T2 Relaxation Time of Knee Cartilage in the OAI Incidence Subcohort

OAI 发病亚组中膝关节软骨的 T2 松弛时间

基本信息

  • 批准号:
    8119459
  • 负责人:
  • 金额:
    $ 12.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-08-01 至 2013-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This study will thoroughly investigate the potential role and significance of cartilage T2 relaxation time as a potential outcome marker for early osteoarthritis. It will focus on asymptomatic (according to WOMAC pain score) subjects of the incidence cohort of the OAI with varying degrees of physical activity, who are at increased risk for osteoarthritis. A number of these subjects will eventually develop osteoarthritis over the course of this 48 months longitudinal study and the proposed data analysis will provide unique information on the evolution of MR based biomarkers in this cohort. The specific aims are (I) to assess prevalence of cartilage, meniscal and ligamentous lesions in subjects from the incidence cohort of the OAI aged 45-60 years without pain using the whole organ magnetic resonance imaging score (WORI\/IS) in relation to physical activity determined by the physical activity scale for the elderly (RASE) and physical performance tests, (II) to measure cartilage T2 of all joint compartments combined and separately and correlate these quantitative measurements with prevalence and grade of focal cartilage, meniscal, ligamentous and bone marrow lesions as well as measurements of physical activity and physical performance, (IIIA) to analyze whether baseline T2 values will predict focal lesion progression diagnosed with H/OR/WS, clinical changes in KOOS (Knee Injury and Osteoarthritis Outcome Score) indices and eventually changes in PASE after 24 and 48 months and (IIIB) to longitudinally assess changes in T2 values, radiographic findings and focal joint lesions diagnosed with morphological MR sequences (WORMS) in relation to changes of pain scales, PASE and physical performance over a period of 48 months. The study will be performed in 300 subjects recruited from the incidence cohort of the OAI with no pain based on WOMAC scores, age 45-60 years and normal body mass index at baseline. Semiquantitative and quantitative MR imaging parameters will be analyzed in relation to clinical findings over a period of 4 years. We strongly believe, that the advances in knowledge that we gain through this study will help us better understand the role of T2 values in OA in relation to the evolution of OA and will help in focusing our preventive efforts on the earliest disease stages. This study may also provide evidence on life style factors that may be modified to prevent the development of osteoarthritis. RELEVANCE (See instructions): The combined analyses of morphological and quantitative MR imaging findings in relation to clinical findings will help us better understand the evolution of osteoarthritis at its earliest stages. Assessing cartilage matrix quality determined with T2 measurements may potentially gain a similar role in predicting risk of osteoarthritis such as bone mineral density currently has in predicting osteoporotic fractures. This longitudinal study performed in patients from the incidence cohort of the OAI will for the first time provide evidence whether cartilage T2 can predict development of OA, study MR findings associated with the evolution of OA and potentially give evidence on how long-term to prevent osteoarthritis and disability.
描述(申请人提供):这项研究将彻底调查软骨T2松弛时间作为早期骨关节炎潜在预后标志的潜在作用和意义。它将专注于OAI发病队列中无症状(根据WOMAC疼痛评分)、有不同程度体力活动的受试者,他们患骨关节炎的风险增加。在这项48个月的纵向研究中,许多受试者最终将发展为骨关节炎,拟议的数据分析将提供关于这一队列中基于MR的生物标记物演变的独特信息。具体目的是(I)使用由老年人体力活动量表(RASE)和体能测试确定的与体力活动相关的全身磁共振成像评分(WORI/IS)来评估45-60岁无痛OAI发病率队列中受试者的软骨、半月板和韧带损伤的患病率,(Ii)联合和单独测量所有关节间隙的软骨T2,并将这些定量测量与局灶性软骨、半月板、韧带和骨髓损伤的患病率和分级以及体力活动和体能的测量相关联,(IIIA)分析基线T2值是否将预测被诊断为H/OR/WS的局部病变进展、KOOS(膝关节损伤和骨关节炎结果评分)指数的临床变化以及24个月和48个月后PASE的最终变化,以及(IIIB)纵向评估T2值、放射学结果和通过形态MR序列(WORMS)诊断的局部关节病变在48个月期间的变化与疼痛分级、PASE和体能表现的关系。这项研究将在300名受试者中进行,这些受试者来自没有疼痛的OAI发病率队列,基于WOMAC评分,年龄45-60岁和基线时的正常体重指数。半定量和定量的磁共振成像参数将在4年的时间内与临床结果进行分析。我们坚信,我们通过这项研究获得的知识进步将有助于我们更好地理解骨性关节炎中T2值与骨性关节炎演变的关系,并将有助于我们将预防工作集中在疾病的早期阶段。这项研究还可能提供生活方式因素的证据,这些因素可能会被修改以防止骨关节炎的发展。 相关性(参见说明):结合形态和定量MR成像结果与临床结果进行分析,将有助于我们更好地了解骨关节炎的早期演变。通过T2测量评估软骨基质质量可能在预测骨关节炎风险方面获得类似的作用,例如骨密度目前在预测骨质疏松性骨折中所起的作用。这项从OAI发病队列中对患者进行的纵向研究将首次提供T2软骨是否可以预测OA的发展的证据,研究与OA的演变相关的MR发现,并潜在地为如何长期预防骨关节炎和残疾提供证据。

