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Chromatin Remodeling and Transcription Repression

Chromatin Remodeling and Transcription Repression
染色质重塑和转录抑制
批准号：
8208112
负责人：
Blaine Bartholomew
金额：
$31.73万
依托单位：
SOUTHERN ILLINOIS UNIVERSITY CARBONDALE
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
项目状态：
已结题
起止时间：
2004-04-01 至 2013-11-30
来源：
https://reporter.nih.gov/project-details/8208112
关键词：
ATPase DomainArchitectureBackBiochemicalBiological ProcessCatalytic DomainCellsChromatinChromatin Remodeling FactorChromosomesCodeComplexDNADNA PackagingDeletion MutagenesisDeletion MutationDevelopmentGene ExpressionGenesGenetic TechniquesGenomicsGoalsHealthHistonesISWIISWI Family ProteinIn VitroMediatingMethodsMolecularMolecular GeneticsNucleosomesProcessPropertyProteinsRNA Polymerase IIRNA chemical synthesisReadingRegulationRepressionRoleSeriesSiteSmall Interfering RNAStagingStem cellsStructureTechniquesTertiary Protein StructureTranscription ElongationUntranslated RNAcell typecellular developmentchromatin remodelingcrosslinkdomain mappingenzyme activitygene repressiongenetic analysishistone modificationin vivomacromolecular assemblymutantnovelprotein protein interactionrepairedtranscription terminationtumorigenesisyeast genetics

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中文摘要
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英文摘要
Project Summary: The ISWI type chromatin remodeling complexes have been shown to be involved in transcription repression, and the regulation of transcription elongation and termination. Reorganization of chromatin and regions in chromosomes are fundamental in cellular development and differentiation. We propose to further our understanding of these processes by a two-prong approach of (1) extensive biochemical characterization of the ISWI family of proteins and (2) the molecular genetic analysis of mutant versus wild type ISWI complexes in vivo.
期刊论文(3)
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科研奖励(0)
会议论文
ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps.
DOI： 10.1016/j.cell.2012.12.040
发表时间： 2013-01-31
期刊： Cell
影响因子： 64.5
作者： [Deindl S, Hwang WL, Hota SK, Blosser TR, Prasad P, Bartholomew B, Zhuang X]
通讯作者： Zhuang X
ISWI chromatin remodeling: one primary actor or a coordinated effort?
DOI： 10.1016/j.sbi.2014.01.010
发表时间： 2014-02
期刊： Current opinion in structural biology
影响因子： 6.8
作者： [Bartholomew B]
通讯作者： Bartholomew B
Regulation of RNA polymerase II pausing and directionality by ATP-dependent chromatin remodelers
Regulation of RNA polymerase II pausing and directionality by ATP-dependent chromatin remodelers
Regulation of chromatin organization and dynamics by INO80
The interplay between the chromatin remodeler INO80 and histone variant H2A.Z.
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