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Sensorimotor integration underlying hand control in Carpal Tunnel Syndrome

腕管综合症中手部控制的感觉运动整合

基本信息

批准号：
8325562
负责人：
MARCO SANTELLO
金额：
$ 17.86万
依托单位：
ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-30 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8325562
关键词：
Address Adult Affect Age Behavior Carpal Tunnel Syndrome Clinical Complex Data Digit structure Disease Drops Ensure Feedback Fingers Freedom Friction Gender Hand Hand functions Impairment Individual Knowledge Lateral Lead Learning Left Location Manuals Maps Measures Medial Memory Modeling Motor Muscle Musculoskeletal Diseases Nerve Nerve compression syndrome Neurologic Neuromuscular Diseases Neuropathy Neurosciences Outcome Patient Self-Report Patients Performance Population Process Property Public Health Quality of life Randomized Relative (related person)Research Research Proposals Ring Finger Domain Role Sensory Severities Spatial Distribution Surface Syndrome Tactile Testing Texture Thumb structure United States Visual Weight clinical application design grasp improved indexing insight lifetime risk median nerve motor control motor deficit nervous system disorder pressure receptor response sensory feedback skeletal disorder somatosensory

项目摘要

Effective control of object grasping and manipulation relies on the ability to adjust forces of individual digits to the properties of the object being grasped such as its weight, center of mass or texture. These adjustments rely on (a) detecting object properties through sensory feedback derived primarily from receptors in the fingertips and hand muscles and (b) integrating this feedback with activation of hand muscles appropriate for grasping and manipulation. However, the fine tuning of hand muscle activity to object properties can be disrupted by a number of neurological and musculo-skeletal diseases such as Carpal Tunnel Syndrome (CTS). This compresion neuropathy of the median nerve is one of the most common and debilitating diseases affecting hand function. CTS results in self-reported loss of manual dexterity (e.g., difficulties with fine manipulation, dropping objects, etc.) which is due to somatosensory deficits in the thumb, index, middle and lateral half of the ring finger, and, in severe cases, motor deficits in the thumb. As whole- hand grasping require sensing object properties from all digits to accurately adjust their forces, the study of CTS offers a unique opportunity to improve our understanding the mechanisms underlying sensorimotor integration during whole-hand grasping and manipulation. This primary objective will be pursued by using CTS as a research model to address these important questions of sensorimotor control of grasping. An additional secondary objective is to use the results of the proposed research to improve our understanding of the extent to which increasing impairment in nerve function affects sensorimotor transformations necessary for learning and executing specific aspects of skilled object manipulation. We will pursue two Specific Aims: (1) to quantify the extent to which patients with CTS are able to coordinate all digit forces and contact points when altering object properties (center of mass, weight and texture) and their predictability during five-digit grasping; and (2) to determine the extent to which patients with CTS are able to coordinate digit forces as a function of the number of digits (two, three, four, and five) involved in the grasp. In both Aims, multi-dimensional measures of grasp control from patients with mild and moderately severe CTS will be compared with those obtained from age- and gender-matched healthy controls. The objectives of the proposed research are relevant to public health as they address a debilitating neuromuscular disease of the hand, Carpal Tunnel Syndrome (CTS), that affects the quality of life in 6 to 14 million adults in the United States. We propose to use CTS as a model to improve our understanding of the mechanisms underlying sensorimotor integration responsible for skilled object manipulation. The knowledge gained through our proposed research will provide significant insight into how electrodiagnostic measures of nerve function relate to specific aspects of grasp control, thus improving the interpretability and applications of these clinical measures.

物体抓取和操纵的有效控制依赖于个体力量的调节能力数字与被抓物体的属性，如重量、质心或质地。这些调整依赖于（a）通过主要来自受体的感觉反馈来检测对象特性以及（B）将该反馈与手部肌肉的激活相结合适合抓握和操作。然而，手部肌肉活动对物体的微调一些神经和肌肉骨骼疾病，如腕管综合征，综合征（CTS）。这种正中神经的扩张性神经病是最常见的，影响手功能的衰弱性疾病。CTS导致自我报告的手部灵活性丧失（例如，精细操作困难、掉落物体等）这是由于拇指的躯体感觉缺陷，无名指的食指、中指和侧半部分，在严重的情况下，拇指的运动缺陷。整体而言- 手抓握需要从所有手指感知物体属性，以准确地调整它们的力量， CTS提供了一个独特的机会，以提高我们的理解机制的感觉运动在全手抓握和操作过程中的整合。这一主要目标将通过使用 CTS作为一个研究模型，以解决这些重要的问题的感觉运动控制的把握。一个另一个次要目标是利用拟议研究的结果来提高我们的认识神经功能受损程度的增加影响感觉运动转换学习和执行熟练的对象操作的特定方面所必需的。我们将追求两个具体目标：（1）量化CTS患者能够在多大程度上协调所有手指的力量和接触点时，改变对象属性（质心，重量和纹理）及其在五指抓握期间的可预测性;以及（2）确定患者 CTS能够协调手指力量作为手指数量的函数（2、3、4和5）参与了抓。在这两个目标中，对轻度和重度抑郁症患者的抓握控制进行了多维测量，将中重度CTS与从年龄和性别匹配的健康对照中获得的那些进行比较。拟议研究的目标与公共卫生有关，因为它们涉及一种使人衰弱的手部神经肌肉疾病，腕管综合征（CTS），影响了美国600万到1400万成年人的生活质量。我们建议使用 CTS作为一种模型，以提高我们对潜在机制的理解负责熟练的物体操作的感觉运动整合。知识通过我们提出的研究获得的信息将提供重要的洞察力，神经功能的电诊断测量涉及抓握控制的特定方面，从而改进这些临床测量的可解释性和应用。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effects of carpal tunnel syndrome on dexterous manipulation are grip type-dependent.

腕管综合征对灵巧操作的影响取决于握力类型。

DOI：
10.1371/journal.pone.0053751
发表时间：
2013
期刊：
PloS one
影响因子：
3.7
作者：
Zhang,Wei;Johnston,JamieA;Ross,MarkA;Sanniec,Kyle;Gleason,ElizabethA;Dueck,AmylouC;Santello,Marco
通讯作者：
Santello,Marco

Effects of carpal tunnel syndrome on adaptation of multi-digit forces to object mass distribution for whole-hand manipulation.