Drosophila Genomics Resource Center

描述（申请人提供）：果蝇是遗传学、发育、基因调控、系统生物学和神经生物学研究的重要模型。从遗传学上讲，它是最具特征的后生动物。由于进化上的保守性，果蝇已成为医学、农业和环境兴趣基础研究的重要模型。对于医学来说，重要的是不仅使用果蝇允许对高度保守的过程进行严格、高分辨率的研究，而且>75%的人类疾病基因具有果蝇同源物，并且可以研究重要疾病的果蝇模型。最近，果蝇系统生物学的知识将成为利用基因组学研究环境影响（例如对其他节肢动物）和环境毒物对公众健康后果的核心。高通量基因组学技术在果蝇研究中的应用日益广泛，为果蝇功能基因组学的全面研究铺平了道路。为了实现这一目标，社区已经并将继续需要随时、经济地获得这些努力产生的基因组材料。果蝇基因组学资源中心（Drosophila Genomics Resource Center，DGRC）为研究界提供这些资源的访问权限，并促进其有效利用。具体而言，DGRC：1。通过获取、存档、管理和分发资源（包括克隆、载体和细胞系），提供对基因组学资源的广泛访问。2.通过提供基于网络的文档、协议和指南;电子邮件和电话帮助;会议外展;和研讨会，促进基因组学资源的有效利用。3.通过其在新兴技术上的努力--寻求新资源和开发新协议--它为使用这些基因组学资源开辟了新的机会。DGRC对果蝇研究界很重要。DGRC在3400个实验室中拥有7500名用户（累积8年），每年增加600名用户，每年运送2000多份材料。用户调查记录了这些努力对果蝇研究人员的重要性。

DESCRIPTION (provided by applicant): Drosophila is an important model for the study of genetics, development, gene regulation, systems biology and neurobiology. Genetically, it is the most fully characterized metazoan. Because of evolutionary conservation, Drosophila has turned out to be an important model for fundamental studies of medical, agricultural, and environmental interest. For medicine it is important not only that the use of Drosophila permits rigorous, high resolution study of highly conserved processes but that >75% of human disease genes have Drosophila homologs and that Drosophila models of important diseases can be studied. More recently it has become apparent that knowledge of the systems biology of Drosophila will be central to the use of genomics to study the environmental impact (e.g. on other arthropods) and public health consequences of environmental toxicants. The increasing application of high-throughput genomics techniques by fly workers is paving the way for a comprehensive functional genomics of Drosophila. To reach this goal, the community has required - and continues to require ~ ready, economical access to the genomics materials produced by these efforts. The Drosophila Genomics Resource Center (DGRC) provides the research community with access to these resources and facilitates their effective use. Specifically, the DGRC: 1. Provides broad access to genomics resources by acquiring, archiving, curating, and distributing resources including, clones, vectors, and cell lines. 2. Facilitates effective use of genomics resources by providing web based documentation, protocols, and guidelines; email and telephone help; outreach at conferences; and workshops. 3. Through its efforts on Emerging Technologies ~ soliciting new resources and developing new protocols ~ it opens new opportunities for the use of these genomics resources. The DGRC is important to the Drosophila research community. The DGRC has 7500 users (cumulative over 8 years) in 3400 laboratories, adds 600 users per year, and makes >2000 shipments of materials per year. User surveys document the importance of these efforts to Drosophila researchers.