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Regenerative Medicine in Rehabilitation

康复中的再生医学

基本信息

批准号：
8398344
负责人：
Samuel Richard Ward
金额：
$ 1.2万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-15 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8398344
关键词：
American Physical Therapy Association Applied Research Area Basic Science Biology Biomechanics Biomedical Engineering Cells Clinical Research Clinical Sciences Collaborations Commit Development Discipline Environment Explosion Foundations Functional disorder Future Grant Health Health Policy Human Interdisciplinary Study Intervention Investigation Kinesiology Knowledge Lead Life Methodology Molecular Movement Natural regeneration Pathology Patients Physiological Physiology Regenerative Medicine Rehabilitation Research Rehabilitation therapy Research Research Personnel Science Scientific Advances and Accomplishments Scientist Time Tissues Translational Research Work clinical practice design improved innovation insight interest meetings neuromusculoskeletal posters programs regenerative skills stem cell biology symposium tissue regeneration

项目摘要

DESCRIPTION (provided by applicant): Regenerative medicine is a field dedicated to replacing or regenerating living tissues to restore normal function. Although the fundamental concepts have been used to treat a limited set of conditions for many years, there has been an explosion of interest in the area because of recent developments in stem cell biology. Currently, molecular, cell, and developmental biologists are leaders in the field because the state-of-the-art science is directed at manipulating cell fate and enhancing regenerative capacity. However, recent work has suggested that the biomechanical and physiological environment of these cells is pivotal to their ultimate differentiation, health, and function. For that reason, bioengineeringis an emerging discipline within regenerative medicine. Clinically, rehabilitation professionals use similar skills to integrate biology, biomechanics, and physiology in a way that allows the timing and intensity of physical interventions to be optimized for tissue regeneration and ultimately, patient function. Given the long-term trajectory of regenerative medicine and the recent integration with rehabilitation, this is an ideal time for rehabilitation clinicians and scientists bioengineers, and cell and developmental biologists to coordinate their efforts to move the field forward. Here the PIs propose an open and interactive, Gordon-style conference on regenerative medicine and rehabilitation with speakers who are leaders in the field and across these different disciplines. The primary objectives of the of the conference are to: 1) accelerate the understanding of regenerative medicine approaches across the spectrum of neuromusculoskeletal pathologies amongst rehabilitation professionals and 2) accelerate productive collaborations between established investigators in regenerative medicine and rehabilitation. The first objective will be met through the conference didactics. The latter objective will be met by providing adequate opportunities for conference attendees to interact and through a targeted, meeting-specific pilot grant program designed to accelerate research opportunities amongst newly established collaborations. PUBLIC HEALTH RELEVANCE: Given the long-term trajectory of regenerative medicine, rehabilitation clinicians and scientists need to become involved in this discipline. They have the skills to manipulate biomechanics and physiology in a way that optimizes the timing and intensity of physical interventions to maximize tissue regeneration and ultimately, patient function.

描述（由申请人提供）：再生医学是一个致力于替换或再生活组织以恢复正常功能的领域。虽然基本概念已被用于治疗有限的条件多年，有一个爆炸的兴趣，因为在该地区的干细胞生物学的最新发展。目前，分子，细胞和发育生物学家是该领域的领导者，因为最先进的科学的目标是操纵细胞命运和增强再生能力。然而，最近的研究表明，这些细胞的生物力学和生理环境对其最终分化，健康和功能至关重要。因此，生物工程是再生医学中的一门新兴学科。在临床上，康复专业人员使用类似的技能来整合生物学，生物力学和生理学，以使物理干预的时间和强度能够优化组织再生并最终优化患者功能。鉴于再生医学的长期发展轨迹以及最近与康复的整合，这是康复临床医生和科学家生物工程师以及细胞和发育生物学家协调努力以推动该领域向前发展的理想时机。在这里，PI提出了一个开放和互动的，戈登式的再生医学和康复会议，演讲者是该领域和这些不同学科的领导者。会议的主要目标是：1）加速康复专业人员对神经肌肉骨骼病理学领域再生医学方法的理解，2）加速再生医学和康复领域既定研究人员之间的富有成效的合作。第一个目标将通过会议教学法来实现。后一个目标将通过为与会者提供充分的互动机会，并通过一个有针对性的，会议特定的试点赠款计划，旨在加快新建立的合作研究机会来实现。公共卫生相关性：鉴于再生医学的长期发展轨迹，康复临床医生和科学家需要参与这一学科。他们有能力以优化物理干预的时间和强度的方式操纵生物力学和生理学，以最大限度地促进组织再生，最终实现患者功能。