Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) renewal

减肥手术在治疗成人极端肥胖症方面是有效的，并且在5岁以下最常用 十年的生命。然而，随着青少年极端肥胖患病率的增加，越来越多的 年轻人正在寻求减肥手术。关于外科手术体重的健康益处和风险的许多问题 青少年中的失落现象依然存在。2006年青少年减肥手术纵向评估(青少年实验室) 作为减肥手术纵向评估(LABS)的辅助研究获得资助。青少年实验室 中心假设是青春期的严重肥胖与医学和 青春期减肥手术可能更有效治疗的心理社会障碍 而不是在成年以后。在青少年实验室的最初5年中，有几项值得注意的成就 已完成：建立研究基础设施，包括几个小组委员会和工作 团体；207名受试者入学(至2011年1月)--超过所需250名受试者的80%； 支持10项辅助研究和3项次级研究的基础设施；以及生物杀虫剂的收集和储存 (DNA、血清、血浆、尿液)保存在NIDDK-Biospecimen库中。数据协调中心(DCC) 到目前为止，已经建立了以规范和严谨为特点的研究基础设施和数据库 数据收集、数据准确性和完整性。五人青少年实验室研究的首要目标 一年的续约期将侧重于完成青少年实验室协议规定的目标，此外 科学调查的其他几个新领域。有了这个扩展，DCC的核心功能将是 继续支持财团进程和调查人员，重点放在核心责任上，包括： 数据收集和管理、统计分析和报告、实验室和储存库样本 跟踪、合作研究出版物、协调研究会议、研究人员培训和认证。 IRB和NIH报告要求、现场审计和监控、数据库质量保证、协调 和支持所有研究委员会的职能，战略与预算办公室和指导委员会会议的协调，以及 知情同意跟踪。

Bariatric surgery is effective in treating extreme obesity in adults, and is most commonly used in the 5th decade of life. However, as the prevalence of extreme obesity in adolescence increases, more and more youth are seeking bariatric surgery. Many questions regarding the health benefits and risks of surgical weight loss in adolescents still remain. In 2006, Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) was awarded funds as an ancillary study to Longitudinal Assessment of Bariatric Surgery (LABS). The TeenLABS central hypothesis was that severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with bariatric surgery during adolescence rather than later in adulthood. During the initial 5 years of Teen-LABS, several noteworthy achievements were accomplished: establishment of a research infrastructure, including several sub-committees and work groups; enrollment of 207 subjects (through January 2011) - over 80% of the desired 250 subjects; infrastructure supporting 10 ancillary studies and 3 sub-studies; and collection and storage of biospecimens (DNA, serum, plasma, urine) in the NIDDK-Biospecimen Repository. The Data Coordinating Center (DCC) thus far has established a research infrastructure and database characterized by standardized and rigorous data collection, data accuracy, and completeness. The overarching goals ofthe Teen LABS study forthe five year renewal period will focus on the completion of stated goals ofthe Teen LABS protocol, in addition to several other new areas of scientific investigation. With this extension, the core functions of DCC will be to continue support of Consortium processes and investigators by focusing on core responsibilities including: data collection and management, statistical analysis and reporting, laboratory and repository sample tracking, partnership in study publications, coordination of study meetings, study staff training & certification. IRB and NIH reporting requirements, site auditing and monitoring, database quality assurance, coordination and support of all study committee functions, DSMB and Steering Committee meeting coordination, and informed consent tracking.