The Meningioma Consortium: Genome-Wide Association Study

脑膜瘤联盟:全基因组关联研究

基本信息

  • 批准号:
    8547782
  • 负责人:
  • 金额:
    $ 59.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-07-01 至 2017-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary/ Abstract Meningioma is the most common primary brain tumor, present in up to one percent of adults, and although often considered benign, has survival comparable to breast cancer. Information on risk factors is extremely limited. In an effort to better define such factors, we are conducting a comprehensive population-based, case/control study of meningioma that includes 1600 cases and 1600 controls drawn from Massachusetts, Connecticut, North Carolina, California and Texas. This will represent the largest population-based collection of meningioma cases worldwide, with more than double the number of cases of any existing study. We are currently collecting biological specimens, and extensive exposure and phenotypic data with funding from the National Institutes of Health (NIH R01s CA109468, CA109461, CA109745, CA108473, and CA109475). In this application we request funds to genotype the study subjects to find inherited risk loci for meningioma. Our aims are to 1) Conduct the first genome wide association study (GWAS) of meningioma using the 1360 Caucasian cases from our ongoing case/control project and 3420 Caucasian controls drawn from the first half of three control series a) 600 controls from our ongoing case/control project, b) 1699 controls from Illumina iControlDB and c) 1121 controls from the Cancer Genetic Markers of Susceptibility (CGEMs) study, 2) Using 700 additional Caucasian meningioma subjects drawn from our clinical series and the second half of the above mentioned controls (n=3420), replicate candidates from Aim 1 that yielded p<10-5 for association with meningioma. Variants with p < 5.0*10-8 will be considered significant for genome wide association with meningioma risk from combined stage 1 and stage 2 analyses, 3) Replicate previous associations from the Interphone study8a of meningioma risk with variants in BRIP1 (the breast cancer susceptibility gene (BRCA1)-interacting protein) and ATM (ataxia telangiectasia mutated gene) and 4) Replicate previous associations from the Tineas Capitas study of meningioma risk with variants in DNA repair genes (KRAS2, ERCC2, CCND1).107 The proposed genetic analyses would represent the first GWAS data for meningioma and also provide important replication of previously observed associations with strong biological plausibility given the established association between meningioma risk and ionizing radiation. Identification of risk loci for meningioma will likely have strong etiologic significance with importance for both prevention and treatment.
项目摘要/摘要

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Elizabeth B. Claus其他文献

Optimizing participant and community engagement in cancer genomic sequencing research
优化癌症基因组测序研究中的参与者和社区参与度
  • DOI:
    10.1016/j.gim.2025.101483
  • 发表时间:
    2025-09-01
  • 期刊:
  • 影响因子:
    6.200
  • 作者:
    Norah L. Crossnohere;Anne L.R. Schuster;Cindy K. Blair;Hasani Bland;John D. Carpten;Elizabeth B. Claus;Graham A. Colditz;Diane Diehl;Li Ding;Bettina F. Drake;Ryan C. Fields;Suzanne George;Katherine Janeway;Hyoshin Kim;Heinz-Josef Lenz;Jennifer W. Mack;Charité Ricker;Mariana C. Stern;Andrew Sussman;Jeffrey Trent;Zachary Crees
  • 通讯作者:
    Zachary Crees
Distribution of copy number alterations and impact of chromosome arm call thresholds for meningioma
脑膜瘤拷贝数改变的分布及染色体臂调用阈值的影响
  • DOI:
    10.1038/s41467-025-60734-0
  • 发表时间:
    2025-07-02
  • 期刊:
  • 影响因子:
    15.700
  • 作者:
    Ruchit V. Patel;Hia S. Ghosh;David M. Meredith;Scott Ryall;Elizabeth B. Claus;Rameen Beroukhim;Azra H. Ligon;Sandro Santagata;Wenya Linda Bi
  • 通讯作者:
    Wenya Linda Bi
Targeting IDH in Low-Grade Glioma.
针对低级别胶质瘤的 IDH。
Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation
接受放化疗的胶质母细胞瘤患者的发病率、危险因素和住院原因
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    R. Rahman;P. Catalano;D. Reardon;A. Norden;P. Wen;E. Lee;L. Nayak;R. Beroukhim;Ian F. Dunn;A. Golby;Mark D. Johnson;E. Chiocca;Elizabeth B. Claus;Elizabeth B. Claus;B. Alexander;Nils D. Arvold
  • 通讯作者:
    Nils D. Arvold
Integrative Copy Number and Mutational Analysis Improves Glioma Diagnostics
  • DOI:
    10.1016/j.cancergen.2014.06.011
  • 发表时间:
    2014-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Shakti H. Ramkissoon;Wenya L. Bi;Steven E. Schumacher;Lori A. Ramkissoon;Sam Haidar;Adrian M. Dubuc;Loreal Brown;Margot Burns;Jane Cryan;David A. Reardon;Eudocia Q. Lee;Mikael L. Rinne;Andrew D. Norden;Lakshmi Nayak;Sandra Ruland;Lisa M. Doherty;Debra C. LaFrankie;Andrea Russo;Nils D. Arvold;Elizabeth B. Claus
  • 通讯作者:
    Elizabeth B. Claus

Elizabeth B. Claus的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Elizabeth B. Claus', 18)}}的其他基金

Administrative Core
行政核心
  • 批准号:
    10294463
  • 财政年份:
    2021
  • 资助金额:
    $ 59.8万
  • 项目类别:
Participant Engagement Unit
参与者参与单元
  • 批准号:
    10294464
  • 财政年份:
    2021
  • 资助金额:
    $ 59.8万
  • 项目类别:
Genome Characterization Unit
基因组表征单位
  • 批准号:
    10923429
  • 财政年份:
    2021
  • 资助金额:
    $ 59.8万
  • 项目类别:
OPTimIzing engageMent in discovery of molecular evolution of low grade glioma (OPTIMUM)
优化低级别神经胶质瘤分子进化发现的参与(OPTIMUM)
  • 批准号:
    10294462
  • 财政年份:
    2021
  • 资助金额:
    $ 59.8万
  • 项目类别:
Participant Engagement Unit
参与者参与单元
  • 批准号:
    10491842
  • 财政年份:
    2021
  • 资助金额:
    $ 59.8万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10491839
  • 财政年份:
    2021
  • 资助金额:
    $ 59.8万
  • 项目类别:
OPTimIzing engageMent in discovery of molecular evolution of low grade glioma (OPTIMUM)
优化低级别神经胶质瘤分子进化发现的参与(OPTIMUM)
  • 批准号:
    10491794
  • 财政年份:
    2021
  • 资助金额:
    $ 59.8万
  • 项目类别:
The Meningioma Consortium: Genome-Wide Association Study
脑膜瘤联盟:全基因组关联研究
  • 批准号:
    8332667
  • 财政年份:
    2010
  • 资助金额:
    $ 59.8万
  • 项目类别:
The Meningioma Consortium: Genome-Wide Association Study
脑膜瘤联盟:全基因组关联研究
  • 批准号:
    8089585
  • 财政年份:
    2010
  • 资助金额:
    $ 59.8万
  • 项目类别:
Meningioma: Risk Factors and Quality of Life
脑膜瘤:危险因素和生活质量
  • 批准号:
    7228421
  • 财政年份:
    2006
  • 资助金额:
    $ 59.8万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了