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Chromatin Remodeling and Transcription Repression

Chromatin Remodeling and Transcription Repression
染色质重塑和转录抑制
批准号：
7995660
负责人：
Blaine Bartholomew
金额：
$14.13万
依托单位：
SOUTHERN ILLINOIS UNIVERSITY CARBONDALE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-02-12 至 2010-12-31
来源：
https://reporter.nih.gov/project-details/7995660
关键词：
ATPase DomainArchitectureBackBiochemicalBiological ProcessCatalytic DomainCellsChromatinChromatin Remodeling FactorChromosomesCodeComplexDNADNA PackagingDeletion MutagenesisDeletion MutationDevelopmentGene ExpressionGenesGenetic TechniquesGenomicsGoalsHealthHistonesISWIISWI Family ProteinIn VitroMediatingMethodsMolecularMolecular GeneticsNucleosomesProcessPropertyProteinsRNA Polymerase IIRNA chemical synthesisReadingRegulationRepressionRoleSeriesSiteSmall Interfering RNAStagingStem cellsStructureTechniquesTertiary Protein StructureTranscription ElongationUntranslated RNAcell typecellular developmentchromatin remodelingcrosslinkdomain mappingenzyme activitygene repressiongenetic analysishistone modificationin vivomacromolecular assemblymutantnovelprotein protein interactionrepairedtumorigenesisyeast genetics

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英文摘要
Project Summary: The ISWI type chromatin remodeling complexes have been shown to be involved in transcription repression, and the regulation of transcription elongation and termination. Reorganization of chromatin and regions in chromosomes are fundamental in cellular development and differentiation. We propose to further our understanding of these processes by a two-prong approach of (1) extensive biochemical characterization of the ISWI family of proteins and (2) the molecular genetic analysis of mutant versus wild type ISWI complexes in vivo.
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Regulation of RNA polymerase II pausing and directionality by ATP-dependent chromatin remodelers
Regulation of RNA polymerase II pausing and directionality by ATP-dependent chromatin remodelers
Regulation of chromatin organization and dynamics by INO80
The interplay between the chromatin remodeler INO80 and histone variant H2A.Z.
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