项目成果

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THOMAS M LINK其他文献

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{{ truncateString('THOMAS M LINK', 18)}}的其他基金

Impact of Weight loss on Knee Joint Biochemical and Structural Degeneration
减肥对膝关节生化和结构退化的影响
  • 批准号:
    9326817
  • 财政年份:
    2014
  • 资助金额:
    $ 12.19万
  • 项目类别:
Impact of Weight loss on Knee Joint Biochemical and Structural Degeneration
减肥对膝关节生化和结构退化的影响
  • 批准号:
    8760726
  • 财政年份:
    2014
  • 资助金额:
    $ 12.19万
  • 项目类别:
Impact of Weight loss on Knee Joint Biochemical and Structural Degeneration
减肥对膝关节生化和结构退化的影响
  • 批准号:
    9528275
  • 财政年份:
    2014
  • 资助金额:
    $ 12.19万
  • 项目类别:
T2 Relaxation Time of Knee Cartilage in the OAI Incidence Subcohort
OAI 发病亚组中膝关节软骨的 T2 松弛时间
  • 批准号:
    7924331
  • 财政年份:
    2010
  • 资助金额:
    $ 12.19万
  • 项目类别:
T2 Relaxation Time of Knee Cartilage in the OAI Incidence Subcohort
OAI 发病亚组中膝关节软骨的 T2 松弛时间
  • 批准号:
    8277980
  • 财政年份:
    2010
  • 资助金额:
    $ 12.19万
  • 项目类别:
Cortical Bone Porosity Identifies Diabetes Subjects With Fragility Fractures
皮质骨孔隙度可识别患有脆性骨折的糖尿病受试者
  • 批准号:
    7943886
  • 财政年份:
    2009
  • 资助金额:
    $ 12.19万
  • 项目类别:
Cortical Bone Porosity Identifies Diabetes Subjects With Fragility Fractures
皮质骨孔隙度可识别患有脆性骨折的糖尿病受试者
  • 批准号:
    7815422
  • 财政年份:
    2009
  • 资助金额:
    $ 12.19万
  • 项目类别:
Biomedical Imaging for Clinician Scientists
临床科学家的生物医学成像
  • 批准号:
    10464907
  • 财政年份:
    2005
  • 资助金额:
    $ 12.19万
  • 项目类别:
Biomedical Imaging for Clinician Scientists
临床科学家的生物医学成像
  • 批准号:
    8468174
  • 财政年份:
    2005
  • 资助金额:
    $ 12.19万
  • 项目类别:
Biomedical Imaging for Clinician Scientists
临床科学家的生物医学成像
  • 批准号:
    8656680
  • 财政年份:
    2005
  • 资助金额:
    $ 12.19万
  • 项目类别:

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