Manufacturing of Soft Actuator Devices for Intravascular Intervention

血管内介入软执行器装置的制造

• 批准号: 8251758
• 负责人: Robert C McDonald
• 金额: $ 15万
• 依托单位: GINER, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-12 至 2013-03-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8251758
• 关键词: Acute; Affect; Air; Animal Model; Area; Arteriovenous malformation; Biological; Biomimetics; Biosensor; Blood Clot; Blood coagulation; Cardiovascular Diseases; Clinical; Complex; Consult; Development; Devices; Diagnostic; Doctor of Medicine; Doctor of Philosophy; Electrodes; Electrolytes; Electronics; Elements; Encapsulated; Equipment; Excision; Freedom; Goals; Implantable Pump; Intervention; Ischemia; Laboratories; Life Cycle Stages; Liquid substance; Malignant Neoplasms; Massachusetts; Measurement; Mechanics; Medical; Medical Device; Membrane; Methods; Metric; Modeling; Motion; Movement; Muscle; Nafion; Outcome; Performance; Phase; Polymers; Positioning Attribute; Process; Production; Property; Prosthesis; Reporting; Research; Research Design; Residual state; Simulate; Solvents; Stress; Structure; Technology; Testing; Text; Thrombectomy; Time; Transducers; Universities; Work; aqueous; base; biomaterial compatibility; cost; design; electronic structure; experience; flexibility; improved; light weight; manufacturing process; medical schools; minimally invasive; parylene; prevent; professor; programs; prototype; research and development; response; scale up; sensor; tool; voltage

DESCRIPTION (provided by applicant): Electronically Activated Polymer (EAP) structures hold great potential for use in several medical applications, including implantable pumps and actuators, artificial muscles, microtools for intravascular intervention and soft prosthetics. The structures can be incorporated in very low-power electronics, providing precise control of force and movement in constrained and complex geometries. These designs enable the development of new minimally invasive strategies to treat acute cardiovascular disease, arteriovenous malformations (AVM) and cancer. Giner, Inc. will leverage its fabrication and manufacturing methods to substantially improve EAP mechanical performance and manufacturability with reductions in cost. The devices can operate as actuators with rapid, controlled force or as sensors for precise measurement of force and position. Polymer-based electromechanical transducers will be fabricated and demonstrated with improved electrode structures, tolerance to atmospheric exposure and improved flex response for biomimetic sensors and actuators. The research design entails implementation of proprietary manufacturing and processing methods and equipment to prepare EAP structures for a proof-of-concept component for use in a medical tool for thrombectomy in cases of acute ischemia. This project focuses on the development and demonstration of an effective EAP device for intravascular thrombectomy to be tested in animal models in Phase II. PUBLIC HEALTH RELEVANCE: The proposed research will develop manufacturing methods to make Electronically Activated Polymer (EAP) devices enabling the development of a tool for complete endovascular removal of blood clots without residual fragments released downstream or adherent material remaining on the vessel wall, as is often the case with current thrombectomy approaches. The proposed EAP will have increased force and displacement control over commercial devices presently in use. An ultrathin coating prevents biofouling, solvent loss and provides long flex cycle life.

描述（由申请人提供）：电子活化聚合物（EAP）结构在多种医疗应用中具有巨大的潜力，包括植入式泵和致动器、人造肌肉、用于血管内介入的微型工具和软假体。这些结构可以集成到非常低功率的电子设备中，在受限和复杂的几何形状中提供精确的力和运动控制。这些设计使得能够开发新的微创策略来治疗急性心血管疾病、动静脉畸形（AVM）和癌症。Giner公司将利用其制造和制造方法来显著改善EAP机械性能和可制造性，同时降低成本。这些设备可以作为具有快速、受控力的致动器或用于精确测量力和位置的传感器。聚合物基机电传感器将被制造和演示，具有改进的电极结构、对大气暴露的耐受性和改进的仿生传感器和致动器的弯曲响应。研究设计需要实施专有的制造和加工方法和设备，以制备EAP结构，用于在急性缺血情况下用于血栓切除术的医疗工具中使用的概念验证组件。该项目的重点是开发和证明一种有效的EAP装置，用于血管内血栓切除术，并在第二阶段的动物模型中进行测试。 公共卫生相关性：拟议的研究将开发制造电子活化聚合物（EAP）器械的制造方法，从而能够开发一种用于完全血管内清除血栓的工具，而不会像当前血栓切除术方法那样在下游释放残留碎片或在血管壁上残留粘附材料。与目前使用的商业器械相比，拟议的EAP将具有更大的力和位移控制。一个可固化涂层防止生物污垢，溶剂损失，并提供长期的弯曲循环寿命。