NIAMS Multidisciplinary Clinical Research Center

达特茅斯大学肌肉骨骼疾病多学科临床研究中心（MCRC）致力于通过重点研究合作和不同学科之间的跨学科教育计划来促进严格的临床研究。这些学科包括整形外科、医学、老年病学、生物统计学、卫生服务研究、决策科学、卫生经济学、信息学和流行病学，这些学科对于实现MCRC改善肌肉骨骼疾病患者的卫生保健质量和健康的目标至关重要。基础设施和方法专业知识的增长与niams赞助的脊柱患者预后研究试验（SPORT）相结合，再加上对比较有效性研究的大量机构投资，使达特茅斯大学的MCRC得到了进一步发展的良机。以完善的方法论核心为基础，利用和补充新的机构资源，扩大研究基地，提供全面的方法和行政支持。MCRC计划开展三个整体项目：项目1将在全国具有代表性的患有髋关节或其他骨质疏松相关骨折的老年人人群中开展二级骨折预防的比较有效性研究。项目2将开发、验证和评估一种新的基于网络的治疗结果计算器，用于交流个性化的风险和收益信息，以帮助外科医生、初级保健医生和面临与背痛相关疾病的手术相关的复杂决策的患者。项目3（发展中）将探索基于声明的方法的有效性，以确定手术并发症，并开发一种新的基于声明的安全监测方法，使用生物制剂骨形态发生蛋白（BMP）作为案例研究。通过方法论核心，将为正在接受培训的临床医生和研究人员提供新的教育机会，从而促进新的临床研究举措，进一步改善肌肉骨骼疾病患者的健康。

The Multidisciplinary Clinical Research Center (MCRC) in Musculoskeletal Diseases at Dartmouth is committed to promoting rigorous clinical research through focused research collaborations and cross-disciplinary educational initiatives among diverse disciplines. These disciplines include orthopedic surgery, medicine, geriatrics, biostatistics, health services research, decision sciences, health economics, informatics and epidemiology, which all are critical for meeting the MCRC's objective of improving the health care quality and health for patients suffering from musculoskeletal diseases. The growth in infrastructure and methodological expertise associated with the NIAMS-sponsored Spine Patient Outcomes Research Trial (SPORT) has combined with large institutional investments in comparative effectiveness research to make this an opportune time to further develop the MCRC at Dartmouth. Based on a well-developed Methodology Core leveraging and complementing new institutional resources, an expanded research base will be provided with comprehensive methodological and administrative support. Three integral projects are planned within the MCRC: Project 1 will conduct comparative effectiveness research focused on secondary fracture prevention in a nationally-representative population of elders who have sustained a hip or other osteoporosis-related fracture. Project 2 will develop, validate, and evaluate a novel web-based treatment outcomes calculator for communicating individualized risk and benefit information to aid surgeons, primary care physicians and patients facing complex decisions related to surgery for back-pain related conditions. Project 3 (developmental) will explore the validity of claims-based methods to ascertain complications of surgery and develop a novel claims-based approach to safety surveillance using the biological agent Bone Morphogenetic Protein (BMP) as a case study. Through the Methodology Core, new educational opportunities will be provided for clinicians and researchers in training, thereby fostering new clinical research initiatives that will further improve the health of patients with musculoskeletal disease.