NIAMS Multidisciplinary Clinical Research Center

达特茅斯的肌肉骨骼疾病多学科临床研究中心（MCRC）致力于通过集中的研究合作和不同学科之间的跨学科教育计划来促进严格的临床研究。这些学科包括整形外科、医学、老年病学、生物统计学、卫生服务研究、决策科学、卫生经济学、信息学和流行病学，这些学科对实现MCRC改善医疗保健质量和肌肉骨骼疾病患者健康的目标至关重要。与NIAMS赞助的脊柱患者结局研究试验（SPORT）相关的基础设施和方法学专业知识的增长与比较有效性研究的大型机构投资相结合，使其成为进一步发展达特茅斯MCRC的有利时机。在一个充分发展的核心方法的基础上，利用和补充新的机构资源，将为扩大的研究基础提供全面的方法和行政支助。在MCRC内计划了三个综合项目：项目1将进行比较有效性研究，重点是在全国有代表性的髋部骨折或其他骨质疏松相关骨折的老年人中进行二级骨折预防。项目2将开发，验证和评估一种新型的基于网络的治疗结果计算器，用于传达个性化的风险和受益信息，以帮助外科医生，初级保健医生和面临与背痛相关疾病手术相关的复杂决策的患者。项目3（开发）将探索基于索赔的方法的有效性，以确定手术并发症，并开发一种新的基于索赔的方法，以生物制剂骨形态发生蛋白（BMP）作为案例研究的安全性监测。通过方法学核心，将为临床医生和研究人员提供新的教育机会，从而促进新的临床研究计划，进一步改善肌肉骨骼疾病患者的健康。

The Multidisciplinary Clinical Research Center (MCRC) in Musculoskeletal Diseases at Dartmouth is committed to promoting rigorous clinical research through focused research collaborations and cross-disciplinary educational initiatives among diverse disciplines. These disciplines include orthopedic surgery, medicine, geriatrics, biostatistics, health services research, decision sciences, health economics, informatics and epidemiology, which all are critical for meeting the MCRC's objective of improving the health care quality and health for patients suffering from musculoskeletal diseases. The growth in infrastructure and methodological expertise associated with the NIAMS-sponsored Spine Patient Outcomes Research Trial (SPORT) has combined with large institutional investments in comparative effectiveness research to make this an opportune time to further develop the MCRC at Dartmouth. Based on a well-developed Methodology Core leveraging and complementing new institutional resources, an expanded research base will be provided with comprehensive methodological and administrative support. Three integral projects are planned within the MCRC: Project 1 will conduct comparative effectiveness research focused on secondary fracture prevention in a nationally-representative population of elders who have sustained a hip or other osteoporosis-related fracture. Project 2 will develop, validate, and evaluate a novel web-based treatment outcomes calculator for communicating individualized risk and benefit information to aid surgeons, primary care physicians and patients facing complex decisions related to surgery for back-pain related conditions. Project 3 (developmental) will explore the validity of claims-based methods to ascertain complications of surgery and develop a novel claims-based approach to safety surveillance using the biological agent Bone Morphogenetic Protein (BMP) as a case study. Through the Methodology Core, new educational opportunities will be provided for clinicians and researchers in training, thereby fostering new clinical research initiatives that will further improve the health of patients with musculoskeletal disease.