Computerized Impulsive Rotational Test (CIRT) for Evaluation of Patients with Com

用于评估 Com 患者的计算机脉冲旋转测试 (CIRT)

• 批准号: 8392545
• 负责人: ALEXANDER D KIDERMAN
• 金额: $ 14.63万
• 依托单位: NEUROLIGN USA, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-03 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8392545
• 关键词: Acceleration; Bilateral; Caloric Tests; Clinical; Clinical Protocols; Clinical Trials; Computer software; Data Analyses; Data Collection; Diagnosis; Effectiveness; Equilibrium; Evaluation; Eye Movements; Feedback; Generations; Goals; Grant; Head; Kinetics; Knowledge; Laboratories; Medical; Modification; Motion Sickness; Nausea; Patients; Phase; Procedures; Protocols documentation; Reporting; Rotation; Semicircular canal structure; Severities; Small Business Innovation Research Grant; Stimulus; System; Testing; Time; Vestibular Function Tests; Vestibular loss; Work; commercialization; computerized; data acquisition; design; equilibration disorder; evaluation/testing; improved; phase 2 study; research clinical testing; restraint; user-friendly

DESCRIPTION (provided by applicant): The medical evaluation of patients with balance and equilibrium complaints includes an assessment of their vestibular function. However, standard clinical tests of vestibular function have a number of limitations that reduce their ability to provide an adequate assessment of vestibular function. The Computerized Impulsive Rotational Test (CIRT) has the potential to overcome limitations of standard clinical tests. The goal of this proposal is to develop and integrate this new rotation test on a commercial clinical rotation test system manufactured by Neuro Kinetics, Inc. Project Summary The goal of this Phase I SBIR proposal is to develop the additional hardware, analysis software, and clinical protocol necessary to adapt a currently commercially available clinical rotation test system, i.e., the Neuro Kinetics, Inc. (NKI) I-Portal(R) Neuro-Otologic Test Center (NOTC) system for performing this new test and validating results on a limited number of subjects and vestibular patients. The long-term aim of this project is to verify the clinical efficiency of CIRT and sell this test to idntify and characterize the severity of an asymmetry of vestibular function. The immediate goals of this Phase I SBIR are described by the two Specific Aims of this application. The first aim is to develop a clinical version of the CIRT: Incorporate stimulus delivery, data acquisition, and data analysis for an existing commercial rotational test system manufactured by Neuro Kinetics, Inc. The second aim will compare the CIRT to conventional vestibular testing by performing tests on 10 subjects with normal vestibular function and 20 subjects with a verified vestibular loss of vestibular function. The tests will be performed in a clinical vestibular laboratory and will provie feedback that will be used to evaluate test comfort and to improve the user interface to the analysis software. The results from the clinical tests will be used to optimize the CIRT in advance of a Phase II SBIR test protocol. PUBLIC HEALTH RELEVANCE: The medical evaluation of patients with balance and equilibrium complaints includes an assessment of their vestibular function. However, standard clinical tests of vestibular function have a number of limitations that reduce their ability to provide an adequate assessment of vestibular function. The Computerized Impulsive Rotational Test (CIRT) has the potential to overcome limitations of standard clinical tests. The goal of this proposal is to develop and integrate this new rotation test on a commercial clinical rotation test system manufactured by Neuro Kinetics, Inc.

描述（由申请人提供）：对有平衡和平衡投诉的患者进行的医学评估包括对其前庭功能的评估。然而，前庭功能的标准临床测试具有许多限制，这些限制降低了它们提供前庭功能的充分评估的能力。计算机化冲动旋转测试（CIRT）有可能克服标准临床测试的局限性。本提案的目标是在Neuro Kinetics，Inc.制造的商业临床旋转测试系统上开发和集成这种新的旋转测试。项目概述本SBIR第一阶段提案的目标是开发额外的硬件、分析软件和临床方案，以适应目前市售的临床旋转测试系统，即，神经动力学公司(NKI)I-Portal（R）神经耳科测试中心（NOTC）系统用于执行这种新的测试并验证有限数量的受试者和前庭患者的结果。本项目的长期目标是验证CIRT的临床有效性，并销售该测试以识别和表征前庭功能不对称的严重程度。本申请的两个具体目标描述了第I阶段SBIR的近期目标。第一个目标是开发CIRT的临床版本：为Neuro Kinetics，Inc.制造的现有商业旋转测试系统整合刺激输送、数据采集和数据分析。第二个目的是通过对10名前庭功能正常的受试者和20名经验证的前庭功能丧失的受试者进行测试，将CIRT与传统前庭测试进行比较。测试将在临床前庭实验室进行，并将提供反馈，用于评估测试舒适度和改善分析软件的用户界面。临床试验的结果将用于在II期SBIR试验方案之前优化CIRT。 公共卫生关系：对有平衡和平衡主诉的患者的医学评估包括对他们前庭功能的评估。然而，前庭功能的标准临床测试具有许多限制，这些限制降低了它们提供前庭功能的充分评估的能力。计算机化冲动旋转测试（CIRT）有可能克服标准临床测试的局限性。本提案的目标是在Neuro Kinetics，Inc.制造的商业临床旋转测试系统上开发和集成这种新的旋转测试。