Long Non-coding RNAs in Adipogenesis
脂肪形成中的长非编码RNA
基本信息
- 批准号:8716868
- 负责人:
- 金额:$ 2.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-12-05 至 2013-11-30
- 项目状态:已结题
- 来源:
- 关键词:3T3-L1 CellsAccountingAdipocytesAffectAreaBioinformaticsBiological AssayBiological MarkersCardiovascular DiseasesCell CountCell Differentiation processCell LineCell NucleusCell ProliferationCellsCodeComputing MethodologiesDataData SetDevelopmentDiabetes MellitusDiseaseEpigenetic ProcessEventExpressed Sequence TagsFoundationsFunctional RNAFutureGene Expression ProfileGene Expression RegulationGenesGenetic TranscriptionGenomeGenomicsGrantHumanHuman GenomeLightMammalsMesenchymal Stem CellsMethodsMolecularMolecular BiologyMusNon-Insulin-Dependent Diabetes MellitusNorthern BlottingObesityPlayProcessProteinsPublic HealthRNARNA ProcessingRNA analysisRegulationReportingResearchRoleSignal TransductionSolidStagingStructureTimeTranscriptUntranslated RNAValidationchromatin remodelingdeep sequencingexperiencegenome-widehuman diseaseknock-downlipid biosynthesismammalian genomemouse genomenovelprecursor celltranscriptome sequencing
项目摘要
DESCRIPTION (provided by applicant): The mammalian genomes express a large number of long noncoding RNAs (lncRNAs). Only a handful of them, however, have been studied. The known lncRNAs have diverse roles in the cell, mostly in the nucleus, such as chromatin remodeling, transcription, and RNA processing. Adipogenesis is the process that generates adipocytes from precursor cells, which have many implications for human diseases, such as diabetes and cardiovascular diseases. While regulation of protein-coding genes in adipogenesis has been well studied, the role of lncRNAs is completely unclear. We have sequenced the transcriptomes of human and mouse cells undergoing adipogenesis to an unprecedented depth. Our preliminary analysis indicates that a set of lncRNAs are highly regulated during adipogenesis, suggesting their functional roles in the process. In this grant, we plan to examine known and novel lncRNAs that are regulated in adipogenesis for their roles in differentiation of precursor cells into mature adipocytes.
描述(申请人提供):哺乳动物基因组表达大量长链非编码RNA(lncRNA)。然而,只有少数人被研究过。已知的lncRNA在细胞中具有多种作用,主要在细胞核中,如染色质重塑、转录和RNA加工。脂肪发生是指由前体细胞分化为脂肪细胞的过程,它与糖尿病和心血管疾病等多种人类疾病密切相关。虽然蛋白质编码基因在脂肪形成中的调节已经被很好地研究,但lncRNA的作用完全不清楚。我们已经测序了人类和小鼠细胞的转录组,这些细胞经历了前所未有的深度脂肪形成。我们的初步分析表明,一组lncRNA在脂肪形成过程中受到高度调节,表明它们在该过程中的功能作用。在这项资助中,我们计划研究在脂肪形成中受到调节的已知和新型lncRNA在前体细胞分化为成熟脂肪细胞中的作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
BIN TIAN其他文献
BIN TIAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('BIN TIAN', 18)}}的其他基金
Regulation and Functions of 3'UTRs in Cellular Stress
3UTR 在细胞应激中的调节和功能
- 批准号:
10249371 - 财政年份:2018
- 资助金额:
$ 2.6万 - 项目类别:
Regulation and Functions of 3'UTRs in Cellular Stress
3UTR 在细胞应激中的调节和功能
- 批准号:
10218476 - 财政年份:2018
- 资助金额:
$ 2.6万 - 项目类别:
Digital Gene Expression Analysis by 3’ End Sequencing
通过 3™ 末端测序进行数字基因表达分析
- 批准号:
9048237 - 财政年份:2016
- 资助金额:
$ 2.6万 - 项目类别:
An Integrated System for Deep Sequencing Experiment and Analysis
深度测序实验与分析集成系统
- 批准号:
7839188 - 财政年份:2010
- 资助金额:
$ 2.6万 - 项目类别:
Alternative mRNA processing in cardiac hypertrophy
心脏肥大中的替代 mRNA 加工
- 批准号:
8011375 - 财政年份:2010
- 资助金额:
$ 2.6万 - 项目类别:
Alternative mRNA processing in cardiac hypertrophy
心脏肥大中的替代 mRNA 加工
- 批准号:
7773652 - 财政年份:2010
- 资助金额:
$ 2.6万 - 项目类别:
Analysis of mRNA Polyadenylation across Species and Tissues
跨物种和组织的 mRNA 多腺苷酸化分析
- 批准号:
7883800 - 财政年份:2009
- 资助金额:
$ 2.6万 - 项目类别:
Analysis of mRNA Polyadenylation across Species and Tissues
跨物种和组织的 mRNA 多腺苷酸化分析
- 批准号:
8068636 - 财政年份:2008
- 资助金额:
$ 2.6万 - 项目类别:
相似海外基金
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 2.6万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
- 批准号:
10100360 - 财政年份:2024
- 资助金额:
$ 2.6万 - 项目类别:
Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
- 批准号:
24K04974 - 财政年份:2024
- 资助金额:
$ 2.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
- 批准号:
23K01686 - 财政年份:2023
- 资助金额:
$ 2.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
- 批准号:
23K01692 - 财政年份:2023
- 资助金额:
$ 2.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
- 批准号:
23K01695 - 财政年份:2023
- 资助金额:
$ 2.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
- 批准号:
23K01713 - 财政年份:2023
- 资助金额:
$ 2.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
- 批准号:
2312319 - 财政年份:2023
- 资助金额:
$ 2.6万 - 项目类别:
Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
- 批准号:
23K01715 - 财政年份:2023
- 资助金额:
$ 2.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
- 批准号:
10585388 - 财政年份:2023
- 资助金额:
$ 2.6万 - 项目类别: