Quantitative Stepwise Analysis of RNA Interference

RNA 干扰的定量逐步分析

• 批准号: 9152594
• 负责人: Sua Myong
• 金额: $ 144.78万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9152594
• 关键词: Quantitative; Stepwise; Analysis; RNA; Interference

DP2GM105453‐01                                                                                                                                MYONG, SUA  GRANT TRANSFER APPLICATION  For all transfer applications include also a statement indicating whether the overall research plans/aims have changed from the original submission, and, if so, provide updated information. The overall research plans/aims have not changed from the original submission.

DP2GM105453-01：**SUA： 批准转账申请。 对于所有转让申请，还包括一项声明，表明是否总体上 研究计划/目标已从最初提交的文件更改，如果更改，请提供 更新信息。 总体研究计划/目标与最初提交的文件没有变化。

项目成果

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.

• DOI: 10.1038/s41586-018-0209-9
• 发表时间: 2018-06
• 期刊: Nature
• 影响因子: 64.8
• 作者: Chen MC;Tippana R;Demeshkina NA;Murat P;Balasubramanian S;Myong S;Ferré-D'Amaré AR
• 通讯作者: Ferré-D'Amaré AR

Visualizing repetitive diffusion activity of double-strand RNA binding proteins by single molecule fluorescence assays.

通过单分子荧光测定可视化双链 RNA 结合蛋白的重复扩散活性。

• DOI: 10.1016/j.ymeth.2016.03.009
• 发表时间: 2016
• 期刊: Methods (San Diego, Calif.)
• 作者: Koh,HyeRan;Wang,Xinlei;Myong,Sua
• 通讯作者: Myong,Sua

G-quadruplex conformation and dynamics are determined by loop length and sequence.

• DOI: 10.1093/nar/gku464
• 发表时间: 2014-07
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Tippana R;Xiao W;Myong S
• 通讯作者: Myong S

RNA stem structure governs coupling of dicing and gene silencing in RNA interference.

• DOI: 10.1073/pnas.1710298114
• 发表时间: 2017-11-28
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Koh HR;Ghanbariniaki A;Myong S
• 通讯作者: Myong S

Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing.

• DOI: 10.1093/nar/gku523
• 发表时间: 2014-07
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Koh HR;Xing L;Kleiman L;Myong S
• 通讯作者: Myong S