Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) renewal

减肥手术是有效的治疗极端肥胖的成年人，是最常用的第五次 十年的生活。然而，随着青少年极度肥胖的患病率增加，越来越多的 年轻人正在寻求减肥手术。关于手术体重的健康益处和风险的许多问题 青少年的损失仍然存在。2006年，青少年减肥手术纵向评估（Teen-LABS） 作为减肥手术纵向评估（LABS）的辅助研究获得了资金。青少年实验室 中心假设是，青春期的严重肥胖与医疗和 在青春期进行减肥手术可能更有效地治疗的心理社会障碍 而不是在成年后。在Teen-LABS最初的5年里，几项值得注意的成就 建立了研究基础设施，包括若干小组委员会， 入组207例受试者（截至2011年1月）-超过预期250例受试者的80%; 支持10项辅助研究和3个子研究的基础设施;以及生物标本的采集和储存 (DNA血清、血浆、尿液）。数据协调中心（DCC） 迄今已建立了一个研究基础设施和数据库的特点是标准化和严格的 数据收集、数据准确性和完整性。青少年实验室五人研究的首要目标 一年的更新期将侧重于完成青少年实验室方案的既定目标，此外， 其他几个新的科学研究领域随着这一扩展，DCC的核心职能将是 继续支持联合会的流程和调查人员，重点关注核心职责，包括： 数据收集和管理、统计分析和报告、实验室和储存库样品 跟踪、研究出版物合作、研究会议协调、研究人员培训和认证。 IRB和NIH报告要求、研究中心稽查和监查、数据库质量保证、协调 并支持所有研究委员会职能、DSMB和指导委员会会议协调，以及 知情同意跟踪。

Bariatric surgery is effective in treating extreme obesity in adults, and is most commonly used in the 5th decade of life. However, as the prevalence of extreme obesity in adolescence increases, more and more youth are seeking bariatric surgery. Many questions regarding the health benefits and risks of surgical weight loss in adolescents still remain. In 2006, Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) was awarded funds as an ancillary study to Longitudinal Assessment of Bariatric Surgery (LABS). The TeenLABS central hypothesis was that severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with bariatric surgery during adolescence rather than later in adulthood. During the initial 5 years of Teen-LABS, several noteworthy achievements were accomplished: establishment of a research infrastructure, including several sub-committees and work groups; enrollment of 207 subjects (through January 2011) - over 80% of the desired 250 subjects; infrastructure supporting 10 ancillary studies and 3 sub-studies; and collection and storage of biospecimens (DNA, serum, plasma, urine) in the NIDDK-Biospecimen Repository. The Data Coordinating Center (DCC) thus far has established a research infrastructure and database characterized by standardized and rigorous data collection, data accuracy, and completeness. The overarching goals ofthe Teen LABS study forthe five year renewal period will focus on the completion of stated goals ofthe Teen LABS protocol, in addition to several other new areas of scientific investigation. With this extension, the core functions of DCC will be to continue support of Consortium processes and investigators by focusing on core responsibilities including: data collection and management, statistical analysis and reporting, laboratory and repository sample tracking, partnership in study publications, coordination of study meetings, study staff training & certification. IRB and NIH reporting requirements, site auditing and monitoring, database quality assurance, coordination and support of all study committee functions, DSMB and Steering Committee meeting coordination, and informed consent tracking.