Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) renewal

青少年减肥手术纵向评估 (Teen-LABS) 更新

• 批准号: 8337730
• 负责人: Charles Ralph Buncher
• 金额: $ 85.89万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8337730
• 关键词: Achievement; Address; Adolescence; Adolescent; Adult; Ancillary Study; Area; Award; Benefits and Risks; Body Weight decreased; Certification; Clinical Trials Data Monitoring Committees; Collection; Communication; Confidentiality; DNA; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Quality; Data Reporting; Databases; Development; Enrollment; Ensure; Funding; Goals; Health Benefit; Impairment; Informed Consent; Institutional Review Boards; Investigation; Laboratories; Lead; Leadership; Life; Maintenance; Manuscripts; Measures; Medical; Monitor; Morbid Obesity; National Institute of Diabetes and Digestive and Kidney Diseases; Operative Surgical Procedures; Plasma; Preparation; Prevalence; Procedures; Process; Protocols documentation; Publications; Publishing; Reporting; Research; Research Infrastructure; Research Personnel; Safety; Sample Size; Sampling; Site; System; Teenagers; Testing; Training; United States National Institutes of Health; Urine; Validation; Youth; bariatric surgery; data management; design; follow-up; meetings; obesity treatment; psychosocial; quality assurance; repository; working group

Bariatric surgery is effective in treating extreme obesity in adults, and is most commonly used in the 5th decade of life. However, as the prevalence of extreme obesity in adolescence increases, more and more youth are seeking bariatric surgery. Many questions regarding the health benefits and risks of surgical weight loss in adolescents still remain. In 2006, Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) was awarded funds as an ancillary study to Longitudinal Assessment of Bariatric Surgery (LABS). The TeenLABS central hypothesis was that severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with bariatric surgery during adolescence rather than later in adulthood. During the initial 5 years of Teen-LABS, several noteworthy achievements were accomplished: establishment of a research infrastructure, including several sub-committees and work groups; enrollment of 207 subjects (through January 2011) - over 80% of the desired 250 subjects; infrastructure supporting 10 ancillary studies and 3 sub-studies; and collection and storage of biospecimens (DNA, serum, plasma, urine) in the NIDDK-Biospecimen Repository. The Data Coordinating Center (DCC) thus far has established a research infrastructure and database characterized by standardized and rigorous data collection, data accuracy, and completeness. The overarching goals ofthe Teen LABS study forthe five year renewal period will focus on the completion of stated goals ofthe Teen LABS protocol, in addition to several other new areas of scientific investigation. With this extension, the core functions of DCC will be to continue support of Consortium processes and investigators by focusing on core responsibilities including: data collection and management, statistical analysis and reporting, laboratory and repository sample tracking, partnership in study publications, coordination of study meetings, study staff training & certification. IRB and NIH reporting requirements, site auditing and monitoring, database quality assurance, coordination and support of all study committee functions, DSMB and Steering Committee meeting coordination, and informed consent tracking.

减肥手术是治疗成人极度肥胖的有效方法，在第五世纪最常用