T2 Relaxation Time of Knee Cartilage in the OAI Incidence Subcohort

OAI 发病亚组中膝关节软骨的 T2 松弛时间

• 批准号: 8277980
• 负责人: THOMAS M LINK
• 金额: $ 15.97万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8277980
• 关键词: Age; Anatomy; Biological Markers; Body mass index; Bone Density; Bone Marrow; Cartilage; Cartilage Matrix; Clinical; Data Analyses; Degenerative polyarthritis; Development; Diagnosis; Disease; Elderly; Evolution; Heterogeneity; High Prevalence; Imaging Techniques; Incidence; Instruction; Joints; Knee; Knee Injuries; Knee Osteoarthritis; Knee joint; Knowledge; Lesion; Life Style; Link; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Measurement; Measures; Meniscus structure of joint; Methods; Organ; Outcome; Outcome Measure; Pain; Patients; Performance; Physical activity; Physical activity scale; Prevalence; Preventive; Principal Investigator; Recruitment Activity; Relaxation; Risk; Role; Staging; Symptoms; Texture; Time; Width; aged; base; clinical application; cohort; disability; improved; indexing; muscle strength; osteoporosis with pathological fracture; performance tests; prevent

DESCRIPTION (provided by applicant): This study will thoroughly investigate the potential role and significance of cartilage T2 relaxation time as a potential outcome marker for early osteoarthritis. It will focus on asymptomatic (according to WOMAC pain score) subjects of the incidence cohort of the OAI with varying degrees of physical activity, who are at increased risk for osteoarthritis. A number of these subjects will eventually develop osteoarthritis over the course of this 48 months longitudinal study and the proposed data analysis will provide unique information on the evolution of MR based biomarkers in this cohort. The specific aims are (I) to assess prevalence of cartilage, meniscal and ligamentous lesions in subjects from the incidence cohort of the OAI aged 45-60 years without pain using the whole organ magnetic resonance imaging score (WORI\/IS) in relation to physical activity determined by the physical activity scale for the elderly (RASE) and physical performance tests, (II) to measure cartilage T2 of all joint compartments combined and separately and correlate these quantitative measurements with prevalence and grade of focal cartilage, meniscal, ligamentous and bone marrow lesions as well as measurements of physical activity and physical performance, (IIIA) to analyze whether baseline T2 values will predict focal lesion progression diagnosed with H/OR/WS, clinical changes in KOOS (Knee Injury and Osteoarthritis Outcome Score) indices and eventually changes in PASE after 24 and 48 months and (IIIB) to longitudinally assess changes in T2 values, radiographic findings and focal joint lesions diagnosed with morphological MR sequences (WORMS) in relation to changes of pain scales, PASE and physical performance over a period of 48 months. The study will be performed in 300 subjects recruited from the incidence cohort of the OAI with no pain based on WOMAC scores, age 45-60 years and normal body mass index at baseline. Semiquantitative and quantitative MR imaging parameters will be analyzed in relation to clinical findings over a period of 4 years. We strongly believe, that the advances in knowledge that we gain through this study will help us better understand the role of T2 values in OA in relation to the evolution of OA and will help in focusing our preventive efforts on the earliest disease stages. This study may also provide evidence on life style factors that may be modified to prevent the development of osteoarthritis. RELEVANCE (See instructions): The combined analyses of morphological and quantitative MR imaging findings in relation to clinical findings will help us better understand the evolution of osteoarthritis at its earliest stages. Assessing cartilage matrix quality determined with T2 measurements may potentially gain a similar role in predicting risk of osteoarthritis such as bone mineral density currently has in predicting osteoporotic fractures. This longitudinal study performed in patients from the incidence cohort of the OAI will for the first time provide evidence whether cartilage T2 can predict development of OA, study MR findings associated with the evolution of OA and potentially give evidence on how long-term to prevent osteoarthritis and disability.

描述（由申请方提供）：本研究将彻底研究软骨T2弛豫时间作为早期骨关节炎潜在结局标志物的潜在作用和意义。它将重点关注OAI发病队列中具有不同程度体力活动的无症状（根据WOMAC疼痛评分）受试者，这些受试者的骨关节炎风险增加。这些受试者中的许多人最终将在48个月的纵向研究过程中发生骨关节炎，拟定的数据分析将提供该队列中基于MR的生物标志物演变的独特信息。具体目的是：（I）使用全器官磁共振成像评分评估来自年龄45-60岁无疼痛OAI发病队列的受试者中软骨、踝关节和韧带病变的患病率（WORI/IS）与由老年人体力活动量表（RASE）和体能测试确定的体力活动有关，（II）测量组合的和单独的所有关节隔室的软骨T2，并将这些定量测量与局灶性软骨、骨关节、韧带和骨髓病变的患病率和等级以及身体活动和身体表现的测量相关联，（IIIA）分析基线T2值是否可预测诊断为H/OR/WS的局灶性病变进展，KOOS的临床变化（膝关节损伤和骨关节炎结局评分）指数和24个月和48个月后PASE的最终变化，以及（IIIB）纵向评估T2值的变化，影像学检查结果和局灶性关节病变诊断的形态MR序列（蠕虫）与疼痛量表的变化，PASE和物理性能超过48个月。本研究将在300例从OAI发病队列招募的受试者中进行，这些受试者根据WOMAC评分无疼痛，年龄45-60岁，基线时体重指数正常。将分析4年内与临床结果相关的半定量和定量MR成像参数。我们坚信，我们通过这项研究获得的知识进步将有助于我们更好地了解T2值在OA中与OA演变相关的作用，并将有助于我们将预防工作集中在疾病的最早阶段。这项研究还可能提供生活方式因素的证据，这些因素可能被修改以防止骨关节炎的发展。 相关性（参见说明）：结合形态学和定量MR成像结果与临床表现的分析，将有助于我们更好地了解骨关节炎在其早期阶段的演变。通过T2测量确定的软骨基质质量评估可能在预测骨关节炎风险方面具有类似的作用，例如骨矿物质密度目前在预测骨关节炎性骨折方面具有类似的作用。这项在OAI发病队列患者中进行的纵向研究将首次提供软骨T2是否可以预测OA发展的证据，研究与OA演变相关的MR结果，并可能提供关于如何长期预防骨关节炎和残疾的证据。