Drosophila Genomics Resource Center

描述（申请人提供）：果蝇是动物遗传学、发育和调控研究的杰出模型之一。作为一种遗传模式，它比任何其他后生动物的特征更充分。与此同时，由于进化上的保守性，果蝇已成为医学、农业和生物技术基础研究的重要模型。因此，似乎超过75%的人类疾病基因具有果蝇同源物。完成的果蝇基因组序列，正在进行的EST项目，以及越来越多的 果蝇工作者对高通量基因组学技术的应用为果蝇的全面功能基因组学研究铺平了道路。为了实现这一目标，社区需要随时、经济地获得有质量保证的基因组材料。Drosophila Genomics Resource Center（DGRC）为研究界提供基因组学资源，并促进其有效利用。具体而言，DGRC：1。通过获取、存档、管理和分发基因组学资源，包括克隆、载体、细胞系和微阵列，确保研究社区广泛获得基因组学资源。2.通过提供基于网络的描述性文件，协议和指南，促进研究界有效利用基因组学资源;电子邮件和电话帮助台;会议外展;和研讨会。3.改善研究社区可用的基因组学资源和协议。

DESCRIPTION (provided by applicant): Drosophila is one of the outstanding models for studies of animal genetics, development, and regulation. As a genetic model, it has been characterized more fully than any other metazoan. At the same time, because of evolutionary conservation, Drosophila has turned out to be an important model for fundamental studies of medical, agricultural, and biotechnological interest. Thus, it appears that >75 percent of human disease genes have Drosophila homologs. The completed Drosophila genome sequence, ongoing EST projects, and the increasing application of high-throughput genomics techniques by fly workers are paving the way for a comprehensive functional genomics of Drosophila. To reach this goal, the community requires ready, economical access to quality-assured genomics materials. The Drosophila Genomics Resource Center (DGRC) provides the research community with access to genomics resources and facilitates their effective use. Specifically, the DGRC: 1. Ensures the research community broad access to genomics resources by acquiring, archiving, curating, and distributing genomics resources including, clones, vectors, cell lines, and microarrays. 2. Facilitates the effective use of genomics resources by the research community by providing web based descriptive documentation, protocols, and guidelines; email and telephone help desk; outreach at conferences; and workshops. 3. Improves the genomics resources and protocols available to the research community.