RCMI Translational Research Network (RTRN)

说明(申请人提供)：过早发病率和死亡率过高的个人，包括种族和族裔少数群体、社会经济地位低的人和农村人，被视为健康差距人群。“转化性研究”是一种双向过程，其重点是将基本科学发现“转化”为健康干预措施，然后转化为临床实践，以改善患者护理和人群健康，已被提出为减少健康差距的重要途径。将这些人口与新的健康进步联系起来，需要有效的健康教育，让更多的少数群体参与者参与临床试验，培养更多的少数群体研究人员，并加强少数群体机构的研究基础设施。RCMI转译研究网络(RTRN)的建立是为了利用现有的体力和智力资源，促进和支持相关的多地点临床和转译研究，重点是缩小健康差距和改善健康结果。为了在五年的基础设施增长的基础上再接再厉，由美国国立卫生研究院资助的少数民族机构研究中心(RCMI)组成的财团已经联合起来，提交了网络的续签申请。RTRN将继续协同和协调基础、临床和社区研究人员中相当多的多学科人才，以获得关于健康差距的社会、经济、行为、文化、环境、围产期和基因决定因素的新知识。根据第一个五年的成功和RTRN评估产生的数据，以及RCMI指导委员会和外部咨询委员会的重要投入，提出了以下具体目标：具体目标1：加强和简化RTRN的总体管理和业务；具体目标2：让RCMI调查人员和其他利益攸关方，包括外行社区参与，以加强多地点临床和转化性研究的能力；具体目标3：加强项目管理、绩效监测和数据分析的基础设施；以及具体目标4.加强开发和采用传播研究结果的最佳做法，以减少健康差距和改善疾病结果。

DESCRIPTION (provided by applicant): Individuals who suffer from disproportionately high rates of premature morbidity and mortality, including racial and ethnic minorities, those of low socioeconomic status, and rural persons, are considered health disparity populations. "Translational Research", a bidirectional process focused on "translating" basic scientific discoveries into health interventions, and then into clinical practice to improve patient care and population health, has been proposed as an important approach to reduce health disparities. Connecting these populations to new health advances requires effective health education, engaging more minority participants in clinical trials, producing more minority investigators and enhancing research infrastructure at minority institutions. RCMI Translational Research Network (RTRN) have been developed to leverage the existing physical and intellectual resources and to promote and support relevant multi-site clinical and translational research focused on reducing health disparities and improving health outcomes. To build upon five years of infrastructure growth, the consortium of NIH-funded Research Centers in Minority Institutions (RCMI) has come together to submit for a renewal for the network. RTRN will continue to synergize and coordinate the considerable multidisciplinary talents of basic, clinical and community investigators to gain new knowledge about the social, economic, behavioral, cultural, environmental, perinatal and genetic determinants of health disparities. Based on the success of the first five years and the data arising from the RTRN evaluation, as well as critical input from the RCMI Steering and External Advisory Committees, the following specific aims are proposed: Specific Aim 1: Enhance and streamline overall RTRN management and operations; Specific Aim 2: Engage RCMI investigators and other stakeholders, including the lay community, to strengthen capacity for multi-site clinical and translational research; Specific Aim 3: Enhance the infrastructure for project management, performance monitoring and data analysis; and Specific Aim 4.- Enhance the development and adoption of best practices for disseminating research findings to reduce health disparities and improve disease outcomes.