Computerized Impulsive Rotational Test (CIRT) for Evaluation of Patients with Com

描述（由申请人提供）：对平衡和平衡抱怨患者的医学评估包括对其前庭功能的评估。然而，前庭功能的标准临床试验有许多局限性，降低了其提供充分评估前庭功能的能力。计算机脉冲旋转试验（CIRT）有潜力克服标准临床试验的局限性。该提案的目标是在neurokinetics公司生产的商业化临床旋转测试系统上开发和集成这种新的旋转测试。该I期SBIR提案的目标是开发额外的硬件、分析软件和临床方案，以适应目前商业化的临床旋转测试系统，即Neuro Kinetics公司（NKI） I- portal (R)神经耳科测试中心（NOTC）系统，用于在有限数量的受试者和前庭患者上执行这项新测试并验证结果。该项目的长期目标是验证CIRT的临床效率，并将该测试用于识别和表征前庭功能不对称的严重程度。这个第一阶段SBIR的直接目标由这个应用程序的两个特定目标描述。第一个目标是开发CIRT的临床版本：结合刺激传递、数据采集和数据分析，用于由Neuro Kinetics公司制造的现有商业旋转测试系统。第二个目标是通过对10名前庭功能正常的受试者和20名证实前庭功能丧失的受试者进行测试，将CIRT与传统的前庭测试进行比较。测试将在临床前庭实验室进行，并将提供反馈，用于评估测试舒适性和改进分析软件的用户界面。临床试验的结果将用于在II期SBIR试验方案之前优化CIRT。

DESCRIPTION (provided by applicant): The medical evaluation of patients with balance and equilibrium complaints includes an assessment of their vestibular function. However, standard clinical tests of vestibular function have a number of limitations that reduce their ability to provide an adequate assessment of vestibular function. The Computerized Impulsive Rotational Test (CIRT) has the potential to overcome limitations of standard clinical tests. The goal of this proposal is to develop and integrate this new rotation test on a commercial clinical rotation test system manufactured by Neuro Kinetics, Inc. Project Summary The goal of this Phase I SBIR proposal is to develop the additional hardware, analysis software, and clinical protocol necessary to adapt a currently commercially available clinical rotation test system, i.e., the Neuro Kinetics, Inc. (NKI) I-Portal(R) Neuro-Otologic Test Center (NOTC) system for performing this new test and validating results on a limited number of subjects and vestibular patients. The long-term aim of this project is to verify the clinical efficiency of CIRT and sell this test to idntify and characterize the severity of an asymmetry of vestibular function. The immediate goals of this Phase I SBIR are described by the two Specific Aims of this application. The first aim is to develop a clinical version of the CIRT: Incorporate stimulus delivery, data acquisition, and data analysis for an existing commercial rotational test system manufactured by Neuro Kinetics, Inc. The second aim will compare the CIRT to conventional vestibular testing by performing tests on 10 subjects with normal vestibular function and 20 subjects with a verified vestibular loss of vestibular function. The tests will be performed in a clinical vestibular laboratory and will provie feedback that will be used to evaluate test comfort and to improve the user interface to the analysis software. The results from the clinical tests will be used to optimize the CIRT in advance of a Phase II SBIR test protocol. PUBLIC HEALTH RELEVANCE: The medical evaluation of patients with balance and equilibrium complaints includes an assessment of their vestibular function. However, standard clinical tests of vestibular function have a number of limitations that reduce their ability to provide an adequate assessment of vestibular function. The Computerized Impulsive Rotational Test (CIRT) has the potential to overcome limitations of standard clinical tests. The goal of this proposal is to develop and integrate this new rotation test on a commercial clinical rotation test system manufactured by Neuro Kinetics, Inc.