Inhibitors of Inducible Nitric Oxide Synthase (iNOS) Regulation as a Basis for Novel Anti-Infective Agents

人类的iNOS酶产生活性氮物质，这些活性氮物质是细胞内杀死病原体如细菌和寄生虫所必需的。最近，我们发现SPSB蛋白是这种重要酶的关键调节剂，干扰这种调节增强了iNOS的抗微生物作用。该项目将开发SPSB-iNOS相互作用的小分子抑制剂，用作人类的新型抗感染药物。

The human enzyme iNOS generates reactive nitrogen species that are required for the intracellular killing of pathogens such as bacteria and parasites. Recently, we showed that the SPSB proteins are key regulators of this important enzyme, and that interfering with this regulation enhanced the anti-microbial actions of iNOS. This project will develop small molecule inhibitors of the SPSB-iNOS interaction for use as novel anti-infective agents in humans.