Nanotechnology for Minimally Invasive Cancer Detection and Resection

用于微创癌症检测和切除的纳米技术

• 批准号: 8413972
• 负责人: Aaron M. Mohs
• 金额: $ 24.89万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8413972
• 关键词: Address; Animal Model; Animals; Artificial nanoparticles; Award; Benign; Biomedical Engineering; Caliber; Cancer Center; Cancer Detection; Cancer Patient; Cancerous; Canis familiaris; Clinical; Computers and Advanced Instrumentation; Contrast Media; Detection; Development; Devices; Diagnostic; Disease; Doctor of Medicine; Doctor of Philosophy; Drug Kinetics; Endoscopes; Endoscopy; Engineering; Environment; Excision; FDA approved; Faculty; Feedback; Fiber Optics; Fluorescence; Fluorescent Dyes; Foundations; Goals; Hemorrhage; Image; Indocyanine Green; Injury; Institution; International; K-Series Research Career Programs; Laboratory Research; Laparoscopic Surgical Procedures; Lead; Malignant - descriptor; Malignant Neoplasms; Medical; Medicine; Mentors; Mentorship; Methods; Modeling; Morbidity - disease rate; Nanotechnology; Nodule; Non-Small-Cell Lung Carcinoma; Normal tissue morphology; Operating Rooms; Operative Surgical Procedures; Optics; Pain; Pathological Staging; Pathology; Pathway interactions; Patients; Penetration; Pennsylvania; Phase; Polymers; Positioning Attribute; Primary Neoplasm; Procedures; Quality of life; Recovery; Recurrence; Recurrent tumor; Repeat Surgery; Research; Research Methodology; Research Personnel; Resected; Residual Cancers; Residual Tumors; Science; Sensitivity and Specificity; Spectrum Analysis; Surgeon; Surgical Oncology; Surgical incisions; Surgical margins; System; Techniques; Thoracic Neoplasms; Thoracic Surgical Procedures; Time; Tissues; Training; Tumor Tissue; Universities; Validation; abstracting; animal tissue; base; biocompatible polymer; biodegradable polymer; cancer surgery; career; clinical efficacy; clinically relevant; design; disability; flexibility; fluorophore; high risk; improved; innovation; instrumentation; intraoperative imaging; meetings; miniaturize; minimally invasive; mortality; nano; nanoparticle; nanoprobe; neoplastic cell; optical fiber; physical property; programs; self assembly; tumor

NANOTECHNOLOGY FOR MINIMALLY INVASIVE CANCER DETECTION AND RESECTION Project Abstract Effective surgical resection of tumors is the most important predictor for cancer patient survival. Although surgery is curative in approximately 45% of cancer patients, up to 40% of patients have recurrent tumors due to undetectable differences between malignant and benign hyperplasic or normal tissue, leading to incomplete resection of cancerous tissue. In addition, patients that undergo surgery often suffer a decreased quality of life due to injury associated with the surgery. The primary goal of this Pathway to Independence Award in Cancer Nanotechnology Research (K99/R00) proposal is to integrate the unique capabilities of nanotechnology with innovative optical instrumentation to improve detection and resection of malignant tissue through minimally invasive surgery. This challenge will be addressed by combining expertise and research methodology in nanotechnology, instrumentation, and surgical oncology. This career development award has four specific aims: (1) develop biodegradable and nontoxic activatable fluorescence nanoparticle probes; (2) develop a miniaturized and flexible device for intraoperative fluorescence detection; (3) integrate the miniaturized, flexible optical device with endoscopy for minimally invasive detection of tumors; and (4) evaluate the spectral endoscope using spontaneous thoracic tumors in large animals (canines) during surgery to improve disease clearance and pathological staging. Accomplishing these specific aims will utilize targeted and activatable nanoparticles to increase specific localization of the probes in cancerous tissue. Detecting and resecting cancerous tissue via the fiber optic endoscopic imaging system will decrease the rate of tumor recurrence by more accurately detecting surgical margins and residual cancer and reduce surgery associated morbidity, such as decreasing patient pain, discomfort, and disability. My immediate career goal is to obtain a tenure-track faculty position that focuses on integrating nanotechnology with surgical oncology. Long-term, I would like to lead a research program at the interface of science, medicine, and engineering and expand the number and types of diseases that will be investigated. Ideally this research would be performed at an institution where I can be involved with academic and medical investigators from diverse fields. Training during the mentored phase of this award will focus on several key aspects to facilitate my development to achieve these goals as an independent investigator, including (1) providing the candidate with a strong foundation in optical nanoparticle engineering, (2) instrumentation for fiber optic based spectral and near-infrared imaging, and (3) methodological challenges to minimally invasive laparoscopic procedures in surgical oncology. Training will take place in the Emory-Georgia Tech Biomedical Engineering Department under the mentorship of Dr. Shuming Nie, Ph.D., an international expert in nanotechnology and director of the Emory-Georgia Tech Center for Cancer Nanotechnology Excellence, and at the University of Pennsylvania under the co-mentorship of Dr. Sunil Singhal, M.D., Director of the Thoracic Surgery Research Laboratory and Chief of Thoracic Surgery. The environment at these two institutions is ideal for this project because I will have full access to the most advanced instrumentation for nanoparticle design, synthesis, and characterization; I will benefit from instrumentation engineers with fabrication facilities to meet my needs; and a highly collaborative translational environment, which is paramount for successful development of this project that integrates nanotechnology with minimally invasive intraoperative instrumentation. In addition, the collaborative training will be supplemented by formal coursework at Emory and Georgia Tech in optics and instrumentation.

