Exercise and Body Composition in Juvenile Idiopathic Arthritis.

幼年特发性关节炎的运动和身体成分。

• 批准号: 8383930
• 负责人: SANGEETA DILEEP SULE
• 金额: $ 17.01万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8383930
• 关键词: 18 year old; Activities of Daily Living; Adherence; Adult; Aerobic; Aerobic Exercise; Affect; Age; American; Area; Arthralgia; Arthritis; Articular Range of Motion; Autoimmune Diseases; Biological; Body Composition; Bone Density; Child; Childhood; Chronic; Chronic Childhood Arthritis; Clinical; Clinical Research; Confidence Intervals; Data; Dermatomyositis; Disease; Disease-Modifying Second-Line Drugs; Drug usage; Effectiveness; Exercise; Fatigue; Fatty acid glycerol esters; Grant; Growth; Health; Home environment; Idiopathic Inflammatory Myopathies; Impairment; Inflammation; Inflammatory; Intervention; Investigation; Joints; Knowledge; Lead; Measures; Monitor; Muscle; Musculoskeletal; Musculoskeletal Diseases; NIH Program Announcements; Natural History; Outcome; Pain; Participant; Patients; Pharmaceutical Preparations; Physical therapy exercises; Pilot Projects; Prevalence; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Research; Research Project Grants; Resistance; Rheumatism; Rheumatoid Arthritis; Rheumatology; Role; Safety; Symptoms; Testing; Training; Weight-Bearing state; base; bone; bone loss; bone strength; college; combat; disability; experience; flexibility; functional decline; improved; inflammatory marker; innovation; insight; interest; muscle form; muscle strength; novel; primary outcome; programs; response; secondary outcome; skin disorder

DESCRIPTION (provided by applicant): Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in children. Affected children suffer from fatigue, pain, tenderness, and loss of mobility of their joints. The combination of JIA, physical inactivity, and the drugs used to treat JIA, often produce muscle and bone loss which can lead to other serious health problems and to long-term disability. So finding ways to preserve body composition in children with JIA is vital. Aerobic exercise is often recommended for JIA but, studies are not definitive in terms of benefit. Studies of adults with rheumatoid arthritis, a disease similar to JIA, show that resistance exercise can improve strength, functional capacity, symptoms, and may even help to improve the disease itself. Resistance exercise has never been studied in JIA. Therefore, we will examine the effects of home-based aerobic versus resistance exercise on measures of body composition, muscle strength, flexibility and range of motion of joints, aerobic capacity, pain, fatigue, functional capacity, quality of life, disease activity, and inflammation. We hypothesize that the children who do resistance exercise will improve more on these measures compared to those who do aerobic exercise. Forty-four JIA patients, ages 10-18 years old, will take part in this 12-week study. This study will advance our knowledge of the effects of exercise therapy for JIA and will be of particular importance since the proposed home-based program is feasible and has the potential to markedly improve the lives of children with JIA. PUBLIC HEALTH RELEVANCE: Juvenile idiopathic arthritis (JIA) is a painful disease that is associated with substantial muscle and bone loss making it difficult for children to lead full and active lives. This study will evaluate the safety and effectiveness of supervised resistance exercise training in children with JIA on muscle, bone, strength, symptoms, quality of life and biological parameters.

描述（由申请人提供）：幼年特发性关节炎（JIA）是儿童中最常见的慢性风湿性疾病。受影响的儿童遭受疲劳，疼痛，压痛和关节活动性丧失。JIA、缺乏身体活动和用于治疗JIA的药物的结合，通常会导致肌肉和骨骼损失，这可能导致其他严重的健康问题和长期残疾。因此，找到保护JIA儿童身体成分的方法至关重要。有氧运动通常被推荐用于JIA，但研究并不确定， 利益的条款。对患有类风湿性关节炎（一种类似于JIA的疾病）的成年人的研究表明，阻力运动可以改善力量，功能能力，症状，甚至可能有助于改善疾病本身。抗阻运动在JIA中从未被研究过。因此，我们将研究家庭有氧运动与阻力运动对身体成分、肌肉力量、关节灵活性和运动范围、有氧能力、疼痛、疲劳、功能能力、生活质量、疾病活动和炎症的影响。我们假设，与那些做有氧运动的孩子相比，做抗阻运动的孩子在这些指标上会有更大的改善。44名10-18岁的JIA患者将参加这项为期12周的研究。这项研究将推进我们对运动疗法对JIA影响的认识，并且将具有特别重要的意义，因为拟议的家庭计划是可行的，并且有可能显着改善JIA儿童的生活。 公共卫生关系：幼年特发性关节炎（JIA）是一种疼痛的疾病，与大量的肌肉和骨骼损失有关，使儿童难以过上充实和积极的生活。本研究将评估有监督的抗阻运动训练对JIA儿童肌肉、骨骼、力量、症状、生活质量和生物学参数的安全性和有效性。