性妇女在心理和社会上适应她们的疾病，同时帮助她们减轻压力，提高她们的社会支持水平。在这个过程中，这些妇女还将获得应对艾滋病毒所需的知识和技能。申请人选择了一位在拟研究领域具有丰富经验的导师，并在美国和中国组建了一支杰出的学术合作团队。结合她迄今为止在学术生涯中获得的技能和知识以及拟议研究的结果，申请人将很好地申请作为主要研究者在中国进一步研究艾滋病毒。

DESCRIPTION (provided by applicant): This K23 application, in response to PA-11-194 to NINR, is a 3-year mentored patient-oriented research project to develop, adapt and test a self- and family-management intervention targeting HIV+ women in China to improve HIV health outcomes. The PI has extensive training experience at Columbia, University of California at San Francisco (UCSF), and the University of Washington (UW), and research experience in both domestic and international settings. Her long-term career goal is to be an independent and productive investigator in the field of HIV self- and family-management, with particular expertise in designing and implementing culturally sensitive interventions and to develop, test, implement, and evaluate an intervention in self- and family-management tailored to the Asian HIV+ population in the U.S. Training objectives for this award are to (a) gain expertise in qualitative data analysis for network text mining purposes as well as ethnographic evaluation; (b) learn gender, sexuality, and cultural adaptation skills to apply in a culturally sensitive study design; and (c) learn intervention development skills and apply them in developing a behavioral intervention for HIV+ women in China. The training activities designed to accomplish these objectives will include mentored independent study, formal course work, participation in research conferences, and design and implementation of a research project in Beijing to pilot test self- and family-intervention management among HIV+ women. This proposed research project is ambitious but feasible, as it will be coordinated with Dr. Simoni's ongoing work among HIV+ patients in Beijing and builds upon work that the PI has previously conducted with HIV+ women in Shanghai, China. The specific aims of the research project are to: (a) conduct a secondary qualitative analysis of 68 in-depth interviews to further illuminate the sociocultural and family context of HIV+ Chinese women, (b) develop and adapt a theory-driven, culturally sensitive and feasible intervention to improve the quality of life and clinical outcomes of HIV+ Chinese women and their families, and (c) conduct a feasibility, compliance, and acceptability study for a self- and family-management intervention with 10 HIV+ women and their family members. The main goal is to adapt and develop an evidence-based culturally suitable self- and family-management intervention using Grey's self- and family-management framework. This intervention will assist HIV+ women in adjusting to their illness psychologically and socially, while helping them to decrease stress and enhance their level of social support. In the process, these women will also gain the knowledge and skills they need to cope with HIV. The applicant has chosen a seasoned mentor with extensive experience in the proposed research area, and has assembled a team of eminent academic collaborators across the U.S. and in China. Combining the skills and knowledge she has gained in her academic career thus far with the results of the proposed study, the applicant will be well positioned to submit applications as a principal investigator for further research on HIV in China.