Early Markers of Alzheimer Disease

阿尔茨海默病的早期标志

• 批准号: 8552327
• 负责人: Alan B Zonderman
• 金额: $ 49.99万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8552327
• 关键词: Age; Aging; Alzheimer' s Disease; Attention; Autopsy; Baltimore; Cognitive; Collaborations; Degenerative Disorder; Dementia; Diagnosis; Disease; Enrollment; Family; Home environment; Impaired cognition; Individual; Language; Learning; Longitudinal Studies; Measures; Memory; Mental Depression; Mission; National Institute on Aging; Neurologic; Participant; Performance; Prospective Studies; Research; Risk Factors; Role; Sampling; Semantic memory; Sorting - Cell Movement; Testing; Time; Visit; aged; base; case control; cognitive function; depressive symptoms; executive function; indexing; mental state; neuropathology; neuropsychological; prospective; psychologic; sex; visual memory

The Baltimore Longitudinal Study of Aging (BLSA) was established in 1958 and is one the oldest prospective studies of aging in the USA and the world. The mission of the BLSA is to learn what happens to people as they get old and how to sort out changes due to aging and from those due to disease or other causes. Most of our analyses examine the trajectories of performance levels over time. However, we have suspected that there is important information in the inconsistencies in performance, and that greater within individual variability might be associated with subsequent cognitive impairment and dementia. In a case-control sample of Baltimore Longitudinal Study of Aging (mean SD age = 69.90 8.92) participants, we matched 135 clinically diagnosed demented participants with 135 non-demented participants based on age at initial testing and sex. Cognitive performance was examined using measures of memory, executive function, attention, language, and global mental status performance from initial assessment to 5 years before cognitive impairment (mean assessments = 3.03). Compared with unimpaired individuals, individuals diagnosed with dementia had greater variability on measures of attention, executive function, language, and semantic memory at least 5 years before the estimated onset of cognitive impairment, which may indicate maladaptive cognitive functioning. The dementia cases, however, had less variability on visual memory than the unimpaired group, which may suggest that these cases had more difficulty learning. These results suggest that performance variability indexed over annual or biennial visits may be useful in identifying early signs of subsequent cognitive impairment.

巴尔的摩老龄化纵向研究(BLSA)成立于1958年，是美国和世界上最古老的前瞻性老龄化研究之一。BLSA的使命是了解人们变老后会发生什么，以及如何区分由于衰老和疾病或其他原因造成的变化。 我们的大多数分析都考察了性能水平随时间变化的轨迹。然而，我们怀疑，在表现上的不一致中有重要的信息，个体内更大的变异性可能与随后的认知障碍和痴呆症有关。在巴尔的摩老年纵向研究(平均SD年龄=69.90 8.92)参与者的病例对照样本中，我们根据初始测试的年龄和性别将135名临床诊断为痴呆的参与者与135名非痴呆参与者进行了配对。使用记忆、执行功能、注意力、语言和整体精神状态表现的测量来检查从最初评估到认知损伤前5年的认知表现(平均评估=3.03)。与正常个体相比，被诊断为痴呆症的个体在至少5年前的注意力、执行功能、语言和语义记忆的测量上有更大的变异性，这可能表明认知功能不良。然而，痴呆症患者在视觉记忆上的变异性比非痴呆组小，这可能表明这些患者在学习上更困难。这些结果表明，在每年或两年一次的访问中编制的表现变异性指数可能有助于识别后续认知障碍的早期迹象。