Exercise and Body Composition in Juvenile Idiopathic Arthritis.

描述(申请人提供)：幼年特发性关节炎(JIA)是儿童最常见的慢性风湿病。受影响的儿童会感到疲劳、疼痛、压痛和关节活动能力丧失。JIA、缺乏运动和用于治疗JIA的药物结合在一起，往往会导致肌肉和骨骼的丧失，这可能会导致其他严重的健康问题，并导致长期残疾。因此，找到保存JIA儿童身体成分的方法是至关重要的。有氧运动经常被推荐给JIA，但研究并不确定 福利条款。对患有类风湿性关节炎(一种类似于JIA的疾病)的成年人的研究表明，抗阻运动可以改善力量、功能能力、症状，甚至可能有助于改善疾病本身。JIA对阻力练习的研究尚未见报道。因此，我们将检验家庭有氧运动和阻力运动对身体成分、肌肉力量、关节柔韧性和活动范围、有氧能力、疼痛、疲劳、功能能力、生活质量、疾病活动性和炎症的影响。我们假设，与那些做有氧运动的孩子相比，做阻力运动的孩子在这些指标上会有更大的进步。44名10-18岁的JIA患者将参加这项为期12周的研究。这项研究将增进我们对运动疗法治疗JIA的影响的了解，尤其重要，因为拟议的家庭计划是可行的，并有可能显着改善JIA儿童的生活。 公共卫生相关性：青少年特发性关节炎(JIA)是一种痛苦的疾病，与大量肌肉和骨骼丢失有关，使儿童难以过上完整和积极的生活。本研究将从肌肉、骨骼、力量、症状、生活质量和生物学参数等方面评价监督阻力运动训练对JIA患儿的安全性和有效性。

DESCRIPTION (provided by applicant): Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in children. Affected children suffer from fatigue, pain, tenderness, and loss of mobility of their joints. The combination of JIA, physical inactivity, and the drugs used to treat JIA, often produce muscle and bone loss which can lead to other serious health problems and to long-term disability. So finding ways to preserve body composition in children with JIA is vital. Aerobic exercise is often recommended for JIA but, studies are not definitive in terms of benefit. Studies of adults with rheumatoid arthritis, a disease similar to JIA, show that resistance exercise can improve strength, functional capacity, symptoms, and may even help to improve the disease itself. Resistance exercise has never been studied in JIA. Therefore, we will examine the effects of home-based aerobic versus resistance exercise on measures of body composition, muscle strength, flexibility and range of motion of joints, aerobic capacity, pain, fatigue, functional capacity, quality of life, disease activity, and inflammation. We hypothesize that the children who do resistance exercise will improve more on these measures compared to those who do aerobic exercise. Forty-four JIA patients, ages 10-18 years old, will take part in this 12-week study. This study will advance our knowledge of the effects of exercise therapy for JIA and will be of particular importance since the proposed home-based program is feasible and has the potential to markedly improve the lives of children with JIA. PUBLIC HEALTH RELEVANCE: Juvenile idiopathic arthritis (JIA) is a painful disease that is associated with substantial muscle and bone loss making it difficult for children to lead full and active lives. This study will evaluate the safety and effectiveness of supervised resistance exercise training in children with JIA on muscle, bone, strength, symptoms, quality of life and biological parameters.