纳米技术用于微创癌症检测和切除 项目摘要 肿瘤的有效手术切除是癌症患者生存的最重要预测因素。虽然 手术在大约45%的癌症患者中是治愈性的，高达40%的患者由于肿瘤复发， 恶性和良性增生或正常组织之间无法检测到的差异，导致不完全的 切除癌组织。此外，接受手术的患者通常会遭受生活质量下降 因为手术造成的损伤这个癌症独立之路奖的主要目标 纳米技术研究（K99/R 00）的建议是整合纳米技术的独特功能， 创新的光学仪器，通过最低限度地提高恶性组织的检测和切除 侵入性手术这一挑战将通过将专业知识和研究方法相结合来解决， 纳米技术、仪器和外科肿瘤学。该职业发展奖有四个具体的 目的：（1）开发可生物降解、无毒、可活化的荧光纳米粒子探针;（2）开发一种 用于术中荧光检测的小型化和柔性装置;（3）将小型化、柔性 用于肿瘤的微创检测的内窥镜光学装置;和（4）评估光谱 内窥镜在手术过程中使用大型动物（犬）的自发性胸部肿瘤以改善疾病 清除率和病理分期。实现这些具体目标将利用有针对性的和可激活的 纳米颗粒以增加探针在癌组织中的特异性定位。探测和切除 通过光纤内窥镜成像系统对癌组织进行成像将降低肿瘤复发率 通过更准确地检测手术切缘和残余癌， 发病率，例如减少患者疼痛、不适和残疾。我近期的职业目标是获得 终身教职，专注于将纳米技术与外科肿瘤学相结合。从长远来看，我 我想在科学，医学和工程的界面上领导一个研究项目，并扩大 将调查的疾病的数量和类型。理想情况下，这项研究将在一个 在这里，我可以与来自不同领域的学术和医学研究人员接触。锻炼 该奖项的指导阶段将集中在几个关键方面，以促进我的发展，以实现 这些目标作为一个独立的调查员，包括（1）为候选人提供一个坚实的基础， 光学纳米粒子工程，（2）用于基于光纤的光谱和近红外成像的仪器， 以及（3）外科肿瘤学中微创腹腔镜手术的方法学挑战。 培训将在埃默里-佐治亚理工学院生物医学工程系进行， 聂树明博士他是一位国际纳米技术专家，也是埃默里-乔治亚理工学院的主任， 癌症纳米技术卓越中心，并在宾夕法尼亚大学的共同导师 医学博士苏尼尔·辛格哈尔胸外科研究实验室主任兼胸外科主任 手术这两个机构的环境非常适合这个项目，因为我可以完全访问 最先进的纳米粒子设计，合成和表征仪器;我将受益于 仪器工程师与制造设施，以满足我的需求;和一个高度合作的翻译 环境，这是至关重要的成功开发这个项目，集成纳米技术 微创手术器械此外，合作培训将 在埃默里大学和格鲁吉亚理工学院学习光学和仪器，并辅以正式的课程。