T2 Relaxation Time of Knee Cartilage in the OAI Incidence Subcohort

描述（由申请人提供）：本研究将深入探讨软骨T2松弛时间作为早期骨关节炎潜在结局指标的潜在作用和意义。研究将重点关注OAI发病率队列中无症状（根据WOMAC疼痛评分）的受试者，这些受试者具有不同程度的身体活动，他们患骨关节炎的风险增加。在这48个月的纵向研究过程中，这些受试者中的许多人最终会患上骨关节炎，拟议的数据分析将为该队列中基于MR的生物标志物的进化提供独特的信息。具体目的是：(I)使用全器官磁共振成像评分（WORI\/IS）与老年人体力活动量表（RASE）和体能测试确定的体力活动的关系，评估45-60岁无疼痛的OAI发病率队列中软骨、半月板和韧带病变的患病率；（II）联合或单独测量所有关节室的软骨T2，并将这些定量测量与局灶性软骨、半月板、韧带和骨髓病变的患病率和分级以及体力活动和体力表现的测量相关联；（IIIA）分析基线T2值是否可以预测诊断为H/OR/WS的局灶性病变进展；在24个月和48个月后，kos（膝关节损伤和骨关节炎结局评分）指数的临床变化和最终PASE的变化，以及（IIIB）纵向评估T2值、影像学表现和形态MR序列（WORMS）诊断的局灶性关节病变与48个月期间疼痛量表、PASE和身体表现变化的关系。该研究将在300名根据WOMAC评分、年龄45-60岁、基线体重指数正常、无疼痛的OAI发病率队列中招募受试者。在4年的时间里，将分析半定量和定量磁共振成像参数与临床表现的关系。我们坚信，我们通过这项研究获得的知识进步将帮助我们更好地理解T2值在OA演变中的作用，并将有助于我们将预防工作集中在疾病的早期阶段。这项研究也可能为生活方式因素提供证据，这些因素可能被修改以预防骨关节炎的发展。

DESCRIPTION (provided by applicant): This study will thoroughly investigate the potential role and significance of cartilage T2 relaxation time as a potential outcome marker for early osteoarthritis. It will focus on asymptomatic (according to WOMAC pain score) subjects of the incidence cohort of the OAI with varying degrees of physical activity, who are at increased risk for osteoarthritis. A number of these subjects will eventually develop osteoarthritis over the course of this 48 months longitudinal study and the proposed data analysis will provide unique information on the evolution of MR based biomarkers in this cohort. The specific aims are (I) to assess prevalence of cartilage, meniscal and ligamentous lesions in subjects from the incidence cohort of the OAI aged 45-60 years without pain using the whole organ magnetic resonance imaging score (WORI\/IS) in relation to physical activity determined by the physical activity scale for the elderly (RASE) and physical performance tests, (II) to measure cartilage T2 of all joint compartments combined and separately and correlate these quantitative measurements with prevalence and grade of focal cartilage, meniscal, ligamentous and bone marrow lesions as well as measurements of physical activity and physical performance, (IIIA) to analyze whether baseline T2 values will predict focal lesion progression diagnosed with H/OR/WS, clinical changes in KOOS (Knee Injury and Osteoarthritis Outcome Score) indices and eventually changes in PASE after 24 and 48 months and (IIIB) to longitudinally assess changes in T2 values, radiographic findings and focal joint lesions diagnosed with morphological MR sequences (WORMS) in relation to changes of pain scales, PASE and physical performance over a period of 48 months. The study will be performed in 300 subjects recruited from the incidence cohort of the OAI with no pain based on WOMAC scores, age 45-60 years and normal body mass index at baseline. Semiquantitative and quantitative MR imaging parameters will be analyzed in relation to clinical findings over a period of 4 years. We strongly believe, that the advances in knowledge that we gain through this study will help us better understand the role of T2 values in OA in relation to the evolution of OA and will help in focusing our preventive efforts on the earliest disease stages. This study may also provide evidence on life style factors that may be modified to prevent the development of osteoarthritis. RELEVANCE (See instructions): The combined analyses of morphological and quantitative MR imaging findings in relation to clinical findings will help us better understand the evolution of osteoarthritis at its earliest stages. Assessing cartilage matrix quality determined with T2 measurements may potentially gain a similar role in predicting risk of osteoarthritis such as bone mineral density currently has in predicting osteoporotic fractures. This longitudinal study performed in patients from the incidence cohort of the OAI will for the first time provide evidence whether cartilage T2 can predict development of OA, study MR findings associated with the evolution of OA and potentially give evidence on how long-term to prevent osteoarthritis and disability.